Results 11 to 20 of about 2,652 (202)

Novel derivatives of brincidofovir and (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine inhibit orthopoxviruses and human adenoviruses more potently than brincidofovir

Signal Transduction and Targeted Therapy
Brincidofovir (BCV) and tecovirimat are the only two chemical drugs that have been approved to treat smallpox and can be requested for monkeypox (Mpox) treatment through a single-patient Emergency Investigational New Drug (EIND) application ...
Yanmin Wan, Zhaoqin Zhu, Chao Qiu
exaly   +4 more sources

The Role of Brincidofovir in Preparation for a Potential Smallpox Outbreak [PDF]

Viruses, 2017
Smallpox (variola) virus is considered a Category A bioterrorism agent due to its ability to spread rapidly and the high morbidity and mortality rates associated with infection. Current recommendations recognize the importance of oral antivirals and call
Scott A. Foster, Scott Parker, Randall Lanier   +2 more
doaj   +3 more sources

Brincidofovir inhibits polyomavirus infection in vivo

mBio
Polyomaviruses are species-specific DNA viruses that can cause disease in immunocompromised individuals. Despite their role as the causative agents for several diseases, there are no currently approved antivirals for treating polyomavirus infection ...
Arrienne B. Butic, Zoe E. Katz, Ge Jin, Koji Fukushima, Masatoshi Hazama, Aron E. Lukacher, Matthew D. Lauver   +6 more
doaj   +3 more sources

Mpox (Monkeypox): A Comprehensive Review of Etiology, Epidemiology, Transmission, Clinical Presentation, Diagnosis, Treatment, and Prevention [PDF]

Quality in Sport
Introduction: The objective of this review is to provide a comprehensive overview of the current state of knowledge about mpox (monkeypox), its etiology, epidemiology, transmission, clinical features, diagnosis, treatment, and prevention.
Urszula Mazur, Paulina Ogonowska, Julia Waszak, Grzegorz Adaśko, Michał Świda, Jakub Bazarewicz, Anna Michalska, Marcin Siwik, Cezary Kubuj, Daniel Dmowski   +9 more
doaj   +3 more sources

Brincidofovir Effectively Inhibits Proliferation of Pseudorabies Virus by Disrupting Viral Replication

Viruses
Pseudorabies is an acute and febrile infectious disease caused by pseudorabies virus (PRV), a member of the family Herpesviridae. Currently, PRV is predominantly endemoepidemic and has caused significant economic losses among domestic pigs. Other animals
Huihui Guo, Qingyun Liu, Dan Yang, Hao Zhang, Yan Kuang, Yafei Li, Huanchun Chen, Xiangru Wang   +7 more
doaj   +3 more sources

Disseminated Mpox infection, a rare case of an immunocompromised patient treated with tecovirimat and brincidofovir [PDF]

JAAD Case Reports
Paytra A. Klein, MBA, Rose Parisi, MD, Ananthakrishnan Ramani, MD   +2 more
doaj   +2 more sources

Mpox in South Asia: A Narrative Review on Epidemiology, Preparedness, and Preventive Strategies. [PDF]

Health Sci Rep
ABSTRACT Background and Aims Monkeypox (Mpox), due to its growing global concern, was declared a public health emergency of worldwide concern by the World Health Organization in August 2024. The monkeypox virus (MPXV), once limited to African regions, has now spread to South Asia, including Pakistan, India, Nepal, and Sri Lanka, and there have been ...
Mawa J, Rimun SN, Rahman NZ, Bhuiyan MA, Shahriar M, Anjum R.   +5 more
europepmc   +2 more sources

Battle won, war ongoing: A call for mpox vaccination in high-risk dermatologic cases [PDF]

JAAD Case Reports
Atika Malik, MD, Monique Kumar, MD, Tien-Anh N. Tran, MD, Timmy Do, PharmD, BCPS, BCIDP, Lindsay Lim, MD, DTMH   +4 more
doaj   +2 more sources

Brincidofovir is a robust replication inhibitor against African swine fever virus in vivo and in vitro

Emerging Microbes and Infections, 2023
African swine fever virus (ASFV) infection is a major public and socioeconomic concern that has a serious impact on the global swine industry. Unfortunately, there are currently no commercially available vaccines or antiviral agents that are both safe ...
Shibang Guo, Yibo Zhang, Zhankui Liu, Daozhong Wang, Hui Liu, Liang Li, Qichao Chen, Dan Yang, Qingyun Liu, Huihui Guo, Shuang Mou, Huanchun Chen, Xiangru Wang   +12 more
doaj   +1 more source

Antivirals against Monkeypox (Mpox) in Humans: An Updated Narrative Review

Life, 2023
As of 29 August 2023, a total of 89,596 confirmed cases of Mpox (monkeypox) have been documented across 114 countries worldwide, with 157 reported fatalities.
Giuseppe Bruno, Giovanni Battista Buccoliero   +1 more
doaj   +1 more source