Results 91 to 100 of about 44,930 (304)

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

A new swelling - creep model for red-bed mudstone and its application

Frontiers in Earth Science
In the red-bed region, engineering structures often encounter safety risks due to the swelling and creep properties of mudstone. Presently, there is a deficiency in constitutive equations capable of characterizing mudstone behavior under combined stress ...
Hongyi Yan, Feng Yu, Chaobo Zhu, Jianwei Yuan, Qiang Wang, Jiang Wu   +5 more
doaj   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Creep dynamics of viscoelastic interfaces [PDF]

, 2013
The movement of a purely elastic interface driven on a disordered energy potential is characterized by a depinning transition: when the pulling force S is larger than some critical value S_1 the system is in a flowing regime and moves at a finite ...
Jagla, E. A.
core   +2 more sources

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

FEBS Open Bio, EarlyView.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi, Shunsuke Morioka, Keiko Morisawa, Kazutsugu Matsukawa, Shingo Ashida, Takeshi Suzuki, Shuji Sakamoto   +6 more
wiley   +1 more source

Static and dynamic aspects of coupling between creep behavior and oxidation on MC2 single crystal superalloy at 1150 °C [PDF]

, 2005
Creep tests were performed on thin wall specimens made of MC2 single crystal superalloy at 1150 °C and under controlled atmosphere. The results highlight the deleterious oxidation effect on creep properties.
Andrieu, Eric, Crabos, Fabrice, Dryepondt, Sébastien, Monceau, Daniel   +3 more
core   +2 more sources

Creep Effects on Creep Fatigue Crack Propagation of Center Cracked Plate and Attendant Acceleration/Retardation Phenomena.

TRANSACTIONS OF THE JAPAN SOCIETY OF MECHANICAL ENGINEERS Series A, 1997
A computational analysis addressing to the creep crack propagation problems is conducted. An incremental finite element procedure is developed and applied for investigating the creep effect on a fatigue crack propagation of a center cracked plate.
Seiya HAGIHARA, Michihiko NAKAGAKI
openaire   +2 more sources

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

Creep behaviour of sandstone under different water conditions and its response to varying impact energy

Geomatics, Natural Hazards & Risk
Creep deformation and failure of immersed sandstone under mining disturbances are critical factors driving water inrush and goaf collapse. This study employed a specialized creep-impact testing system capable of simultaneous water immersion and ...
Honglei Liu, Jianhua Zhou, Jinduo Li, Wenxue Deng, Leilei Niu, Tianhong Yang, Shixian Zhang   +6 more
doaj   +1 more source