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A Global Health Alert on the Re‐Emergence of Mpox a Viral Zoonotic Illness Its Prevention and Management: A Narrative Review [PDF]

Health Science Reports
Background and Aims Monkeypox virus (MPXV) is gaining attention in the global health community due to its potential for human transmission and similarities to the well‐known smallpox virus.
Muslim Bin Aqeel, Asif Hanif, Shahzad Ahmad, Fatima Iftikhar Shah, Benish Javed, Shazia Iqbal   +5 more
doaj   +3 more sources

Preclinical activity of brincidofovir in peripheral T-cell and NK/T-cell lymphoma [PDF]

BMC Medicine
Background Brincidofovir (BCV) is a novel nucleoside phosphonate analogue with unique dual antiviral and anti-tumor properties. Methods The activity of BCV was evaluated in 44 cell-line models, including T/NK-cell non-Hodgkin lymphoma (T/NK-NHL, n = 25 ...
Jason Yongsheng Chan, Elizabeth Chun Yong Lee, Kelila Xin Ye Chai, Boon Yee Lim, Zhimei Li, Jing Yi Lee, Bavani Kannan, Hui Yi Tay, Tun Kiat Ko, Jessica Sook-Ting Kok, Kah Suan Lim, Nur Ayuni Binte Muhammad Taib, Dachuan Huang, Jing Quan Lim, Masatoshi Hazama, Koji Fukushima, Bin Tean Teh, Soon Thye Lim, Choon Kiat Ong   +18 more
doaj   +4 more sources

Assessment of three antiviral compounds against Borealpox virus infection in a mouse model [PDF]

Emerging Microbes and Infections
Borealpox virus (BRPV) is a zoonotic orthopoxvirus which was first documented in Alaska in 2015. Although most human infections are mild, a recent fatal case in an immunocompromised individual highlights the importance of studying this emerging pathogen.
Jérémie Prévost, Nikesh Tailor, Angela Sloan, Kathleen Fulton, Sarah J. Medina, Jonathan Audet, Geoff Soule, David Safronetz   +7 more
doaj   +2 more sources

Seminal fluid enhances monkeypox virus infection via amyloidogenic fibrils [PDF]

Emerging Microbes and Infections
Mpox is a re-emerging zoonosis caused by monkeypox virus (MPXV), with recent outbreaks driven by sexual transmission. How semen contributes to MPXV infection, however, remains unclear.
Emma Torbica, Matthias Denkewitz, Tamara Quick, Nadja Zöller, Katja Steinhorst, Stefan Kippenberger, Florian Rothweiler, Jindrich Cinatl, Pia Veratti, Florian Full, Undraga Schagdarsurengin, Sandra Ciesek, Jan Münch, Janis A. Müller, Denisa Bojkova   +14 more
doaj   +2 more sources

Concurrent Mpox and HSV-1 Proctitis in a Young Male With AIDS: A Case Report of Treatment Failure [PDF]

Case Reports in Infectious Diseases
Managing the mpox in patients with advanced HIV infection and coinfections poses significant challenges. This report discusses a young male with advanced HIV (CD4 count 28) and severe concurrent mpox and HSV-1 proctitis.
Mikhail Sukhoroslov, Fouad Kaddour-Hocine, Muhammad Hammad Ashraf, Navya Mandalapu, Shivani Bansal, Matthew Peachey   +5 more
doaj   +2 more sources

On topological co-index polynomials for predictive modeling of the physicochemical properties of antiviral drugs [PDF]

Scientific Reports
This study investigates the potential of topological co-indices and their polynomials as computational tools for predicting the physicochemical properties of antiviral compounds targeting the Ebola virus.
Summeira Meharban, Asad Ullah, Shahid Zaman, Assmaa Abd-Elmonem, Parvez Ali, Neissrien Alhubieshi, Melaku Berhe Belay   +6 more
doaj   +2 more sources

Broad-spectrum antiviral brincidofovir inhibits Epstein-Barr virus and related gammaherpesvirus in human and nonhuman primate cells [PDF]

The Journal of Clinical Investigation
Epstein-Barr virus (EBV) is of growing interest for its potential role in neurodegenerative diseases such as multiple sclerosis (MS) and its possible utility as a therapeutic target in herpesvirus-associated chronic diseases. The effects of brincidofovir
Abaigeal Donaldson, Madeleine R. Druker, Maria Chiara Monaco, Emily H. Stack, Paige Zimmerman, Amanda Lee, Izabela Bialuk, William Frazier, Irene Cortese, Heather Narver, Masatoshi Hazama, Fuminori Yoshida, Xiaofan Li, Laurie T. Krug, Stacey L. Piotrowski, Steven Jacobson   +15 more
doaj   +2 more sources

Disseminated Mpox infection, a rare case of an immunocompromised patient treated with tecovirimat and brincidofovir [PDF]

JAAD Case Reports
Paytra A. Klein, MBA, Rose Parisi, MD, Ananthakrishnan Ramani, MD   +2 more
doaj   +2 more sources

Battle won, war ongoing: A call for mpox vaccination in high-risk dermatologic cases [PDF]

JAAD Case Reports
Atika Malik, MD, Monique Kumar, MD, Tien-Anh N. Tran, MD, Timmy Do, PharmD, BCPS, BCIDP, Lindsay Lim, MD, DTMH   +4 more
doaj   +2 more sources

Brincidofovir is a robust replication inhibitor against African swine fever virus in vivo and in vitro

Emerging Microbes and Infections, 2023
African swine fever virus (ASFV) infection is a major public and socioeconomic concern that has a serious impact on the global swine industry. Unfortunately, there are currently no commercially available vaccines or antiviral agents that are both safe ...
Shibang Guo, Yibo Zhang, Zhankui Liu, Daozhong Wang, Hui Liu, Liang Li, Qichao Chen, Dan Yang, Qingyun Liu, Huihui Guo, Shuang Mou, Huanchun Chen, Xiangru Wang   +12 more
doaj   +1 more source