Results 31 to 40 of about 2,019 (146)

Short Note on Tecovirimat

Journal of Pharmaceutical Research International, 2021
Smallpox, an infectious disease, caused by one of the two virus variants, Variola major and Variola minor. Smallpox is a highly contagious and fatal disease. The last case which occurred naturally was in October 1977. The disease was eradicated globally by the World Health Organisation in the year 1980.
C. Sushil, S. Padmaja
openaire   +2 more sources

Monkeypox: a global health emergency

Frontiers in Microbiology, 2023
Over the past 2 years, the world has faced the impactful Coronavirus Disease-2019 (COVID-19) pandemic, with a visible shift in economy, medicine, and beyond.
Ruxandra Ilinca Stilpeanu, Ruxandra Ilinca Stilpeanu, Ana Maria Stercu, Ana Maria Stercu, Andreea Lucia Stancu, Antoanela Tanca, Antoanela Tanca, Octavian Bucur, Octavian Bucur, Octavian Bucur   +9 more
doaj   +1 more source

Antivirals against Monkeypox (Mpox) in Humans: An Updated Narrative Review

Life, 2023
As of 29 August 2023, a total of 89,596 confirmed cases of Mpox (monkeypox) have been documented across 114 countries worldwide, with 157 reported fatalities.
Giuseppe Bruno, Giovanni Battista Buccoliero   +1 more
doaj   +1 more source

Overcoming barriers, driving progress: Clinical science at IAS 2025. [PDF]

J Int AIDS Soc
Abstract Introduction The 13th IAS Conference on HIV Science, held in Kigali, Rwanda (13–17 July 2025), highlighted key advances in clinical research. Presentations focused on sustaining HIV treatment and prevention amid financial constraints, innovations in long‐acting oral antiretrovirals, and the management of comorbidities and co‐infections ...
Cordova E, Sokhela S, Alagaratnam J, Ambrosioni J.   +3 more
europepmc   +2 more sources

Acute respiratory distress syndrome due to monkeypox virus

European Journal of Case Reports in Internal Medicine, 2023
We report the first case of monkeypox virus (MPXV) associated acute respiratory distress syndrome (ARDS). A 34-year-old French woman with no medical history was admitted to the intensive care unit (ICU) for fever, altered mental status, hypotension and ...
Tona Tchoubou, Rima El-Hosni, Marion Dollat, Pierre Jaquet, Celine Tournus, Yacine Tandjaoui-Lambiotte, Daniel Da Silva   +6 more
doaj   +1 more source

VP37 Protein Inhibitors for Mpox Treatment: Highlights on Recent Advances, Patent Literature, and Future Directions

Biomedicines, 2023
Monkeypox disease (Mpox) has threatened humankind worldwide since mid-2022. The Mpox virus (MpoxV) is an example of Orthopoxviruses (OPVs), which share similar genomic structures. A few treatments and vaccines are available for Mpox.
Shuaibu A. Hudu, Ahmed S. Alshrari, Aiman Al Qtaitat, Mohd Imran   +3 more
doaj   +1 more source

Comprehensive update on the monkeypox outbreak

Frontiers in Microbiology, 2022
Monkeypox (MPX) was first reported in 1970 in humans and outbreaks were restricted and highly localised to endemic regions of western and central Africa.
Asad Mustafa Karim, Jeong Eun Kwon, Mujahid Aizaz Karim, Haseeb Iftikhar, Muhammad Yasir, Muhammad Yasir, Irfan Ullah, Se Chan Kang   +7 more
doaj   +1 more source

Development and Validation of a Method of Liquid Chromatography Coupled with Tandem Mass Spectrometry for Quantification of ST-246 (Tecovirimat) in Human Plasma

Molecules, 2022
The aim of this work was to develop and validate a sensitive and robust method of liquid chromatography coupled with tandem mass spectrometry to quantitate ST-246 (tecovirimat) in plasma using an internal standard (2-hydroxy-N-{3,5-dioxo-4-azatetracyclo [
Galina A. Oleinik, Vladimir V. Koval, Svetlana V. Usova, Larisa N. Shishkina, Alexander A. Chernonosov   +4 more
doaj   +1 more source

Tecovirimat for the treatment of severe Mpox in Germany

Infection, 2023
Abstract Background In May 2022, a multi-national mpox outbreak was reported in several non-endemic countries. The only licensed treatment for mpox in the European Union is the orally available small molecule tecovirimat, which in Orthopox viruses inhibits the function of a major envelope protein required for the ...
Hermanussen, Lennart, Brehm, Thomas Theo, Wolf, Timo, Boesecke, Christoph, Schlabe, Stefan, Borgans, Frauke, Monin, Malte B., Jensen, Björn-Erik Ole, Windhaber, Stefan, Scholten, Stefan, Jordan, Sabine, Lütgehetmann, Marc, Schulze zur Wiesch, Julian, Addo, Marylyn M., Mikolajewska, Agata, Niebank, Michaela, Schmiedel, Stefan   +16 more
openaire   +3 more sources

Targeting β2‐Adrenergic Receptor Stability With Lycorine Reveals a Host‐Directed Pathway for Antiviral Defense Against Poxviruses

Advanced Science, EarlyView.
Chronic stress drives autophagy‐mediated β2‐AR degradation, impairing antiviral immunity and promoting poxvirus lethality. Lycorine directly stabilizes β2‐AR to restore host defense, suppress excessive inflammation and improve survival. ABSTRACT Psychological stress is a pervasive yet poorly understood modulator of infectious disease outcomes. Here, we
Xin Zhang, Shuqin Xu, Zixuan Zhang, Chenwen Wan, Xiaoqin Wang, Peihua Wang, Huini Yang, Tianxiao Huang, Yijia Yuan, Faiza Atique, Rui Yang, Yingli He, Zhijun Liu   +12 more
wiley   +1 more source