Results 71 to 80 of about 71,112 (230)

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

Accessory DNA in the Genomes of Representatives of the Escherichia coli Reference Collection [PDF]

Journal of Bacteriology, 1999
ABSTRACT Different strains of the Escherichia coli reference collection (ECOR) differ widely in chromosomal size. To analyze the nature of the differential gene pool carried by different strains, we have followed an approach in which random amplified polymorphic DNA (RAPD) was used to generate several PCR ...
A, Hurtado, F, Rodríguez-Valera
openaire   +2 more sources

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Coordinated regulation of core and accessory genes in the multipartite genome of Sinorhizobium fredii [PDF]

PLOS Genetics, 2018
Prokaryotes benefit from having accessory genes, but it is unclear how accessory genes can be linked with the core regulatory network when developing adaptations to new niches. Here we determined hierarchical core/accessory subsets in the multipartite pangenome (composed of genes from the chromosome, chromid and plasmids) of the soybean microsymbiont ...
Jian Jiao, Meng Ni, Biliang Zhang, Ziding Zhang, J. Peter W. Young, Ting-Fung Chan, Wen Xin Chen, Hon-Ming Lam, Chang Fu Tian   +8 more
openaire   +5 more sources

Global Genomic Landscapes of Lactiplantibacillus plantarum: Universal GABA Biosynthetic Capacity with Strain-Level Functional Diversity

Life
Lactiplantibacillus plantarum is widely used in fermented foods and as a probiotic, yet the genomic basis underlying its γ-aminobutyric acid (GABA) production capacity and strain-level functional diversity remains incompletely resolved.
Monwadee Wonglapsuwan, Thitima Ninrat, Nattarika Chaichana, Thitaporn Dechathai, Sirikan Suwannasin, Kamonnut Singkhamanan, Rattanaruji Pomwised, Komwit Surachat   +7 more
doaj   +1 more source

Pseudomonas aeruginosa genomic structure and diversity

Frontiers in Cellular and Infection Microbiology, 2011
The Pseudomonas aeruginosa genome (G + C content 65-67%, size 5.5 – 7 Mbp) is made up of a single circular chromosome and a variable number of plasmids. Sequencing of complete genomes or blocks of the accessory genome has revealed that the genome encodes
Jens eKlockgether, Nina eCramer, Lutz eWiehlmann, Colin F. Davenport, Burkhard eTümmler   +4 more
doaj   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

Genome-Wide Association Study of Accessory Atrioventricular Pathways

JAMA Cardiology
ImportanceUnderstanding of the genetics of accessory atrioventricular pathways (APs) and affiliated arrhythmias is limited.ObjectiveTo investigate the genetics of APs and affiliated arrhythmias.Design, Setting, and ParticipantsThis was a genome-wide association study (GWAS) of APs, defined by International Classification of Diseases (ICD) codes and/or ...
Hildur M. Aegisdottir, Laura Andreasen, Rosa B. Thorolfsdottir, Gardar Sveinbjornsson, Andrea B. Jonsdottir, Lilja Stefansdottir, Gudmar Thorleifsson, Asgeir Sigurdsson, Gisli H. Halldorsson, Julien Barc, Floriane Simonet, Vinicius Tragante, Asmundur Oddsson, Egil Ferkingstad, Jesper Hastrup Svendsen, Jonas Ghouse, Gustav Ahlberg, Christian Paludan-Müller, Katra Hadji-Turdeghal, Mariana Bustamante, Magnus O. Ulfarsson, Anna Helgadottir, Solveig Gretarsdottir, Saedis Saevarsdottir, Ingileif Jonsdottir, Christian Erikstrup, Henrik Ullum, Erik Sørensen, Søren Brunak, Christian Jøns, Chaoqun Zheng, Connie R. Bezzina, Kirk U. Knowlton, Lincoln D. Nadauld, Patrick Sulem, Sisse R. Ostrowski, Ole B. Pedersen, David O. Arnar, Daniel F. Gudbjartsson, Morten S. Olesen, Henning Bundgaard, Hilma Holm, Kari Stefansson, Karina Banasik, Jakob Bay, Jens K. Boldsen, Thorsten Brodersen, Søren Brunak, Alfonso Buil Demur, Lea A. N. Christoffersen, Maria Didriksen, Khoa M. Dinh, Joseph Dowsett, Christian Erikstrup, Bjarke Feenstra, Frank Geller, Daniel Gudbjartsson, Thomas F. Hansen, Dorte Helenius Mikkelsen, Lotte Hindhede, Henrik Hjalgrim, Jakob H. V. Stemann, Bitten A. Jensen, Andrew Joseph Schork, Katrine Kaspersen, Bertram D. Kjerulff, Mette Kongstad, Susan Mikkelsen, Christina Mikkelsen, Ioanna Nissen, Mette Nyegaard, Sisse R. Ostrowski, Ole B. Pedersen, Liam J. E. Quinn, Þórunn Rafnar, Palle D. Rohde, Klaus Rostgaard, Michael Schwinn, Kari Stefansson, Hreinn Stefánsson, Erik Sørensen, Unnur Thorsteinsdóttir, Lise W. Thørner, Mie Topholm Bruun, Henrik Ullum, Thomas Werge, David Westergaard   +86 more
openaire   +4 more sources

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source

A Genome-Based Model to Predict the Virulence of Pseudomonas aeruginosa Isolates

mBio, 2020
Variation in the genome of Pseudomonas aeruginosa, an important pathogen, can have dramatic impacts on the bacterium’s ability to cause disease. We therefore asked whether it was possible to predict the virulence of P.
Nathan B. Pincus, Egon A. Ozer, Jonathan P. Allen, Marcus Nguyen, James J. Davis, Deborah R. Winter, Chih-Hsien Chuang, Cheng-Hsun Chiu, Laura Zamorano, Antonio Oliver, Alan R. Hauser   +10 more
doaj   +1 more source