Results 11 to 20 of about 5,263 (211)

The Anti-Amoebic Activity of a Peptidomimetic against Acanthamoeba castellanii

Microorganisms, 2022
Acanthamoeba is a free-living protozoan known to cause keratitis most commonly, especially among contact lens wearers. Treatment of Acanthamoeba keratitis is challenging as Acanthamoeba can encyst from the active form, a trophozoite, into a hibernating ...
Hari Kumar Peguda, Nicole A. Carnt, Zi Gu, Naresh Kumar, Mark D. P. Willcox, Rajesh Kuppusamy   +5 more
doaj   +4 more sources

Encystment Induces Down-Regulation of an Acetyltransferase-Like Gene in Acanthamoeba castellanii

Pathogens, 2020
Acanthamoeba castellanii is a ubiquitous free-living amoeba. Pathogenic strains are causative agents of Acanthamoeba keratitis and granulomatous amoebic encephalitis. In response to adverse conditions, A.
Steven Rolland, Luce Mengue, Cyril Noël, Stéphanie Crapart, Anne Mercier, Willy Aucher, Yann Héchard, Ascel Samba-Louaka   +7 more
doaj   +2 more sources

Establecimiento de protocolos de cultivo y mantenimiento de Acanthamoeba castellanii

Cedamaz
El género Acanthamoeba abarca diversas especies de amebas de vida libre, se aíslan con frecuencia de distintas fuentes ambientales como el agua, el suelo y el aire. Varias especies son conocidas por causar infecciones y enfermedades en humanos y animales.
Daniela Román, Ana Claudia Samaniego-Villacís, Adamary Vásquez-Tituana, Jorge Armijos Rivera   +3 more
doaj   +2 more sources

The role of proteases in the differentiation ofAcanthamoeba castellanii [PDF]

FEMS Microbiology Letters, 2008
Proteases are significant determinants of protozoan pathogenicity and cytolysis of host cells. However, there is now growing evidence of their involvement in cellular differentiation. Acanthamoeba castellanii of the T4 genotype elaborates a number of proteases, which are inhibited by the serine protease inhibitor phenylmethylsulphonyl fluoride.
Dudley, R, Alsam, S, Khan, NA
openaire   +4 more sources

Stable transfection of Acanthamoeba castellanii

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2005
A simple method for stable transfection of Acanthamoeba castellanii using plasmids which confer resistance to neomycin G418 is described. Expression of neomycin phosphotransferase is driven by the Acanthamoeba TBP gene promoter, and can be monitored by cell growth in the presence of neomycin G418 or by Western blot analysis.
Peng, Zhihua, Omaruddin, Romaica, Bateman, Erik   +2 more
openaire   +3 more sources

Nitroxoline evidence amoebicidal activity against Acanthamoeba castellanii through DNA damage and the stress response pathways [PDF]

International Journal for Parasitology: Drugs and Drug Resistance
Acanthamoeba castellanii is a widespread unicellular eukaryote found in diverse environments, including tap water, soil, and swimming pools. It is responsible for severe infections, such as Acanthamoeba keratitis and granulomatous amebic encephalitis ...
Lijun Chen, Wei Han, Wenwen Jing, Meng Feng, Qingtong Zhou, Xunjia Cheng   +5 more
doaj   +2 more sources

Detection of Acanthamoeba spp. using carboxylesterase antibody and its usage for diagnosing Acanthamoeba-keratitis

PLoS ONE, 2022
Contact lens usage has contributed to increased incidence rates of Acanthamoeba keratitis (AK), a serious corneal infection that can lead to blindness.
Min-Jeong Kim, Ki-Back Chu, Hae-Ahm Lee, Fu-Shi Quan, Hyun-Hee Kong, Eun-Kyung Moon   +5 more
doaj   +3 more sources

Acanthamoeba castellanii Can Facilitate Plasmid Transfer Between Environmental Pseudomonas spp. [PDF]

J Basic Microbiol
ABSTRACT The conditions in which antimicrobial resistance (AMR) genes are transferred in natural environments are poorly understood. Acanthamoeba castellanii (a cosmopolitan environmental amoeba) feeds on bacteria by phagocytosis, which places the consumed bacteria closely together in a food vacuole (phagosome) of the amoeba.
Sarink MJ, Grassi L, Tielens AGM, Verbon A, Vos MC, Goessens W, Strepis N, Klaassen CHW, van Hellemond JJ.   +8 more
europepmc   +2 more sources

Pathogenic strains of Acanthamoeba are recognized by TLR4 and initiated inflammatory responses in the cornea. [PDF]

PLoS ONE, 2014
Free-living amoebae of the Acanthamoeba species are the causative agent of Acanthamoeba keratitis (AK), a sight-threatening corneal infection that causes severe pain and a characteristic ring-shaped corneal infiltrate.
Hassan Alizadeh, Trivendra Tripathi, Mahshid Abdi, Ashley Dawn Smith   +3 more
doaj   +1 more source

Metronidazole conjugated magnetic nanoparticles loaded with amphotericin B exhibited potent effects against pathogenic Acanthamoeba castellanii belonging to the T4 genotype

AMB Express, 2020
Acanthamoeba castellanii can cause granulomatous amoebic encephalitis and Acanthamoeba keratitis. Currently, no single drug has been developed to effectively treat infections caused by Acanthamoeba.
Sumayah Abdelnasir, Ayaz Anwar, Muhammad Kawish, Areeba Anwar, Muhammad Raza Shah, Ruqaiyyah Siddiqui, Naveed Ahmed Khan   +6 more
doaj   +1 more source