Experimental Treatment of Ebola Virus Disease with Brincidofovir. [PDF]
PLoS ONE, 2016 BackgroundThe nucleotide analogue brincidofovir was developed to prevent and treat infections caused by double-stranded DNA viruses. Based on in vitro data suggesting an antiviral effect against Ebola virus, brincidofovir was included in the World Health
Jake Dunning +15 more
doaj +14 more sources
Assessment of three antiviral compounds against Borealpox virus infection in a mouse model [PDF]
Emerging Microbes and InfectionsBorealpox virus (BRPV) is a zoonotic orthopoxvirus which was first documented in Alaska in 2015. Although most human infections are mild, a recent fatal case in an immunocompromised individual highlights the importance of studying this emerging pathogen.
Jérémie Prévost +7 more
doaj +2 more sources
Antiviral Drugs for Treatment of Human Monkeypox: A Systematic Review/Meta-analysis [PDF]
Microbes, Infection and ChemotherapyBackground. On 23 July 2022, the World Health Organization declared a Public Health Emergency of International Concern. Monkeypox is a zoonotic viral disease caused by the monkeypox virus that is transmitted from animals to humans or from human to human.
Ahmed Mohamed Abdelghany +2 more
doaj +3 more sources
Successful Treatment of Adenovirus Infection with Brincidofovir in an Immunocompromised Patient after Hematological Stem Cell Transplantation [PDF]
Case Reports in Infectious Diseases, 2020 Immunocompromised patients, including hematopoietic stem cell transplantation (HSCT), HIV, and malnourished patients, are at increased risk for viral infections with high incidences of morbidity and mortality.
T. Van Genechten +3 more
doaj +3 more sources
Biomedicines, 2023 The monkeypox disease (MPX) outbreak of 2022 has been reported in more than one hundred countries and is becoming a global concern. Unfortunately, only a few treatments, such as tecovirimat (TCV), are available against MPX.
Mohd Imran +2 more
exaly +3 more sources
Preclinical activity of brincidofovir in peripheral T-cell and NK/T-cell lymphoma [PDF]
BMC MedicineBackground Brincidofovir (BCV) is a novel nucleoside phosphonate analogue with unique dual antiviral and anti-tumor properties. Methods The activity of BCV was evaluated in 44 cell-line models, including T/NK-cell non-Hodgkin lymphoma (T/NK-NHL, n = 25 ...
Jason Yongsheng Chan +18 more
doaj +2 more sources
Disseminated Adenovirus Infection After Combined Liver-Kidney Transplantation [PDF]
Frontiers in Cellular and Infection Microbiology, 2018 Human adenovirus (HAdV) infections are well-described after hematopoietic stem cell transplantation but less well understood in solid organ transplantation (SOT).
Marion Hemmersbach-Miller +6 more
doaj +3 more sources
Concurrent Mpox and HSV-1 Proctitis in a Young Male With AIDS: A Case Report of Treatment Failure [PDF]
Case Reports in Infectious DiseasesManaging the mpox in patients with advanced HIV infection and coinfections poses significant challenges. This report discusses a young male with advanced HIV (CD4 count 28) and severe concurrent mpox and HSV-1 proctitis.
Mikhail Sukhoroslov +5 more
doaj +2 more sources
On topological co-index polynomials for predictive modeling of the physicochemical properties of antiviral drugs [PDF]
Scientific ReportsThis study investigates the potential of topological co-indices and their polynomials as computational tools for predicting the physicochemical properties of antiviral compounds targeting the Ebola virus.
Summeira Meharban +6 more
doaj +2 more sources
Lactoferrin blocks orthopoxvirus entry via heparan sulphate and regulates host antiviral pathways [PDF]
Emerging Microbes and InfectionsCurrent antiviral therapies for orthopoxviruses face critical challenges, including limited efficacy and significant toxicity, which impede outbreak containment and clinical management.
Lili Tian +15 more
doaj +2 more sources