Results 11 to 20 of about 1,885 (156)

The Role of Brincidofovir in Preparation for a Potential Smallpox Outbreak [PDF]

Viruses, 2017
Smallpox (variola) virus is considered a Category A bioterrorism agent due to its ability to spread rapidly and the high morbidity and mortality rates associated with infection. Current recommendations recognize the importance of oral antivirals and call
Scott A. Foster, Scott Parker, Randall Lanier   +2 more
doaj   +5 more sources

Experimental Treatment of Ebola Virus Disease with Brincidofovir. [PDF]

PLoS ONE, 2016
BackgroundThe nucleotide analogue brincidofovir was developed to prevent and treat infections caused by double-stranded DNA viruses. Based on in vitro data suggesting an antiviral effect against Ebola virus, brincidofovir was included in the World Health
Jake Dunning, Stephen B Kennedy, Annick Antierens, John Whitehead, Iza Ciglenecki, Gail Carson, Rupa Kanapathipillai, Lyndsey Castle, Rebecca Howell-Jones, Raul Pardinaz-Solis, Jennifer Grove, Janet Scott, Trudie Lang, Piero Olliaro, Peter W Horby, RAPIDE-BCV trial team   +15 more
doaj   +5 more sources

Oral Brincidofovir Therapy for Monkeypox Outbreak: A Focused Review on the Therapeutic Potential, Clinical Studies, Patent Literature, and Prospects

Biomedicines, 2023
The monkeypox disease (MPX) outbreak of 2022 has been reported in more than one hundred countries and is becoming a global concern. Unfortunately, only a few treatments, such as tecovirimat (TCV), are available against MPX.
Mohd. Imran, Mohammed Kanan Alshammari, Mandeep Kumar Arora, Amit Kumar Dubey, Sabya Sachi Das, Mehnaz Kamal, Abdulaziz Saad Abdulrahman Alqahtani, Mohammed Ahmed Yahya Sahloly, Ahmed Hammad Alshammari, Hessah Mohammed Alhomam, Aeshah Mousa Mahzari, Abida, Ali A. Rabaan, Tafadzwa Dzinamarira   +13 more
doaj   +3 more sources

Antiviral activity of brincidofovir on parvovirus B19 [PDF]

Antiviral Research, 2019
Parvovirus B19 (B19V), a single-stranded DNA virus in the family Parvoviridae, is a human pathogenic virus responsible for a wide range of clinical manifestations. Currently there is no approved antiviral therapy for parvovirus infection. The acyclic nucleoside phosphonate cidofovir (CDV) has been demonstrated to inhibit replication of B19V in vitro ...
Bua, Gloria, Conti, Ilaria, Manaresi, Elisabetta, Sethna, Phiroze, Foster, Scott, Bonvicini, Francesca, Gallinella, Giorgio   +6 more
openaire   +6 more sources

Brincidofovir inhibits polyomavirus infection in vivo

mBio
Polyomaviruses are species-specific DNA viruses that can cause disease in immunocompromised individuals. Despite their role as the causative agents for several diseases, there are no currently approved antivirals for treating polyomavirus infection ...
Arrienne B. Butic, Zoe E. Katz, Ge Jin, Koji Fukushima, Masatoshi Hazama, Aron E. Lukacher, Matthew D. Lauver   +6 more
doaj   +3 more sources

Brincidofovir in the Era of Mpox

Expert Review of Anti-infective Therapy
Mpox (formerly monkeypox), a systemic infection caused by the mpox virus (MPXV), has become a global problem of increasing concern. There are currently no antiviral treatments that have been shown to be safe and effective for the treatment of mpox.Brincidofovir is a lipid-modified acyclic nucleotide with in vitro and in vivo activity against multiple ...
James, McCarty, David, Cassie, Shantha, Kodihalli, Efe, Aigbedo, Jing, Tian, Kevin, Yeo, Vanja, Komlenovic, Lovelyn, Charles, Bojan, Drobic, Bob, Warnock   +9 more
openaire   +4 more sources

The successful treatment of mpox with brincidofovir in renal transplant recipients—a report of 2 cases

International Journal of Infectious Diseases
An mpox outbreak was declared in July 2022 by the world health organization (WHO). It causes a mild self-limiting disease however; in immunosuppressed hosts, it tends to cause severe disseminated infection.
Reem M. Alameer, Amani Yamani, Abdulrahman Al-Saud, Sultan Alsobayeg, Bayan Alamro, Alaa Alali, Ehab Hammad, Ali M. Shendi, Reem S. Almaghrabi   +8 more
doaj   +3 more sources

Glucocorticoids Do Not Enhance BK Polyomavirus Replication in Human Renal Proximal Tubular Epithelial Cells In Vitro. [PDF]

Clin Transl Sci
ABSTRACT BK polyomavirus (BKPyV) infection may lead to BKPyV‐associated nephropathy (BKPyVAN) and subsequent graft loss in kidney transplant recipients. Experimental studies have suggested that glucocorticoids (GCs) may enhance BKPyV replication through a steroid‐responsive element within the viral genome.
Moest WT, Lalai RA, Prins J, de Vries APJ, Wessels E, van Kooten C, Feltkamp MCW, Rotmans JI.   +7 more
europepmc   +2 more sources

Brincidofovir Effectively Inhibits Proliferation of Pseudorabies Virus by Disrupting Viral Replication

Viruses
Pseudorabies is an acute and febrile infectious disease caused by pseudorabies virus (PRV), a member of the family Herpesviridae. Currently, PRV is predominantly endemoepidemic and has caused significant economic losses among domestic pigs. Other animals
Huihui Guo, Qingyun Liu, Dan Yang, Hao Zhang, Yan Kuang, Yafei Li, Huanchun Chen, Xiangru Wang   +7 more
doaj   +3 more sources

Novel derivatives of brincidofovir and (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine inhibit orthopoxviruses and human adenoviruses more potently than brincidofovir

Signal Transduction and Targeted Therapy
Brincidofovir (BCV) and tecovirimat are the only two chemical drugs that have been approved to treat smallpox and can be requested for monkeypox (Mpox) treatment through a single-patient Emergency Investigational New Drug (EIND) application ...
Yifan Zhang, Yanmin Wan, Cuiyuan Guo, Zhaoqin Zhu, Chao Qiu, Jiasheng Lu, Yanan Zhou, Jiaojiao Zheng, Fahui Dai, Xiaoyang Cheng, Kunlu Deng, Wanhai Wang, Youchun Wang, Wenhong Zhang   +13 more
doaj   +3 more sources