Results 11 to 20 of about 1,825 (158)

Concurrent Mpox and HSV-1 Proctitis in a Young Male With AIDS: A Case Report of Treatment Failure [PDF]

Case Reports in Infectious Diseases
Managing the mpox in patients with advanced HIV infection and coinfections poses significant challenges. This report discusses a young male with advanced HIV (CD4 count 28) and severe concurrent mpox and HSV-1 proctitis.
Mikhail Sukhoroslov, Fouad Kaddour-Hocine, Muhammad Hammad Ashraf, Navya Mandalapu, Shivani Bansal, Matthew Peachey   +5 more
doaj   +2 more sources

On topological co-index polynomials for predictive modeling of the physicochemical properties of antiviral drugs [PDF]

Scientific Reports
This study investigates the potential of topological co-indices and their polynomials as computational tools for predicting the physicochemical properties of antiviral compounds targeting the Ebola virus.
Summeira Meharban, Asad Ullah, Shahid Zaman, Assmaa Abd-Elmonem, Parvez Ali, Neissrien Alhubieshi, Melaku Berhe Belay   +6 more
doaj   +2 more sources

Brincidofovir in the Era of Mpox

Expert Review of Anti-Infective Therapy
Mpox (formerly monkeypox), a systemic infection caused by the mpox virus (MPXV), has become a global problem of increasing concern. There are currently no antiviral treatments that have been shown to be safe and effective for the treatment of mpox.Brincidofovir is a lipid-modified acyclic nucleotide with in vitro and in vivo activity against multiple ...
James, McCarty, David, Cassie, Shantha, Kodihalli, Efe, Aigbedo, Jing, Tian, Kevin, Yeo, Vanja, Komlenovic, Lovelyn, Charles, Bojan, Drobic, Bob, Warnock   +9 more
exaly   +3 more sources

Broad-spectrum antiviral brincidofovir inhibits Epstein-Barr virus and related gammaherpesvirus in human and nonhuman primate cells [PDF]

The Journal of Clinical Investigation
Epstein-Barr virus (EBV) is of growing interest for its potential role in neurodegenerative diseases such as multiple sclerosis (MS) and its possible utility as a therapeutic target in herpesvirus-associated chronic diseases. The effects of brincidofovir
Abaigeal Donaldson, Madeleine R. Druker, Maria Chiara Monaco, Emily H. Stack, Paige Zimmerman, Amanda Lee, Izabela Bialuk, William Frazier, Irene Cortese, Heather Narver, Masatoshi Hazama, Fuminori Yoshida, Xiaofan Li, Laurie T. Krug, Stacey L. Piotrowski, Steven Jacobson   +15 more
doaj   +2 more sources

Novel derivatives of brincidofovir and (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine inhibit orthopoxviruses and human adenoviruses more potently than brincidofovir

Signal Transduction and Targeted Therapy
Brincidofovir (BCV) and tecovirimat are the only two chemical drugs that have been approved to treat smallpox and can be requested for monkeypox (Mpox) treatment through a single-patient Emergency Investigational New Drug (EIND) application ...
Yifan Zhang, Yanmin Wan, Cuiyuan Guo, Zhaoqin Zhu, Chao Qiu, Jiasheng Lu, Yanan Zhou, Jiaojiao Zheng, Fahui Dai, Xiaoyang Cheng, Kunlu Deng, Wanhai Wang, Youchun Wang, Wenhong Zhang   +13 more
doaj   +3 more sources

Disseminated Mpox infection, a rare case of an immunocompromised patient treated with tecovirimat and brincidofovir [PDF]

JAAD Case Reports
Paytra A. Klein, MBA, Rose Parisi, MD, Ananthakrishnan Ramani, MD   +2 more
doaj   +2 more sources

Brincidofovir Effectively Inhibits Proliferation of Pseudorabies Virus by Disrupting Viral Replication

Viruses
Pseudorabies is an acute and febrile infectious disease caused by pseudorabies virus (PRV), a member of the family Herpesviridae. Currently, PRV is predominantly endemoepidemic and has caused significant economic losses among domestic pigs. Other animals
Huihui Guo, Qingyun Liu, Dan Yang, Hao Zhang, Yan Kuang, Yafei Li, Huanchun Chen, Xiangru Wang   +7 more
doaj   +3 more sources

Trends of Pathogenicity and Potential Risk Evaluation of Central African Mpox Variant to Cause Global Public Health Emergency: A Cross-Sectional Analysis. [PDF]

Health Sci Rep
ABSTRACT Background With the re‐emergence of monkeypox (Mpox), it is vital for communities to assess and effectively respond to emerging outbreaks. This paper aims to review the potential of clade I Mpox to result in a widespread outbreak by assessing genetically enhanced virulence, transmission, and clinical manifestations.
Rahman MA, Kozlowich C, Katulka N, Thomas MR, Shanjana Y, Islam MR.   +5 more
europepmc   +2 more sources

Battle won, war ongoing: A call for mpox vaccination in high-risk dermatologic cases [PDF]

JAAD Case Reports
Atika Malik, MD, Monique Kumar, MD, Tien-Anh N. Tran, MD, Timmy Do, PharmD, BCPS, BCIDP, Lindsay Lim, MD, DTMH   +4 more
doaj   +2 more sources

Mpox in South Asia: A Narrative Review on Epidemiology, Preparedness, and Preventive Strategies. [PDF]

Health Sci Rep
ABSTRACT Background and Aims Monkeypox (Mpox), due to its growing global concern, was declared a public health emergency of worldwide concern by the World Health Organization in August 2024. The monkeypox virus (MPXV), once limited to African regions, has now spread to South Asia, including Pakistan, India, Nepal, and Sri Lanka, and there have been ...
Mawa J, Rimun SN, Rahman NZ, Bhuiyan MA, Shahriar M, Anjum R.   +5 more
europepmc   +2 more sources