Results 81 to 90 of about 1,349,968 (301)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Tooth Shape Research and Contour Machining of Hirth Coupling
Jixie chuandong, 2015 The hirth coupling is widely used in the centrifugal air compressor unit due to its characteristic of high torque capacity and self centering etc.It is aimed at deriving the accurate calculating formulas of hirth tooth shape,to provide accurate ...
Shao Guangjun, Li Gang, Ruan Wenhao
doaj
Integrating Optical Draw-In Measurements with Finite Element Analysis for Enhanced Process Insights in Sheet Metal Forming [PDF]
MATEC Web of ConferencesAccurate monitoring of draw-in behaviour during sheet metal forming is crucial for understanding material flow, optimizing process parameters, and validating finite element (FE) simulations.
Chezan Toni +4 more
doaj +1 more source
An Accurate Closed-Form Approximation of the Distributed MIMO Outage Probability
IEEE Transactions on Wireless Communications, 2011 The mutual information (MI) of multiple-input multiple-output (MIMO) system over Rayleigh fading channel is known to asymptotically follow a normal probability distribution. In this paper, we first prove that the MI of distributed MIMO (DMIMO) system is also asymptotically equivalent to a Gaussian random variable (RV) by deriving its moment generating ...
Fabien Héliot +2 more
openaire +4 more sources
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
A new micro scale FE model of crystalline materials in micro forming process
MATEC Web of Conferences, 2016 Micro forming of metals has drawn global attention due to the increasing requirement of micro metal products. However, the size effects become significant in micro forming processes and affect the application of finite element (FE) simulation of micro ...
Luo Liang +5 more
doaj +1 more source
A non-invasive node-based form finding approach with discretization-independent target configuration
Advanced Modeling and Simulation in Engineering Sciences, 2018 Form finding is used to optimize the shape of a semi-finished product, i.e. the material configuration in a forming process. The geometry of the semi-finished product is adapted so that the computed spatial configuration corresponds to a prescribed ...
Michael Caspari +2 more
doaj +1 more source
On the free volume in nuclear multifragmentation [PDF]
, 2000 In many statistical multifragmentation models the volume available to the $N$ nonoverlapping fragments forming a given partition is a basic ingredient serving to the simplification of the density of states formula. One therefore needs accurate techniques
Al.H. Raduta +15 more
core +2 more sources
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Metals, 2020 Incremental sheet forming (ISF) is a flexible sheet metal forming process to realize products within short time from design to the first produced part. Although fundamental research on ISF has been carried out around the world, ISF still misses commonly ...
Roman Ulrich Christopher Schmitz +3 more
doaj +1 more source