Results 41 to 50 of about 2,019 (146)

Special Populations in Pivotal Clinical Trials: Eligibility and Supporting Evidence for Exclusion in EMA‐Authorised Medicines

Clinical Pharmacology &Therapeutics, EarlyView.
Evidence on the efficacy and safety of medicines supporting marketing authorization is largely derived from randomized controlled trials, yet these trials often exclude populations likely to use the medications in clinical practice. This study assessed eligibility of special populations, defined as pregnant and breast‐feeding individuals, elderly ...
Maja J. Jørgensen, Débora D. Gräf, Christine E. Hallgreen   +2 more
wiley   +1 more source

Boosted Tecovirimat Injection for Orthopoxvirus Infection Therapy

Engineering
Since 2022, global mpox outbreaks have resulted in 172 510 confirmed cases and 462 deaths as of October 31, 2025. Tecovirimat, a small-molecule therapeutic agent for orthopoxvirus infections (e.g., smallpox and mpox), is clinically limited owing to its ...
Yaqin Sun, Cheng Niu, Guangyan Sun, Xinyuan Zhao, Suyue Zhang, Zaiwei Zong, Wei Wang, Feiqiang Chen, Tianyi Fan, Na Liu, Shaoting Qiu, Yani Li, Xupeng Wei, Yunzheng Yan, Shuyuan Pan, Wu Zhong, Yuntao Zhang, Song Li   +17 more
doaj   +1 more source

Case report: From monkeypox pharyngitis to myopericarditis and atypical skin lesions

Frontiers in Cardiovascular Medicine, 2023
BackgroundA global outbreak of the human monkeypox virus (HMPXV), first identified in May 2022, was declared a health emergency of international concern on 23 July 2022. Before the global outbreak, monkeypox cases were mostly confined to central and west
María Ascensión Sanromán Guerrero, Elena Hernández Sánchez, Belén de Nicolás Ruanes, Pablo Fernández-González, Sonia Antoñana Ugalde, Alejandra González Leal, Marcelo Sanmartín Fernández, Jose Javier Alarcón Rodríguez, Laura Martinez Garcia, Rosa Escudero, Maria Ángeles Fernández Méndez, Jose Luis Zamorano Gómez, Beatriz Montero Llorente, Maria Jesús Vivancos-Gallego   +13 more
doaj   +1 more source

Molecular glues: Recent advances in cereblon substrate identification and mechanistic insights

Smart Molecules, EarlyView.
Molecular glues exert diverse core biological functions by inducing or stabilizing protein–protein interactions, extending far beyond the traditional scope of targeted protein degradation. Key breakthroughs include expanded cereblon substrate recognition, sustained G protein‐coupled receptor megacomplex signaling, and the first orthosteric molecular ...
Qingyun Guan, Xiaoyu Shi, Qian Yang, Xiangyi Jiang, Xinyong Liu, Peng Zhan   +5 more
wiley   +1 more source

Battle won, war ongoing: A call for mpox vaccination in high-risk dermatologic cases [PDF]

JAAD Case Reports
Atika Malik, MD, Monique Kumar, MD, Tien-Anh N. Tran, MD, Timmy Do, PharmD, BCPS, BCIDP, Lindsay Lim, MD, DTMH   +4 more
doaj   +2 more sources

Genomic Epidemiology and Clinical Characteristics of Mpox Lineage C.1 Outbreak in Thailand, 2023–2024

Journal of Medical Virology, Volume 98, Issue 9, September 2026.
ABSTRACT Since 2022, human monkeypox virus (hMPXV) has emerged in non‐endemic regions, including Thailand. However, the genomic dynamics and clinical correlates of local transmission remain incompletely defined. Whole‐genome sequencing was performed on hMPXV from 16 patients in Thailand (2023–2024) using targeted amplicon NGS.
Kamol Suwannakarn, Chutikarn Chaimayo, Atsadang Boonmee, Charussri Leeyaphan, Pattriya Jirawattanadon, Pravarit Athiprayoon, Natsada Saengdao, Piyarat Taiphakphaibun, Chutima Deetippasert, Warinya Nuwong, Niracha Athipanyasilp, Archiraya Pattama, Navin Horthongkham   +12 more
wiley   +1 more source

Monkeypox in human pregnancy: an overview

AJOG Global Reports, 2022
Monkeypox is a viral zoonosis caused by the monkeypox virus, an enveloped, double-stranded DNA virus belonging to the Orthopoxvirus genus in the Poxviridae family. Monkeypox has become a disease of global public health significance.
Sulaiman Muhammad Daneji, MBBS, FWACS, Aliyu Aminu, MBBS, FMCPath, Awwal Musa Borodo, MBBS, MSc, FWACP, FMCPath, Farouq Muhammad Dayyab, MBBS, MPH, FMCP   +3 more
doaj   +1 more source

Early Mpox Detection: Integrating Skin Lesion Imaging, Epidemiology, and Treatment for Deep Learning Approaches

Medicine Advances, Volume 4, Issue 3, Page 287-296, September 2026.
Research papers utilizing publicly available, web‐scraped resources related to mpox—including news portals and datasets such as Monkeypox2022, Kaggle, and the Monkeypox Skin Images Dataset—demonstrate variability in accuracy. Our findings suggest that although deep learning models such as MobileNetV2, VGG16, and GoogLeNet report accuracy exceeding 95%,
Taskin Sabit, Faiza Tasnim
wiley   +1 more source

Tecovirimat: A journey from discovery to mechanistic insights in poxvirus inhibition.

PLoS Pathogens
Tecovirimat (ST-246 or TPOXX) is an antiviral agent developed as part of a U.S. biodefense initiative aimed at addressing Orthopoxvirus infections, including smallpox and mpox.
Xue Li, Zhengyang Pan, Leiliang Zhang
doaj   +1 more source

Identification of Repurposed Drugs Against Monkeypox Virus Through Comprehensive Virtual Screening

Biotechnology Journal, Volume 21, Issue 8, August 2026.
Graphical Abstract and Lay Summary By combining interspecies protein analysis with advanced virtual screening, this study identifies potent repurposed drug candidates—including vindesine and LY2090314—targeting mpox DNA topoisomerase and polymerase. This workflow provides a rapid, practical framework for antiviral discovery against emerging infectious ...
Taeho Yu, Woo Dae Jang, Sang Yup Lee
wiley   +1 more source