Results 51 to 60 of about 44,930 (304)
Soils and Foundations, 2022 A technique for carbon dioxide (CO2) capture and storage using CO2 hydrates where CO2 is stored as solid hydrates in the seabed ground, is attracting attention.
Masaki Yoshimoto, Sayuri Kimoto
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Energy-based nonlinear damage creep model considering the influence of the concrete creep rate
Frontiers in MaterialsIn order to study the influence of confining pressure on the deformation of concrete, triaxial compression and creep tests under different confining pressures are carried out using a combination of laboratory tests and theoretical analysis.
Lu Wang
doaj +1 more source
Simulations of aging and plastic deformation in polymer glasses
, 2007 We study the effect of physical aging on the mechanical properties of a model polymer glass using molecular dynamics simulations. The creep compliance is determined simultaneously with the structural relaxation under a constant uniaxial load below yield ...
G. C. Cianci +3 more
core +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Research on Creep Model of Roadway Surrounding Rock Based on Variable Creep Parameters
Meikuang Anquan, 2020 In order to study the creep behavior of surrounding rock of Huaying Coal Mine in Sichuan under different confining pressure characteristics, the triaxial creep test of sandstone was carried out by TAW-2000 test system.
LIU Changming, ZHANG Hong
doaj +1 more source
Bending creep of corrugated fibreboard in cycling relative humidity : a thesis presented in partial fulfilment of the requirements for the degree of Master of Applied Science in Agricultural Engineering at Massey University [PDF]
, 1999 Packaging of fresh fruit for export is a major use for corrugated fibreboard manufactured in New Zealand. However the cold and humid conditions used to preserve fruit quality are particularly detrimental to the strength of corrugated packaging.
McKenzie, Andrew David
core
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Performance and Life Assessment of Reformer Tubes in Petrochemical Industries
High Temperature Materials and Processes, 2014 High temperature mechanical properties of service exposed reformer tubes are compared and revalidated with those of virgin material for the sake of health assessment studies.
Raj A. +5 more
doaj +1 more source