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A Global Health Alert on the Re‐Emergence of Mpox a Viral Zoonotic Illness Its Prevention and Management: A Narrative Review [PDF]
Health Science ReportsBackground and Aims Monkeypox virus (MPXV) is gaining attention in the global health community due to its potential for human transmission and similarities to the well‐known smallpox virus.
Muslim Bin Aqeel +5 more
doaj +3 more sources
The Role of Brincidofovir in Preparation for a Potential Smallpox Outbreak [PDF]
Viruses, 2017 Smallpox (variola) virus is considered a Category A bioterrorism agent due to its ability to spread rapidly and the high morbidity and mortality rates associated with infection. Current recommendations recognize the importance of oral antivirals and call
Scott Parker +2 more
exaly +5 more sources
International Journal of Infectious DiseasesAn mpox outbreak was declared in July 2022 by the world health organization (WHO). It causes a mild self-limiting disease however; in immunosuppressed hosts, it tends to cause severe disseminated infection.
Ali M Shendi, Reem Alameer, Alaa Alali
exaly +5 more sources
Experimental Treatment of Ebola Virus Disease with Brincidofovir. [PDF]
PLoS ONE, 2016 BackgroundThe nucleotide analogue brincidofovir was developed to prevent and treat infections caused by double-stranded DNA viruses. Based on in vitro data suggesting an antiviral effect against Ebola virus, brincidofovir was included in the World Health
Jake Dunning +15 more
doaj +5 more sources
Emerging Microbes and Infections, 2023 African swine fever virus (ASFV) infection is a major public and socioeconomic concern that has a serious impact on the global swine industry. Unfortunately, there are currently no commercially available vaccines or antiviral agents that are both safe ...
Qichao Chen
exaly +3 more sources
Assessment of three antiviral compounds against Borealpox virus infection in a mouse model [PDF]
Emerging Microbes and InfectionsBorealpox virus (BRPV) is a zoonotic orthopoxvirus which was first documented in Alaska in 2015. Although most human infections are mild, a recent fatal case in an immunocompromised individual highlights the importance of studying this emerging pathogen.
Jérémie Prévost +7 more
doaj +2 more sources
Biomedicines, 2023 The monkeypox disease (MPX) outbreak of 2022 has been reported in more than one hundred countries and is becoming a global concern. Unfortunately, only a few treatments, such as tecovirimat (TCV), are available against MPX.
, Mandeep Kumar Arora, Mehnaz Kamal
exaly +3 more sources
Antiviral activity of brincidofovir on parvovirus B19 [PDF]
Antiviral Research, 2019 Parvovirus B19 (B19V), a single-stranded DNA virus in the family Parvoviridae, is a human pathogenic virus responsible for a wide range of clinical manifestations. Currently there is no approved antiviral therapy for parvovirus infection. The acyclic nucleoside phosphonate cidofovir (CDV) has been demonstrated to inhibit replication of B19V in vitro ...
Francesca Bonvicini +2 more
exaly +5 more sources
Preclinical activity of brincidofovir in peripheral T-cell and NK/T-cell lymphoma [PDF]
BMC MedicineBackground Brincidofovir (BCV) is a novel nucleoside phosphonate analogue with unique dual antiviral and anti-tumor properties. Methods The activity of BCV was evaluated in 44 cell-line models, including T/NK-cell non-Hodgkin lymphoma (T/NK-NHL, n = 25 ...
Jason Yongsheng Chan +18 more
doaj +2 more sources
Brincidofovir inhibits polyomavirus infection in vivo
mBioPolyomaviruses are species-specific DNA viruses that can cause disease in immunocompromised individuals. Despite their role as the causative agents for several diseases, there are no currently approved antivirals for treating polyomavirus infection ...
Arrienne B. Butic +6 more
doaj +3 more sources