Results 111 to 120 of about 306,823 (323)

Accretion in giant planet circumplanetary disks

, 2014
During the final growth phase of giant planets, accretion is thought to be controlled by a surrounding circumplanetary disk. Current astrophysical accretion disk models rely on hydromagnetic turbulence or gravitoturbulence as the source of effective ...
Keith, Sarah L., Wardle, Mark
core   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Spectral and Temporal Properties of CXOUJ122956.7+075728 (ULX-1), an Ultraluminous X-Ray Source in NGC 4472

East European Journal of Physics
This report presents a comprehensive analysis of the spectral and temporal characteristics of a highly significant Ultraluminous X-ray Source (ULX) designated as CXOUJ122956.7+075728 (ULX-1) situated in the elliptical galaxy NGC 4472 within the Virgo ...
A. Senorita Devi
doaj   +1 more source

The Cooling Flow to Accretion Flow Transition

, 1999
Cooling flows in galaxy clusters and isolated elliptical galaxies are a source of mass for fueling accretion onto a central supermassive black hole. We calculate the dynamics of accreting matter in the combined gravitational potential of a host galaxy ...
Bailey M. E., Eliot Quataert, Fabian A. C., Kormendy J., Matthews W. G., Paczynski B., Ramesh Narayan, Shakura N. I.   +7 more
core   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Evolution of the Shoreline Between the Ports of Valencia and Sagunto, Spain (1957–2024)

Journal of Marine Science and Engineering
Coastal areas are increasingly affected by erosion due to climate change and human interventions, threatening the stability of many shorelines. Understanding coastal dynamics is therefore crucial for developing effective conservation and management ...
Joan Ortiz Vivas, Ana María Blázquez Morilla, Borja Martínez-Clavel Valles   +2 more
doaj   +1 more source

Accretion within the innermost stable circular orbit: analytical thermodynamic solutions in the adiabatic limit [PDF]

, 2023
Andrew Mummery, Steven A. Balbus
openalex   +1 more source

Bondi-Hoyle-Lyttleton Accretion onto a Protoplanetary Disk

, 2009
Young stellar systems orbiting in the potential of their birth cluster can accrete from the dense molecular interstellar medium during the period between the star's birth and the dispersal of the cluster's gas. Over this time, which may span several Myr,
Adams, Balog, Bate, Beck, Binney, Bisnovatyi-Kogan, Bondi, Bondi, Bonnell, Boss, Chevalier, Clarke, Currie, Currie, Edgar, Hartigan, Henry B. Throop, Hillenbrand, Hines, Johnstone, Krumholz, Krumholz, Laughlin, Malmberg, Mann, Matsumura, Mezger, Moeckel, Mori, Nickolas Moeckel, Rice, Ruffert, Ruffert, Ruffert, Ruffert, Ruffert, Shima, Smith, Thommes, Throop, Throop, Ward-Thompson, Weidenschilling, Zakamska   +43 more
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

The relationship between the emission line, continuum luminosity, and Baldwin effect in blazars

Astronomy & Astrophysics
Aims. This study investigates the relationship between the Mg II λ2798 Å emission line and the 3000 Å continuum luminosity, as well as the Baldwin effect, in a sample of 40’,685 radio-quiet (RQ) quasars and 441 flat spectrum radio quasars (FSRQs ...
Patiño-Álvarez Víctor M., Guerrero-González Jonhatan U., Chavushyan Vahram, Monjardin-Ward Douglas E., Arshakian Tigran G., Cruz-González Irene   +5 more
doaj   +1 more source