Results 41 to 50 of about 53,047 (263)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Particle Acceleration in Relativistic Alfvénic Turbulence

The Astrophysical Journal
Strong magnetically dominated Alfvénic turbulence is an efficient engine of nonthermal particle acceleration in a relativistic collisionless plasma.
Cristian Vega, Stanislav Boldyrev, Vadim Roytershteyn   +2 more
doaj   +1 more source

Microquasar remnants as hidden PeVatrons

Astronomy & Astrophysics
The Large High Altitude Air Shower Observatory (LHAASO) has revealed numerous ultrahigh-energy gamma-ray sources of unknown origin. We propose that a fraction of them can be explained by microquasar remnants, i.e., binary systems where mass transfer has ...
Abaroa Leandro, Romero Gustavo E., Bosch-Ramon Valentí   +2 more
doaj   +1 more source

The energetic storm particle events of 3 November 2021

Frontiers in Astronomy and Space Sciences, 2023
Observations of energetic particles at interplanetary shocks are important to study acceleration mechanisms and their connection with magnetohydrodynamic turbulence.
Federica Chiappetta, Monica Laurenza, Fabio Lepreti, Fabio Lepreti, Simone Benella, Giuseppe Consolini, Maria Federica Marcucci   +6 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

The IXPE and multifrequency polarimetric view of the extreme blazars 1ES 1101-232 and RGB J0710+591

Astronomy & Astrophysics
Multiwavelength polarimetry offers a powerful tool to probe magnetic field and flow geometries in the relativistic jets of blazars. Sources with synchrotron emission that spans a broad frequency range, from radio to X-rays, such as High Synchrotron Peak (
Tavecchio Fabrizio, Kim Dawoon E., Emery Gabriel, Liodakis Ioannis, Agudo Iván, Coppi Paolo, Tagliaferri Giampiero, Di Gesu Laura, Sbarrato Tullia, Ballo Lucia, Sciaccaluga Alberto, Ehlert Steven R., Bonnoli Giacomo, José Aceituno Francisco, Casadio Carolina, Casanova Víctor, Donnarumma Immacolata, Escudero Juan, Morcuende Daniel, Otero-Santos Jorge, Sota Alfredo, Piirola Vilppu, Kouch Pouya M., Lindfors Elina, Nilsson Kari, Myserlis Ioannis, Gurwell Mark, Keating Garrett, Rao Ramprasad, Angelakis Emmanouil, Kraus Alexander, Imazawa Ryo, Sasada Mahito, Fukazawa Yasushi, Kawabata Koji S., Uemura Makoto, Mizuno Tsunefumi, Nakaoka Tatsuya, Tochihara Sumie, Akai Takahiro, Akitaya Hiroshi, Bachev Rumen, Strigachev Anton, Benke Petra, Debbrecht Lena, Eich Julia, Eppel Florian, Gokus Andrea, Hämmerich Steven, Heßdörfer Jonas, Kadler Matthias, Kim Sanghyun, Kirchner Dana, Paraschos Georgios Filippos, Rösch Florian, Schulga Wladislaw   +55 more
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source