Results 111 to 120 of about 10,763,224 (335)

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

open access: yesMolecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani   +14 more
wiley   +1 more source

Lack of information and access to advanced treatment for Parkinson’s disease patients

open access: yesJournal of Multidisciplinary Healthcare, 2011
J Lökk1,21Department of Neurobiology, Caring Sciences and Society, The Karolinska Institute, 2Karolinska University Hospital Huddinge, Stockholm, SwedenBackground: Parkinson’s disease (PD) patients’ own knowledge and ...
Lökk J
doaj  

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

open access: yesMolecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez   +17 more
wiley   +1 more source

Expression and DNA methylation of 20S proteasome subunits as prognostic and resistance markers in cancer

open access: yesMolecular Oncology, EarlyView.
Comprehensive analysis of genomic mutations, gene expression, DNA methylation, and pathway analysis of TCGA data was carried out to define cancer types in which proteasome subunits expression is associated with worse survival. Albeit the effect of specific proteasome subunits on cellular function, the main role of the proteasome is better evaluated ...
Ruba Al‐Abdulla   +5 more
wiley   +1 more source

Collaborative Research in e-Science and Open Access to Information [PDF]

open access: yes
This contribution examines various aspects of “openness” in research, and seeks to gauge the degree to which contemporary “e-science” practices are congruent with “open science.” Norms and practices of openness are vital for the work of modern scientific
Matthijs den Besten   +2 more
core  

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