Results 11 to 20 of about 1,939 (155)
Assessment of three antiviral compounds against Borealpox virus infection in a mouse model [PDF]
Emerging Microbes and InfectionsBorealpox virus (BRPV) is a zoonotic orthopoxvirus which was first documented in Alaska in 2015. Although most human infections are mild, a recent fatal case in an immunocompromised individual highlights the importance of studying this emerging pathogen.
Jérémie Prévost +7 more
doaj +2 more sources
Tecovirimat: A journey from discovery to mechanistic insights in poxvirus inhibition. [PDF]
PLoS PathogensTecovirimat (ST-246 or TPOXX) is an antiviral agent developed as part of a U.S. biodefense initiative aimed at addressing Orthopoxvirus infections, including smallpox and mpox.
Xue Li, Zhengyang Pan, Leiliang Zhang
doaj +2 more sources
Eczema Monkeypoxicum Following Sexual Transmission Treated With Tecovirimat
JEADV Clinical PracticeMpox is a zoonotic viral infection caused by monkeypox virus (MPXV) and risk factors for its dissemination include previous dermatoses such as atopic dermatitis [1].
Andrés Vidal González +6 more
doaj +2 more sources
Molecules, 2022 The aim of this work was to develop and validate a sensitive and robust method of liquid chromatography coupled with tandem mass spectrometry to quantitate ST-246 (tecovirimat) in plasma using an internal standard (2-hydroxy-N-{3,5-dioxo-4-azatetracyclo [
Alexander Chernonosov +2 more
exaly +3 more sources
Evaluating the advancements and efficacies in pharmacological Mpox treatments: a comprehensive review [PDF]
Frontiers in PharmacologyMonkeypox, now known as Mpox, has reemerged as a serious public health threat due to an increasing number of outbreaks outside its primary endemic regions. Although virologically similar to smallpox, smallpox therapy is not specifically approved for Mpox.
Shuaibu Abdullahi Hudu +6 more
doaj +2 more sources
Ocular mpox presenting as sclerokeratouveitis: A case report [PDF]
IDCasesPurpose: To describe a case of mpox-associated ocular disease in an HIV-infected patient. Case report: A 50-year-old man presented with severe ocular inflammation including corneal ulceration, scleral involvement and anterior uveitis.
N. Domènech-López +6 more
doaj +2 more sources
International Journal of Infectious Diseases, 2022 A patient aged 28 years who is immunocompromised and living with HIV/AIDS became infected with the monkeypox virus (MPXV). His clinical condition deteriorated for 37 days, with fever, skin lesions, and diarrhea before going to the infectious diseases ...
Xavier Boumaza +2 more
exaly +3 more sources
Repurposed Medicines for Viruses With Epidemic or Pandemic Potential: A Horizon Scan. [PDF]
Pharmacol Res PerspectABSTRACT Viruses such as Ebola, Marburg, influenza, mpox, MERS‐CoV, SARS‐CoV, and SARS‐CoV‐2 may be considered pathogens of epidemic or pandemic concern. Developing novel antiviral medicines can be time‐consuming and resource intensive. Repurposing existing medicines with known or potential antiviral activity offers a faster, cost‐effective strategy to
Akinbolade S +5 more
europepmc +2 more sources
Pharmacokinetics of tecovirimat in subjects with Mpox
International Journal of Antimicrobial AgentsTo investigate the pharmacokinetics (PK) of tecovirimat in subjects with Mpox.This monocentric, prospective, observational study enrolled subjects with Mpox who received standard treatment with oral tecovirimat. Plasma samples for PK assessment were collected at steady state (5-8 days after initiation of antiviral therapy), before and 3, 5, 7 and 12 h ...
Valentina Mazzotta +2 more
exaly +3 more sources
Tecovirimat-Related Substance: Characterization, Hirshfeld Analysis, Theoretical Study, In Silico Toxicity Assessment [PDF]
MoleculesCrystal structures of 4-(trifluoromethyl)benzene-1-carbohydrazide (1), 4-(trifluoromethyl)-N’-{[4-(trifluoromethyl)phenyl]carbonyl}benzohydrazide (2) and (1R,2S,6R,7S,8S,10R)-4-({[4-(trifluoromethyl)phenyl]carbonyl}amino)-4-azatetracyclo [5.3.2.08,10.02 ...
Fengfeng Wang +5 more
doaj +2 more sources