Results 61 to 70 of about 44,930 (304)

New Models for UO2 Fuel Structure Evolution under Irradiation in Fast Reactors

, 2011
On the base of analysis of experimental observations and critical assessment of existing models for oxide fuel structure evolution under operation conditions of fast reactors, new models for fuel restructuring and coring are proposed.
Bourgeois, Brook, Burke, Chubb, Clement, de Halas, Freund, M.S. Veshchunov, Maeda, McEwan, Nichols, Nichols, Ozawa, Ronchi, Sens, Shewmon, Speight, Turnbull, Veshchunov, Veshchunov, Veshchunov, Veshchunov, Yajima, Yanagisawa   +23 more
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Creep characteristics and nonlinear creep damage model of Bocigou formation slate in Kangding-Xinduqiao section of West Sichuan

Shuiwen dizhi gongcheng dizhi, 2023
The creep characteristics of rock are closely related to the long-term stability of rock mass. With the excavation of deep buried tunnels in west China, in order to ensure the safety of engineering and the long-term stability of underground buildings, it
Xiao HE, Shengshan HOU, Xiansen MENG, Liang CHEN, Mingxue LIU, Zhen FENG, Ang LI, Feng JI, Changbao GUO   +8 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Creep damage constitutive model of rock based on the mechanisms of crack-initiated damage and extended damage

Underground Space
Since the classical element model cannot describe the nonlinear characteristics of rock during the entire compressive creep process, nonlinear elements and creep damage are generally introduced in the model to resolve this issue.
Tianbin Li, Chao Chen, Feng Peng, Chunchi Ma, Mou Li, Yixiang Wang   +5 more
doaj   +1 more source

Effect of temperature on aging and time-temperature superposition in nonergodic Laponite suspensions

, 2009
We have studied the effect of temperature on aging dynamics of laponite suspensions by carrying out the rheological oscillatory and creep experiments.
Baghdadi, Cipelletti, Cloitre, Curro, Debenedetti, Fielding, Hodge, Joshi, Joshi, Joshi, Kovacs, Liu, McKenna, O'Connell, Ovarlez, Ren, Shukla, Trappe, Treece, Varun Awasthi, Weitz, Williams, Yogesh M. Joshi   +22 more
core   +1 more source

Accelerated testing of creep in polymeric materials using nanoindentation

Polymer Testing, 2011
Abstract Creep properties of polymers are conventionally obtained from tensile creep tests but, due to the different processing conditions used in their manufacture, the microstructure and properties of the specimens used in this type of test are often different to those found in actual components.
A.S. Maxwell, M.A. Monclus, N.M. Jennett, G. Dean   +3 more
openaire   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

A novel nonlinear creep model based on damage characteristics of mudstone strength parameters.

PLoS ONE, 2021
Mudstone interlayer is a weak layer in rock engineering. When it is subjected to continuous stress higher than its damage threshold, due to the dislocation of particles in mudstone crystals and the expansion of cracks, mudstone strength is gradually ...
Bin Hu, Aneng Cui, Kai Cui, Yang Liu, Jing Li   +4 more
doaj   +1 more source