Results 31 to 40 of about 9,228,267 (373)
Accelerated epigenetic aging in Werner syndrome. [PDF]
, 2017 Individuals suffering from Werner syndrome (WS) exhibit many clinical signs of accelerated aging. While the underlying constitutional mutation leads to accelerated rates of DNA damage, it is not yet known whether WS is also associated with an increased ...
Flunkert, Julia +5 more
core +1 more source
Accelerated epigenetic aging in newborns with Down syndrome
Aging Cell, 2022 Accelerated aging is a hallmark of Down syndrome (DS), with adults experiencing early‐onset Alzheimer's disease and premature aging of the skin, hair, and immune and endocrine systems.
Keren Xu +16 more
semanticscholar +1 more source
Mitochondrial Dysfunction Accelerates Ageing
Immunometabolism, 2020 Abstract We review here the seminal findings of Desdin-Mico et al. showing that T cells with dysfunctional mitochondria induce multimorbity and premature senescence, due to mitochondrial transcription factor A (TFAM). They add further weight to the idea that targeting immunometabolism could be beneficial in combating the ...
Schroth, J, Henson, SM
openaire +4 more sources
Accelerated aging in older cancer survivors
Journal of The American Geriatrics Society, 2021 We are experiencing an unprecedented growth in the number of older adults diagnosed with, and surviving from, cancer. By 2030, 70% of patients with cancer will be 65 years or older, and cancer incidence in this group will have increased by nearly 70 ...
M. Sedrak +3 more
semanticscholar +1 more source
Siglec receptors impact mammalian lifespan by modulating oxidative stress. [PDF]
, 2015 Aging is a multifactorial process that includes the lifelong accumulation of molecular damage, leading to age-related frailty, disability and disease, and eventually death. In this study, we report evidence of a significant correlation between the number
Fu, Xiaoming +16 more
core +1 more source
Age-Specific Acceleration of Cancer [PDF]
Current Biology, 2004 One of the great challenges of cancer research is to explain the epidemiological patterns of cancer incidence based on the molecular processes that lead to uncontrolled cellular proliferation. The epidemiological data demonstrate that the age-specific incidence of many cancers increases in an approximately linear way with age when plotted on a log-log ...
openaire +3 more sources
Journal of Clinical Investigation, 2020 Chronic inflammation is a pathologic feature of neurodegeneration and aging; however, the mechanism regulating this process is not understood. Melatonin, an endogenous free radical scavenger synthesized by neuronal mitochondria, decreases with aging and ...
A. Jauhari +12 more
semanticscholar +1 more source
Hygrothermal Studies on GFRP Composites: A Review
MATEC Web of Conferences, 2018 The objective of this paper is to review the hygrothermal environment effects on Glass Fiber Reinforced Polymer (GFRP) composites. A brief summary of the hygrothermal phenomenon and its mechanisms of GFRP is followed by detailed review of hygrothermal ...
Shettar Manjunath +4 more
doaj +2 more sources
Accelerated aging in lettuce seeds [PDF]
, 2011 Objetivou-se adequar a metodologia do teste de envelhecimento acelerado para avaliação do potencial fisiológico de sementes de quatro lotes dos genótipos de alface 'Babá de verão', 'Tainá' e 'Vera', aplicando-se o método tradicional e com o uso de ...
BARBOSA, Rafael Marani +2 more
core +3 more sources
The Link between Chronic Stress and Accelerated Aging
Biomedicines, 2020 People exposed to chronic stress age rapidly. The telomeres in their cells of all types shorten faster. Inflammation is another important feature of stress that, along with aging, accounts for the phenomenon of inflammaging.
Y. Yegorov +4 more
semanticscholar +1 more source