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Journal of Education, Health and Sport, 2022 Introduction and purpose: This review aims to analyze the current information about monkeypox and the virus which causes the disease. Material and method: This review was based on articles collected in PubMed and published in the years 2012-2022
Aleksandra Amalia Kuchnicka +8 more
doaj +3 more sources
Viruses, 2022 Monkeypox disease (MPX) is currently considered a global threat after COVID-19. European Medicines Agency (EMA) approved Tecovirimat in capsule dosage form (200 mg) as the first treatment for MPX in January 2022.
Mazen Almehmadi +2 more
exaly +3 more sources
Monkeypox - new epidemiological threat? Review of the current literature [PDF]
Journal of Education, Health and Sport, 2023 The mokeypox is zoonotic disease caused by an orthopoxvirus, which was first isolated and identified in 1959 among captive monkeys transported to Copenhagen, Denmark from Africa for research purposes.
Dominika Jarosz +4 more
doaj +3 more sources
Effect of tecovirimat on healing time and viral clearance by emulation of a target trial in patients hospitalized for mpox [PDF]
Journal of Medical Virology, 2023 Tecovirimat is a treatment option for severe mpox, although randomized clinical trials are ongoing. The aim of the study is to assess the effect of tecovirimat on healing time and the extent of viral clearance by target trial emulation using ...
Valentina Mazzotta +2 more
exaly +6 more sources
Structural and dynamic insights into F13L variations in monkeypox virus and their impact on tecovirimat resistance [PDF]
Virology JournalThe recent global outbreak of Monkeypox virus since 2022, particularly outside Africa, has underscored its significant threat to public health. Genomic surveillance from multiple countries has revealed diverse genetic variations among circulating ...
Yao Wang +3 more
doaj +2 more sources
Antiviral Drugs for Treatment of Human Monkeypox: A Systematic Review/Meta-analysis [PDF]
Microbes, Infection and ChemotherapyBackground. On 23 July 2022, the World Health Organization declared a Public Health Emergency of International Concern. Monkeypox is a zoonotic viral disease caused by the monkeypox virus that is transmitted from animals to humans or from human to human.
Ahmed Mohamed Abdelghany +2 more
doaj +3 more sources
Oral Tecovirimat for the Treatment of Smallpox [PDF]
New England Journal of Medicine, 2018 Smallpox was declared eradicated in 1980, but variola virus (VARV), which causes smallpox, still exists. There is no known effective treatment for smallpox; therefore, tecovirimat is being developed as an oral smallpox therapy. Because clinical trials in a context of natural disease are not possible, an alternative developmental path to evaluate ...
Anne M Laudisoit
exaly +8 more sources
HeliyonThis article delineates the systematic identification, synthesis, and impurity control methods used during the manufacturing process development of tecovirimat, an antiviral drug that treats monkeypox.
Emmanuel Mintah Bonku +8 more
doaj +3 more sources
Tecovirimat: A journey from discovery to mechanistic insights in poxvirus inhibition. [PDF]
PLoS PathogensTecovirimat (ST-246 or TPOXX) is an antiviral agent developed as part of a U.S. biodefense initiative aimed at addressing Orthopoxvirus infections, including smallpox and mpox.
Xue Li, Zhengyang Pan, Leiliang Zhang
doaj +2 more sources
Evaluating the advancements and efficacies in pharmacological Mpox treatments: a comprehensive review [PDF]
Frontiers in PharmacologyMonkeypox, now known as Mpox, has reemerged as a serious public health threat due to an increasing number of outbreaks outside its primary endemic regions. Although virologically similar to smallpox, smallpox therapy is not specifically approved for Mpox.
Shuaibu Abdullahi Hudu +6 more
doaj +2 more sources