Results 11 to 20 of about 3,580 (135)

Nitroxoline evidence amoebicidal activity against Acanthamoeba castellanii through DNA damage and the stress response pathways [PDF]

International Journal for Parasitology: Drugs and Drug Resistance
Acanthamoeba castellanii is a widespread unicellular eukaryote found in diverse environments, including tap water, soil, and swimming pools. It is responsible for severe infections, such as Acanthamoeba keratitis and granulomatous amebic encephalitis ...
Lijun Chen, Wei Han, Wenwen Jing, Meng Feng, Qingtong Zhou, Xunjia Cheng   +5 more
doaj   +2 more sources

Potential anti-amoebic effects of synthetic 1,4-benzothiazine derivatives against Acanthamoeba castellanii [PDF]

Heliyon
A rare but lethal central nervous system disease known as granulomatous amoebic encephalitis (GAE) and potentially blinding Acanthamoeba keratitis are diseases caused by free-living Acanthamoeba.
Alishba, Usman Ahmed, Muhammad Taha, Naveed Ahmed Khan, Uzma Salar, Khalid Mohammed Khan, Ayaz Anwar, Ruqaiyyah Siddiqui   +7 more
doaj   +2 more sources

Detection of Acanthamoeba spp. using carboxylesterase antibody and its usage for diagnosing Acanthamoeba-keratitis

PLoS ONE, 2022
Contact lens usage has contributed to increased incidence rates of Acanthamoeba keratitis (AK), a serious corneal infection that can lead to blindness.
Min-Jeong Kim, Ki-Back Chu, Hae-Ahm Lee, Fu-Shi Quan, Hyun-Hee Kong, Eun-Kyung Moon   +5 more
doaj   +3 more sources

Commensals Serve as Natural Barriers to Mammalian Cells during Acanthamoeba castellanii Invasion

Microbiology Spectrum, 2021
Acanthamoeba castellanii is a free-living, pathogenic ameba found in the soil and water. It invades the body through ulcerated skin, the nasal passages, and eyes and can cause blinding keratitis and granulomatous encephalitis.
Yu-Jen Wang, Chun-Hsien Chen, Jenn-Wei Chen, Wei-Chen Lin   +3 more
doaj   +1 more source

Pathogenic strains of Acanthamoeba are recognized by TLR4 and initiated inflammatory responses in the cornea. [PDF]

PLoS ONE, 2014
Free-living amoebae of the Acanthamoeba species are the causative agent of Acanthamoeba keratitis (AK), a sight-threatening corneal infection that causes severe pain and a characteristic ring-shaped corneal infiltrate.
Hassan Alizadeh, Trivendra Tripathi, Mahshid Abdi, Ashley Dawn Smith   +3 more
doaj   +1 more source

Metronidazole conjugated magnetic nanoparticles loaded with amphotericin B exhibited potent effects against pathogenic Acanthamoeba castellanii belonging to the T4 genotype

AMB Express, 2020
Acanthamoeba castellanii can cause granulomatous amoebic encephalitis and Acanthamoeba keratitis. Currently, no single drug has been developed to effectively treat infections caused by Acanthamoeba.
Sumayah Abdelnasir, Ayaz Anwar, Muhammad Kawish, Areeba Anwar, Muhammad Raza Shah, Ruqaiyyah Siddiqui, Naveed Ahmed Khan   +6 more
doaj   +1 more source

Transcriptional changes of proteins of the thioredoxin and glutathione systems in Acanthamoeba spp. under oxidative stress – an RNA approach

Parasite, 2022
The thioredoxin (Trx) and the glutathione (GSH) systems represent important antioxidant systems in cells and in particular thioredoxin reductase (TrxR) has been shown to constitute a promising drug target in parasites.
Köhsler Martina, Leitsch David, Loufouma Mbouaka Alvie, Wekerle Maximilian, Walochnik Julia   +4 more
doaj   +1 more source

Chemiluminescence of Acanthamoeba castellanii [PDF]

Biochemical Journal, 1979
1. Chemiluminescence of Acanthomoeba castellanii in the presence of O2 was of similar intensity in organisms harvested early or late during exponential growth [when cyanide (1 mM) stimulates or inhibits respiration respectively]. 2. Cyanide (up to 1.5 mM) stimulated photoemission in both types of organism by 250–300 photons/s per 10(7) cells above the ...
D, Lloyd, A, Boveris, R, Reiter, M, Filipkowski, B, Chance   +4 more
openaire   +2 more sources

Isoniazid Conjugated Magnetic Nanoparticles Loaded with Amphotericin B as a Potent Antiamoebic Agent against Acanthamoeba castellanii

Antibiotics, 2020
The pathogenic free-living amoeba, Acanthamoeba castellanii, is responsible for a rare but deadly central nervous system infection, granulomatous amoebic encephalitis and a blinding eye disease called Acanthamoeba keratitis.
Kawish Iqbal, Sumayah Abdelnasir Osman Abdalla, Ayaz Anwar, Kanwal Muhammad Iqbal, Muhammad Raza Shah, Areeba Anwar, Ruqaiyyah Siddiqui, Naveed Ahmed Khan   +7 more
doaj   +1 more source

Encystment Induces Down-Regulation of an Acetyltransferase-Like Gene in Acanthamoeba castellanii

Pathogens, 2020
Acanthamoeba castellanii is a ubiquitous free-living amoeba. Pathogenic strains are causative agents of Acanthamoeba keratitis and granulomatous amoebic encephalitis. In response to adverse conditions, A.
Steven Rolland, Luce Mengue, Cyril Noël, Stéphanie Crapart, Anne Mercier, Willy Aucher, Yann Héchard, Ascel Samba-Louaka   +7 more
doaj   +1 more source