Results 51 to 60 of about 923,068 (299)

The myth of 'the myth of Irish neutrality': deconstructing concepts of Irish neutrality using international relations theories [PDF]

, 2006
A number of academics, journalists and political elites claim that Irish neutrality is a 'myth', and many also characterise public support for Irish neutrality as 'confused' and 'nonrational'.
Devine, Karen
core   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Stance phraseology in academic discourse

Ibérica, 2020
El objetivo de este artículo es analizar las colocaciones que emplean los investigadores de Ingeniería Agronómica y Economía para marcar su posición (stance) como autores, y, así, establecer su identidad y autoridad en el discurso académico.
Jihua Dong, Louisa Buckingham
doaj  

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Academic Concept Formation in Bilingual Academic Discourse (the Case of Social Sciences and Humanities)

Вестник Северного (Арктического) федерального университета: Серия «Гуманитарные и социальные науки»
Identifying the influence that the value system and cultural identity of a bilingual have on the use of the language system in academic communication is becoming increasingly important.
Olga S. Zubkova, Ilya G. Nikitichev
doaj   +1 more source

Claiming expertise from betwixt and between: Digital humanities librarians, emotional labor, and genre theory [PDF]

, 2017
Librarians\u27 liminal (intermediate) position within academia situates us to make unique contributions to digital humanities (DH). In this article, we use genre theory, feminist theory, and theories of emotional labor to explore the importance of ...
Logsdon, Alexis, Mars, Amy, Tompkins, Heather   +2 more
core   +2 more sources

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Transcendence over Diversity: black women in the academy [PDF]

, 2006
Universities, like many major public institutions have embraced the notion of ‘diversity’ virtually uncritically- it is seen as a moral ‘good in itself’.
Ahmed S., Ahmed S., Back L., Bhavnani R., Blanden J., Brah A., Brah A., Carter J., Casey K., Castells M., Collins P.H., Collins P.H., Connor H., Equality Challenge Unit (ECU) &, Fraser N., Freire P., Hall S., Hall S., Higher Education Funding Council for England (HEFCE), Hooks B., Hooks B., Housee S., Law I., Lopez I.H., Metcalf H., Mirza H.S., Mirza H.S., Mirza H.S., Mirza H.S., Mirza H.S., Modood T., Mohanty C.T., Morrison T., National Audit Office (NAO), Office Cabinet, Puwar N., Razack S., Reay D., Schneider-Ross, Simmonds F., Society Fawcett, Spivak G., Williams P.J., Women &, Young R.J.C.   +44 more
core   +2 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source