Results 121 to 130 of about 370,968 (321)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Highly uniform silicon nanopatterning with deep-ultraviolet femtosecond pulses

Nanophotonics
The prospect of employing nanophotonic methods for controlling photon–electron interactions has ignited substantial interest within the particle accelerator community.
Granados Eduardo, Martinez-Calderon Miguel, Groussin Baptiste, Colombier Jean Philippe, Santiago Ibon   +4 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Probing the Top Quark Flavour-Changing Neutral Current at a Future Electron-Positron Collider

Advances in High Energy Physics, 2014
We present a study to examine the sensitivity of a future e-e+ collider to the anomalous top flavour-changing neutral current (FCNC) to the gluon. To separate signal from background a multivariate analysis is performed on top quark pair and background ...
Hoda Hesari, Hamzeh Khanpour, Morteza Khatiri Yanehsari, Mojtaba Mohammadi Najafabadi   +3 more
doaj   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Applications of the Strategic Defense Initiative's compact accelerators [PDF]

The Strategic Defense Initiative's (SDI) investment in particle accelerator technology for its directed energy weapons program has produced breakthroughs in the size and power of new accelerators.
Lynch, Ted, Montanarelli, Nick
core   +1 more source

Possible Accelerators @ CERN Beyond the LHC [PDF]

, 1999
The physics and world-wide accelerator context for possible accelerator projects at CERN after the LHC are reviewed, including the expectation that an e+ e- linear collider in the TeV energy range will be built elsewhere.
Ellis, John
core   +1 more source

The accelerated acceleration of the universe

Journal of Cosmology and Astroparticle Physics, 2006
We present a simple mechanism which can mimic dark energy with an equation of state w < -1 as deduced from the supernova data. We imagine that the universe is accelerating under the control of a quintessence field, which is moving up a very gently sloping potential.
Csaki, Csaba, Kaloper, Nemanja, Terning, John   +2 more
openaire   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Business incubators and accelerators: a co-citation analysis-based, systematic literature review

Journal of Technology Transfer, 2017
A long and rich research tradition exists on the phenomenon of business incubators since this kind of venture support institution first emerged. One can observe an increasing heterogeneity of incubation beyond the traditional mainstream focus on regional
J. Hausberg, Sabrina Korreck
semanticscholar   +1 more source