Results 91 to 100 of about 94,242,737 (296)

Evaluation of an Access-Risk-Knowledge (ARK) Platform for Governance of Risk and Change in Complex Socio-Technical Systems. [PDF]

open access: yesInt J Environ Res Public Health, 2021
McDonald N   +14 more
europepmc   +1 more source

The impact of open access initiative on knowledge sharing [PDF]

open access: yes, 2012
The main focus of this paper is to look at the role of the open access initiative (OAI) as a channel for knowledge sharing that could be used for the disseminate knowledge and research funding.
Adni, Rhiza
core  

Translating whole‐genome doubling into precision medicine in cancer

open access: yesMolecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Copyright and Access to Knowledge (A2K)

open access: yes, 2009
PowerPoint presentationAccess to knowledge (A2K) is essential to an equitable (information) society. ICTs have the potential to greatly increase A2K and to enhance creation of new knowledge, innovation and creativity.
Kawooya, Dick, Armstrong, Chris
core   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

open access: yesMolecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Reducing the Treatment Gap and Public Health Burden of Osteoporotic Fractures [PDF]

open access: yes, 2021
K2P Policy Briefs bring together global research evidence, local evidence and context-specific knowledge to inform deliberations about health policies and programmes.
Hilal, Nadeen   +4 more
core  

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

open access: yesMolecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche   +10 more
wiley   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

open access: yesMolecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou   +4 more
wiley   +1 more source

Degree of Access, and Terms & Conditions of Access [PDF]

open access: yes, 2000
Access Subgroup report by the Advisory Committee on Online Access and Security regarding their findings on the amount of access to personal data that consumers should have from websites that gather ...
Advisory Committee on Online Access and Security: Access Subgroup One
core  

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