Results 91 to 100 of about 354,268 (327)
SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1
FEBS Open Bio, EarlyView.Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl +13 more
wiley +1 more source
Viability of Soybean Seeds (Glycine Max [L.] Merr.) Varieties Argomulyo and Dena-1 Due to the Exposed on Saturated Steam or Stored at Low Temperatures [PDF]
, 2019 The viability of the seed will be lower if stored longer, as well as seeds that are given the higher intensity of accelerated aging treatment. Is the decrease in viability of the Argomulyo and Dena-1 varieties of soybean seeds during the 0-6 month ...
Hilleri, O. (Okvi) +2 more
core
Biomarkers of aging associated with past treatments in breast cancer survivors. [PDF]
, 2017 Radiation and chemotherapy are effective treatments for cancer, but are also toxic to healthy cells. Little is known about whether prior exposure to these treatments is related to markers of cellular aging years later in breast cancer survivors.
Bower, Julienne E +11 more
core +2 more sources
FEBS Open Bio, EarlyView.Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid +3 more
wiley +1 more source
Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications
FEBS Open Bio, EarlyView.This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley +1 more source
Physiological and biochemical quality of paradise nut seed
Pesquisa Agropecuária BrasileiraThe objective of this work was to evaluate the physiological quality of Lecythis pisonis seed and their biochemical changes after being subjected to accelerated aging.
Caroline Palacio de Araujo +8 more
doaj +1 more source
The role of lipid metabolism in neuronal senescence
FEBS Open Bio, EarlyView.Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari +2 more
wiley +1 more source
Computer modeling of photodegradation [PDF]
A computer program to simulate the photodegradation of materials exposed to terrestrial weathering environments is being developed. Input parameters would include the solar spectrum, the daily levels and variations of temperature and relative humidity ...
Guillet, J.
core +1 more source
Natural and simulated aging of historical glasses [PDF]
, 2017 We thoroughly studied coloured glass tesserae of historical glass windows of the Santi Giovanni e Paolo Church in Venice by means of ESEM and XPS techniques in order to evaluate the weathering mechanisms of the glass surfaces.
Bertoncello, Renzo, Elena, Rebollo
core +1 more source
The additive impact of
, 2022 Meghann C. Ryan +16 more
openalex +1 more source