Results 121 to 130 of about 1,222 (132)

Impact of ST-246 on ACAM2000™ smallpox vaccine reactogenicity, immunogenicity, and protective efficacy in immunodeficient mice [PDF]

Vaccine, 2010
Although a highly effective vaccine against smallpox, vaccinia virus (VV) is not without adverse events, some of which can be life-threatening, particularly in immunocompromised individuals. We have recently demonstrated that the immunogenicity and protective efficacy of Dryvax(®) in immunocompetent mice is preserved even when co-administered with ST ...
Douglas W Grosenbach, Dennis E Hruby, Kevin F Jones   +2 more
exaly   +3 more sources

Ischemic cardiac events and other adverse events following ACAM2000 smallpox vaccine in the Vaccine Adverse Event Reporting System [PDF]

Vaccine, 2014
The Vaccine Adverse Event Reporting System (VAERS) is a passive reporting system, used for monitoring the safety of all US licensed vaccines. In March 2008, ACAM2000(®) replaced Dryvax(®) as the only licensed smallpox vaccine and is administered to all persons entering military service and certain civilian researchers.
Michael M McNeil
exaly   +3 more sources

Adverse Events Following Smallpox Vaccination With ACAM2000 in a Military Population [PDF]

Archives of Dermatology, 2010
Generalized vaccinia and benign exanthems are 2 adverse events that have been associated with the smallpox vaccination. Accurate incidence and prevalence rates of each are not readily available, but these events are thought to be uncommon. To our knowledge, this is the first case series to provide clinical as well as pathologic descriptions of multiple
Thomas M, Beachkofsky, Scott C, Carrizales, Jeffrey J, Bidinger, David E, Hrncir, Darren E, Whittemore, Chad M, Hivnor   +5 more
exaly   +3 more sources

Cutaneous reactions associated with ACAM2000 smallpox vaccination in a deploying U.S. Army unit. [PDF]

Military Medicine, 2015
Since 2003, the U.S. Army has vaccinated deploying troops for smallpox. In 2008, the U.S. military transitioned to the second-generation vaccine ACAM2000. Cutaneous adverse events associated with this vaccine are rarely characterized. We review the medical literature on cutaneous adverse events with ACAM2000 and describe four new cases that occurred in
Randall, Freeman, Brittany, Lenz
exaly   +3 more sources

Treatment with the smallpox antiviral tecovirimat (ST-246) alone or in combination with ACAM2000 vaccination is effective as a postsymptomatic therapy for monkeypox virus infection. [PDF]

Antimicrobial Agents and Chemotherapy, 2015
ABSTRACT The therapeutic efficacies of smallpox vaccine ACAM2000 and antiviral tecovirimat given alone or in combination starting on day 3 postinfection were compared in a cynomolgus macaque model of lethal monkeypox virus infection. Postexposure administration of ACAM2000 alone did not provide any protection against severe monkeypox disease ...
Douglas W Grosenbach, Dennis E Hruby, Kady M Honeychurch   +2 more
exaly   +3 more sources

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Smallpox vaccine, ACAM2000: Sites and duration of viral shedding and effect of povidone iodine on scarification site shedding and immune response

Vaccine, 2015
The U.S. Department of Defense vaccinates personnel deployed to high-risk areas with the vaccinia virus (VACV)-based smallpox vaccine. Autoinoculations and secondary and tertiary transmissions due to VACV shedding from the vaccination site continue to occur despite education of vaccinees on the risks of such infections.
Mark G Kortepeter, Sung-Han Kim, Phillip Pittman   +2 more
exaly   +3 more sources

Comparison of the immunogenicity and protective efficacy of ACAM2000, MVA, and vectored subunit vaccines for Mpox in rhesus macaques

Science Translational Medicine
The 2022–2023 mpox outbreak triggered vaccination efforts using smallpox vaccines that were approved for mpox, including modified vaccinia Ankara (MVA; JYNNEOS), which is a safer alternative to live replicating vaccinia virus (ACAM2000). Here, we compare the immunogenicity and protective efficacy of JYNNEOS by the subcutaneous or intradermal routes ...
Dan H. Barouch, Michael S Seaman, Catherine Jacob-Dolan   +2 more
exaly   +3 more sources

A proteome-wide comparison of human antibody responses to the standard polyclonal vaccine for smallpox prevention and the monoclonal replacement ACAM2000 (P4321)

The Journal of Immunology, 2013
Abstract Smallpox was eradicated in the 1980s due to the success of vaccines such as Dryvax (Wyeth Laboratories, Inc., U.S.). However, production of an improved live-virus vaccine was needed due to the limited amount of Dryvax doses available, as well as manufacturing concerns over the sterility and the clonal heterogeneity of the ...
Robert Ulrich, Christine Pugh, Sarah Keasey, Phillip Pittman   +3 more
openaire   +1 more source

Genomic differences of Vaccinia virus clones from Dryvax smallpox vaccine: The Dryvax-like ACAM2000 and the mouse neurovirulent Clone-3

Vaccine, 2007
Conventional vaccines used for smallpox eradication were often denoted one or another strain of Vaccinia virus (VACV), even though seed virus was sub-cultured multifariously, which rendered the virion population genetically heterogeneous. ACAM2000 cell culture vaccine, recently licensed in the U.S., consists of a biologically vaccine-like VACV ...
John D, Osborne, Melissa, Da Silva, A Michael, Frace, Scott A, Sammons, Melissa, Olsen-Rasmussen, Chris, Upton, R Mark L, Buller, Nanhai, Chen, Zehua, Feng, Rachel L, Roper, Jonathan, Liu, Svetlana, Pougatcheva, Weiping, Chen, Robert M, Wohlhueter, Joseph J, Esposito   +14 more
openaire   +2 more sources

JYNNEOS VS. ACAM2000: A CRITICAL REVIEW OF THE SAFETY, EFFICACY AND REAL-WORLD EFFECTIVENESS OF MONKEYPOX VACCINES

The current global outbreak of monkeypox, a zoonotic virus that shares similarities with smallpox (such as the characteristic rash and mode of transmission, though monkeypox generally has a lower fatality rate and less severe symptoms), has raised significant interest. Vaccination is seen as a critical preventive strategy, with the emergence of JYNNEOS
Benish Javed, Ramna Zia, Muhammad Imran
openaire   +1 more source