Results 111 to 120 of about 305,897 (326)
PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source
Temporal (1948–2012) and Dynamic Evolution of the Wouri Estuary Coastline within the Gulf of Guinea
Journal of Marine Science and Engineering, 2019 The Wouri estuary is located in the Gulf of Guinea on the Atlantic coast of Cameroon’s coastline plain (3°49′ and 4°04′ north latitude and 9°20′ to 9°40′ east longitude), and is strongly influenced by ...
Yannick Fossi Fotsi +4 more
doaj +1 more source
, 2022 48 pages, 6 figures, Invited (and accepted) chapter for the Handbook of X-ray and Gamma-ray Astrophysics, Editors: Cosimo Bambi, Andrea ...
openaire +2 more sources
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Study Channel Changes and Bank Erosion in the Gamasiab River from 1958 to 2010 [PDF]
نشریه جغرافیا و برنامهریزی, 2014 River channel change, such as bank erosion and accretion are natural processes in alluvial rivers. This paper aims to investigate migration and channel change plan form and effect on bank erosion and accretion done in Gamasiab River in Kermanshah ...
Mohammadhossein Rezaei Moghadam +1 more
doaj
Dynamics of Small-Scale Topographic Heterogeneity in European Sandy Salt Marshes
Journal of Marine Science and Engineering, 2016 Heterogeneity can boost biodiversity, as well as increase the resilience of an ecosystem to changing environmental conditions; therefore, it is important to understand how topographic heterogeneity in ecosystems is formed.
Kelly Elschot, Jan P. Bakker
doaj +1 more source
Molecular Oncology, EarlyView.A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira +14 more
wiley +1 more source
Polarization properties of thermal accretion disk emission
Astronomy & AstrophysicsThe X-ray polarimetric observing window reopening is shedding new light on our current understanding of compact accreting sources. This is particularly true for stellar-mass black hole sources observed in the thermally dominated state, for which the ...
Marra L. +6 more
doaj +1 more source
Episodic accretion, protostellar radiative feedback, and their role in low-mass star formation
, 2012 Protostars grow in mass by accreting material through their discs, and this accretion is initially their main source of luminosity. The resulting radiative feedback heats the environments of young protostars, and may thereby suppress further ...
Hubber, David A. +2 more
core +1 more source
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source