Results 31 to 40 of about 122,717 (261)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Accelerated Life Test Design for Tractor Powertrain Front Axle
MATEC Web of Conferences, 2016 Accelerated Life Test (ALT) has been applied in the manufacturing for many years due to rapid changing technologies, more complex products, speedier product development, and more demanding customer requirements.
Ismail Azianti, Jung Won, Liu Qiang
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Application of Accelerated Shelf-Life Testing for Determination of Bioactive Emulsion Food Systems’ Shelf Life [PDF]
E3S Web of ConferencesDetermination of the shelf life of food systems involves time consuming and labor-intensive studies. Application of Accelerated Shelf Life Testing (ASLT) allows to determine the degree of time influence and assess environmental conditions’ impact on a ...
Feofilaktova Olga +2 more
doaj +1 more source
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Computation, 2019 Welding alloy 617 with other metals and alloys has been receiving significant attention in the last few years. It is considered to be the benchmark for the development of economical hybrid structures to be used in different engineering applications.
Hafiz Waqar Ahmad +4 more
doaj +1 more source
International Journal of Prognostics and Health Management, 2023 The development of new modes of transportation, such as electric vertical takeoff and landing (eVTOL) aircraft and the use of drones for package and medical delivery, has increased the demand for reliable and powerful electric batteries.
Kajetan Fricke +4 more
doaj +1 more source
FEBS Letters, EarlyView.Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara +3 more
wiley +1 more source
Industria: Jurnal Teknologi dan Manajemen Agroindustri, 2015 Abstrak Penelitian ini bertujuan untuk memperoleh informasi umur simpan dari minuman sari buah sirsak yang dihasilkan unit usaha ABEC berdasarkan kerusakan fisik dan kimia dengan metode Accelerated Shelf Life Testing (ASLT) dengan model persamaan ...
Subarkah Arif +2 more
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