Results 41 to 50 of about 2,652 (202)

In Vitro Efficacy of Brincidofovir against Variola Virus [PDF]

Antimicrobial Agents and Chemotherapy, 2014
ABSTRACT Brincidofovir (CMX001), a lipid conjugate of the acyclic nucleotide phosphonate cidofovir, is under development for smallpox treatment using “the Animal Rule,” established by the FDA in 2002. Brincidofovir reduces mortality caused by orthopoxvirus infection in animal models.
Victoria A, Olson, Scott K, Smith, Scott, Foster, Yu, Li, E Randall, Lanier, Irina, Gates, Lawrence C, Trost, Inger K, Damon   +7 more
openaire   +2 more sources

Clinical Features Present, Past & Future Prospective of Monkey Pox: A Orthopoxvirus [PDF]

, 2023
Some issues regarding the potential spread of monkeypox have arisen just as the international world is beginning to recover from the initial alarm that was caused by the probable spread of coronavirus disease 2019 (COVID-19).
Kumar, Roshan, Mittal, Chavi, Rana, Sarthak, Rana, Vinod, Rawat, Naveen, Shukla, Siddhartha, Sood, Prachi   +6 more
core   +2 more sources

Monkeypox – An emerging pandemic

IDCases, 2022
Monkeypox–a zoonotic disease caused by the monkeypox virus, an orthopoxviruses family member. Recently monkeypox cases are increasing at an alarming rate in the US and worldwide.
Kunal M. Ajmera, Lokesh Goyal, Trupti Pandit, Ramesh Pandit   +3 more
doaj   +1 more source

Autologous adoptive T-cell therapy for recurrent or drug-resistant cytomegalovirus complications in solid organ transplant patients: a single-arm open-label phase I clinical trial [PDF]

, 2018
BACKGROUND: Opportunistic infections including cytomegalovirus (CMV) are a major cause of morbidity and mortality in solid organ transplant (SOT) recipients.
Beagley, Leone, Campbell, Scott, Chambers, Daniel, Crooks, Pauline, Francis, Ross, Holmes, Mark, Holmes-Liew, Chien-Li, Hopkins, Peter, Khanna, Rajiv, McKenzie, Scott, Neller, Michelle A., Rehan, Sweera, Smith, Corey, Solomon, Matthew   +13 more
core   +1 more source

Clinical Features, Antiviral Treatment, and Patient Outcomes:A Systematic Review and Comparative Analysis of the Previous and the 2022 Mpox Outbreaks [PDF]

, 2023
Background:This study aims to comparatively analyze clinical features, treatment, and patient outcomes between the previous and the 2022 mpox (monkeypox) outbreaks.
Avan, Amine, Ayada, Ibrahim, de Vries, Annemarie C., Li, Jiajing, Li, Pengfei, Pan, Qiuwei, Peppelenbosch, Maikel P., Zheng, Qinyue   +7 more
core   +2 more sources

The race for Ebola drugs: pharmaceuticals, security and global health governance [PDF]

, 2016
The international Ebola response mirrors two broader trends in global health governance: (1) the framing of infectious disease outbreaks as a security threat; and (2) a tendency to respond by providing medicines and vaccines.
Anne Roemer-Mahler, Brower Jennifer, Burton Thomas M., Buzan Barry, Calhoun Craig, Clarke Adele, Collier Stephen J., Conrad Peter, Cooper Melinda, Elbe Stefan, Elbe Stefan, Enemark Christian, EU, Fearnley Lyle, Fidler David, Goldacre Ben, Healy David, Hirschler Ben, Hirschler Ben, Institute of Medicine, Kamradt-Scott Adam, Kieny Marie-Paule, Klein Betsy, Koch Erin, Lakoff Andrew, McInnes Colin, Moran Nuala, Nunes Joao, Paul Steven M., Petryna A., Rose Dale, Rushton Simon, Stefan Elbe, Stein Sam, Stroud Clare, US Department of Health and Human Services, US Department of Health and Human Services, US Food and Drug Administration, Weir Lorna, Weir Lorna, Wellcome Trust, and CIDRAP, WHO, Wintour Patrick   +42 more
core   +1 more source

Brincidofovir (CMX001) Inhibits BK Polyomavirus Replication in Primary Human Urothelial Cells [PDF]

Antimicrobial Agents and Chemotherapy, 2015
ABSTRACTBK polyomavirus (BKPyV)-associated hemorrhagic cystitis (PyVHC) complicates 5 to 15% of allogeneic hematopoietic stem cell transplantations. Targeted antivirals are still unavailable. Brincidofovir (BCV; previously CMX001) has shown inhibitory activity against diverse viruses, including BKPyV in a primary human renal tubule cell culture model ...
Garth D. Tylden, Hans H. Hirsch, Christine Hanssen Rinaldo   +2 more
openaire   +3 more sources

Is photodynamic therapy with curcumin suitable for combating monkeypox?

Infectious Diseases and Herbal Medicine, 2023
Monkeypox (MPX) is a zoonotic viral infection caused by the Monkeypox Virus (MPXV), which may spread person-to-person directly. It is currently being treated with previously intended drugs for smallpox or other diseases caused by the orthopoxvirus, such
Siu Kan Law
doaj   +1 more source

Rapid Virologic Response to Brincidofovir in Children with Disseminated Adenovirus Infection

Infection & Chemotherapy, 2021
Disseminated adenovirus infections (d-ADV) after hematopoietic cell transplant (HCT) are often fatal with limited treatment options. Brincidofovir (BCV) a lipid ester of cidofovir is developed for this indication. We report four pediatric HCT recipients with d-ADV treated successfully with BCV.
Shuk Ying Chan, Susan E. Prockop, Farid Boulad, Genovefa A. Papanicolaou, Yeon Joo Lee   +4 more
openaire   +2 more sources

Human monkeypox: a comparison of the characteristics of the new epidemic to the endemic disease

BMC Infectious Diseases, 2022
In May 2022, a new global outbreak of mpox (formerly, human monkeypox) emerged that was declared a public health emergency of international concern by the World Health Organization on July 23, 2022.
Sharon Sukhdeo, Sharmistha Mishra, Sharon Walmsley   +2 more
doaj   +1 more source