Results 31 to 40 of about 53,047 (263)

Radio Astronomical Tools for the Study of Solar Energetic Particles II.Time-Extended Acceleration at Subrelativistic and Relativistic Energies

Frontiers in Astronomy and Space Sciences, 2021
Solar energetic particle (SEP) events are commonly separated in two categories: numerous “impulsive” events of relatively short duration, and a few “gradual” events, where SEP-intensities may stay enhanced over several days at energies up to several tens
Karl-Ludwig Klein
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

The Crab Pulsar and Nebula as Seen in Gamma-Rays

Universe, 2021
Slightly more than 30 years ago, Whipple detection of the Crab Nebula was the start of Very High Energy gamma-ray astronomy. Since then, gamma-ray observations of this source have continued to provide new surprises and challenges to theories, with the ...
Elena Amato, Barbara Olmi
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

An Introduction to Particle Acceleration in Shearing Flows

Galaxies, 2019
Shear flows are ubiquitously present in space and astrophysical plasmas. This paper highlights the central idea of the non-thermal acceleration of charged particles in shearing flows and reviews some of the recent developments.
Frank M. Rieger
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Analysis of the effect of flow channel structures on the centrifugal accelerated motion of particles in a vacuum state

Scientific Reports
In this study, the impact of flow channel structures on the acceleration of metal particles in a vacuum environment is explored, with the aim of enhancinge the acceleration quality in the centrifugal impact molding of metal powders.
Bo Sun, Shizhong Wei, Peng Li, Han Guo
doaj   +1 more source

Numerical Study of Copper Particle Deposition Process and Residual Stress During Cold Spraying [PDF]

Cailiao Baohu
In order to investigate the acceleration and deformation behavior of particles during cold spraying, the finite element method was used to simulate the acceleration process of copper particles with different sizes inside the Laval spray gun, and the ...
HE Chao, LIU Cansen, SUN Chengchuan, LU Jing, DENG Bixin
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Unlocking the radio- γ spectrum of the pulsar wind nebula around PSR J1124–5916 in SNR G292.0+1.8

Astronomy & Astrophysics
We present the first detection of GeV γ-ray emission potentially associated with the pulsar wind nebula (PWN) hosted by the young core-collapse supernova remnant G292.0+1.8, based on a detailed, time-resolved analysis of Fermi-LAT data.
Lemière A., Castelletti G., Maza N. L.
doaj   +1 more source