Results 101 to 110 of about 149,286 (348)

The role of fibroblast growth factors in cell and cancer metabolism

FEBS Letters, EarlyView.
Fibroblast growth factor (FGF) signaling regulates crucial signaling cascades that promote cell proliferation, survival, and metabolism. Therefore, FGFs and their receptors are often dysregulated in human diseases, including cancer, to sustain proliferation and rewire metabolism.
Jessica Price, Chiara Francavilla
wiley   +1 more source

The Saccharomyces cerevisiae Mob2p-Cbk1p kinase complex promotes polarized growth and acts with the mitotic exit network to facilitate daughter cell-specific localization of Ace2p transcription factor. [PDF]

, 2002
The Saccharomyces cerevisiae mitotic exit network (MEN) is a conserved signaling network that coordinates events associated with the M to G1 transition. We investigated the function of two S.
Drubin, David G, Kurischko, Cornelia, Luca, Francis C, Shokat, Kevan, Weiss, Eric L, Zhang, Chao   +5 more
core   +2 more sources

Composition and divergence of coronavirus spike proteins and host ACE2 receptors predict potential intermediate hosts of SARS‐CoV‐2

Journal of Medical Virology, 2020
From the beginning of 2002 and 2012, severe respiratory syndrome coronavirus (SARS‐CoV) and Middle East respiratory syndrome coronavirus (MERS‐CoV) crossed the species barriers to infect humans, causing thousands of infections and hundreds of deaths ...
Zhixin Liu, Xiao Xiao, Xiuli Wei, Jian Li, Jing Yang, Huabing Tan, Jianyong Zhu, Qiwei Zhang, Jianguo Wu, Long Liu   +9 more
semanticscholar   +1 more source

SARS-CoV-2 Omicron RBD shows weaker binding affinity than the currently dominant Delta variant to human ACE2

Signal Transduction and Targeted Therapy, 2022
Dear Editor, SARS-coronavirus-2 (SARS-CoV-2) Omicron variant (B.1.1.529) is of great concern to the world due to its multiple mutations that may have an impact on transmissibility and immune evasion.
Leyun Wu, Liping Zhou, Mengxia Mo, Tingting Liu, Chengkun Wu, Chunye Gong, Kai Lu, Likun Gong, Weiliang Zhu, Zhijian Xu   +9 more
semanticscholar   +1 more source

P-030 ACE2 receptor and its isoform short-ACE2 are expressed on human spermatozoa

Human Reproduction, 2022
Abstract Study question Do human spermatozoa express angiotensin-converting enzyme 2 (ACE2) receptor? What would be its localization? Summary answer Human spermatozoa express uniformly ACE2 on the sperm head and the flagellum ...
Ramal Sanchez, M, Castellini, C, Cimini, C, Taraschi, A, Valbonetti, L, Barbonetti, A, Bernabo, Nicola, Barboni, B   +7 more
openaire   +2 more sources

Nano‐ and Micro‐Sized Solid Materials Used as Antiviral Agents

Advanced Functional Materials, EarlyView.
Due to the rise of viral infections in humans and possible viral outbreaks, the use of nano‐ or micro‐sized materials as antiviral agents is rapidly increasing. This review explores their antiviral properties against RNA and DNA viruses, either as a prevention or a treatment tool, by delving into their mechanisms of action and how to properly assess ...
Orfeas‐Evangelos Plastiras, Imelda Raczkiewicz, Peggy Bouquet, Jean‐Philippe Dacquin, Jeremy Dhainaut, Anne Goffard, Christophe Volkringer   +6 more
wiley   +1 more source

SARS-CoV-2 binds platelet ACE2 to enhance thrombosis in COVID-19

Journal of Hematology & Oncology, 2020
Background Critically ill patients diagnosed with COVID-19 may develop a pro-thrombotic state that places them at a dramatically increased lethal risk. Although platelet activation is critical for thrombosis and is responsible for the thrombotic events ...
Shenmin Zhang, Yangyang Liu, Xiaofang Wang, Li Yang, Haishan Li, Yuyan Wang, Mengduan Liu, Xiaoyan Zhao, Youhua Xie, Yan Yang, Shenghui Zhang, Zhichao Fan, Jianzeng Dong, Zhenghong Yuan, Z. Ding, Yi Zhang, Liang Hu   +16 more
semanticscholar   +1 more source

FXR inhibition may protect from SARS-CoV-2 infection by reducing ACE2

Nature, 2022
Preventing SARS-CoV-2 infection by modulating viral host receptors, such as angiotensin-converting enzyme 2 (ACE2)^ 1 , could represent a new chemoprophylactic approach for COVID-19 that complements vaccination^ 2 , 3 .
T. Brevini, Mailis Maes, G. Webb, Binu V. John, C. Fuchs, G. Buescher, Lu Wang, C. Griffiths, Marnie L Brown, W. Scott, Pehuén Pereyra-Gerber, W. Gelson, S. Brown, Scott Dillon, D. Muraro, Joanne Sharp, M. Neary, H. Box, Lee M. Tatham, James P. Stewart, P. Curley, H. Pertinez, S. Forrest, P. Mlcochova, Sagar S. Varankar, M. Darvish-Damavandi, Victoria L. Mulcahy, R. Kuc, Thomas L. Williams, James A. Heslop, D. Rossetti, Olivia C. Tysoe, Vasileios Galanakis, Marta Vilà-González, Thomas W M Crozier, Johannes Bargehr, S. Sinha, S. Upponi, C. Fear, L. Swift, K. Saeb‐Parsy, S. Davies, A. Wester, H. Hagström, E. Melum, D. Clements, Peter Humphreys, Joanne Herriott, Edyta Kijak, H. Cox, Chloe Bramwell, A. Valentijn, Christopher J. R. Illingworth, B. Dahman, Dustin Bastaich, Raphaella D. Ferreira, Thomas Marjot, Eleanor Barnes, A. Moon, A. Barritt, Ravindra K. Gupta, S. Baker, A. Davenport, G. Corbett, V. Gorgoulis, S. J. Buczacki, J. Lee, N. Matheson, M. Trauner, A. Fisher, Paul Gibbs, A. Butler, C. Watson, G. Mells, G. Dougan, A. Owen, A. Lohse, L. Vallier, F. Sampaziotis   +78 more
semanticscholar   +1 more source

Multivalent Protein Nanorings for Broad and Potent SARS‐CoV‐2 Neutralization

Advanced Healthcare Materials, EarlyView.
A protein‐only, modular multivalent nanoscaffold displaying 20 anchor points, decorated with two different binders (10 of each), targeting the SARS‐CoV‐2 receptor‐binding domain is presented. The construct self‐assembles into stable, biocompatible, homogeneous nanoparticles, exhibit synergistic binding with fM IC50 values. It also detects spike at 9 ng 
Molood Behbahanipour, Carla Goldin, Cecilia Arahi Prato, Ana Luz Paletta, Oriol Bárcenas, Susanna Navarro, Jordi Pujols, Daniel H. Murgida, María Virginia Tribulatti, Sebastián Esperante, Damian Alvarez‐Paggi, Salvador Ventura   +11 more
wiley   +1 more source

COVID-19 clinical presentations: the modern mimic of other conditions

South Sudan Medical Journal, 2021
The coronavirus pandemic (COVID-19) has placed enormous challenges on the health sector. Diagnosis is one of these challenges, where a clinical presentation may suggest a disease other than COVID-19.
Mohamed Eltayieb Elawad, Abrar Bakry Elmalik, Doaa Mohamed Ahmed Hassan, Fatima Salaheldin Ibrahim Mohammed, Onaisa Hassan Kabroun Idris, Nasreen Sulaiman Omar Abdulaziz, Ibrahim A Ali   +6 more
doaj