Results 101 to 110 of about 77,670 (298)

Interaction of Asparagusic Acid, Asparaptines and Related Dithiolane Derivatives With Angiotensin-Converting Enzyme-2 (ACE-2): A Molecular Docking Study. [PDF]

J Biochem Mol Toxicol
The binding of asparagusic acid and asparaptines, isolated from asparagus, to the angiotensin‐converting enzyme 2 (ACE2) has been analyzed using molecular docking. The testing of related products with a dithiolane motif led to the identification of the drug candidate CMX‐2043 as a potent ACE2 binder.
Vergoten G, Bailly C.
europepmc   +2 more sources

Sensor‐Embedded Muscle for Closed‐Loop Controllable Actuation in Proprioceptive Biohybrid Robots

Advanced Intelligent Systems, EarlyView.
Skeletal muscle tissue‐based bioactuators move in response to externally applied electrical stimuli in open‐loop control, which lacks knowledge of the actuator's state. Herein, a soft and fiber‐shaped piezoresistive mechanosensor that integrates with the soft tissue and operates in the cell culture environment is used to create the first proprioceptive
Miriam Filippi, Aiste Balciunaite, Antonia Georgopoulou, Pablo Paniagua, Felix Drescher, Minghao Nie, Shoji Takeuchi, Frank Clemens, Robert K. Katzschmann   +8 more
wiley   +1 more source

The association of chronic liver disorders with exacerbation of symptoms and complications related to COVID‐19: A systematic review and meta‐analysis of cohort studies

The Clinical Respiratory Journal, Volume 16, Issue 12, Page 777-792, December 2022., 2022
The risk of death in COVID‐19 patients with chronic liver disorders was higher than in ones without the chronic liver disease (RR: 1.52; CI 95%: 1.46–1.57; I2: 86.14%). Abstract Introduction The aim of this review was to combine the results of published cohort studies to determine the exact association between chronic liver disorders, and the severe ...
Maryam Afraie, Pardis Mohammadzedeh, Mobin Azami, Sorour Khateri, Kamran Zamani, Farhad Moradpour, Yousef Moradi   +6 more
wiley   +1 more source

ACE2 diversity in placental mammals reveals the evolutionary strategy of SARS-CoV-2

Genetics and Molecular Biology
The recent emergence of SARS-CoV-2 is responsible for the current pandemic of COVID-19, which uses the human membrane protein ACE2 as a gateway to host-cell infection. We performed a comparative genomic analysis of 70 ACE2 placental mammal orthologues to
Bibiana S.O. Fam, Pedro Vargas-Pinilla, Carlos Eduardo G. Amorim, Vinicius A. Sortica, Maria Cátira Bortolini   +4 more
doaj   +1 more source

COVID-19 Induced Cytokine Storm and the Impact of Obesity and Vitamin D Deficiency [PDF]

Journal of Krishna Institute of Medical Sciences University, 2021
Recent studies on Coronavirus Disease 2019 (COVID-19) have shown that obesity and vitamin D deficiency increase the risk of Severe Acute Respiratory Syndrome Coronavirus 2 (SARSCoV-2) infection and its complications. The levels of cytokines are increased
Shobha Chikkavaddaragudi Ramachandra, Akila Prashant, Prashant Vishwanath   +2 more
doaj  

Sitagliptin: a potential drug for the treatment of COVID-19?

Acta Pharmaceutica, 2021
Recently, an outbreak of a fatal coronavirus, SARS-CoV-2, has emerged from China and is rapidly spreading worldwide. Possible interaction of SARS-CoV-2 with DPP4 peptidase may partly contribute to the viral pathogenesis.
Bardaweel Sanaa K., Hajjo Rima, Sabbah Dima A.   +2 more
doaj   +1 more source

Mapping active allosteric loci SARS-CoV Spike Proteins by means of Protein Contact Networks [PDF]

arXiv, 2020
Coronaviruses are a class of virus responsible of the recent outbreak of Human Severe Acute Respiratory Syndrome. The molecular machinery behind the viral entry and thus infectivity is based on the formation of the complex of virus spike protein with the angiotensin-converting enzyme 2 (ACE2).
arxiv  

The emerging role of ACE2 in physiology and disease [PDF]

The Journal of Pathology, 2007
AbstractThe renin–angiotensin–aldosterone system (RAAS) is a key regulator of systemic blood pressure and renal function and a key player in renal and cardiovascular disease. However, its (patho)physiological roles and its architecture are more complex than initially anticipated.
Inge Hamming, Ron Korstanje, Wim Timens, A J Turner, Gerarda Navis, Bart L. Haagmans, A.D.M.E. Osterhaus, van Harry Goor, Nigel M. Hooper, M. E. Cooper   +9 more
openaire   +4 more sources

Big data and machine learning to tackle diabetes management

European Journal of Clinical Investigation, Volume 53, Issue 1, January 2023., 2023
Abstract Background Type 2 Diabetes (T2D) diagnosis is based solely on glycaemia, even though it is an endpoint of numerous dysmetabolic pathways. Type 2 Diabetes complexity is challenging in a real‐world scenario; thus, dissecting T2D heterogeneity is a priority. Cluster analysis, which identifies natural clusters within multidimensional data based on
Ana F. Pina, Maria João Meneses, Inês Sousa‐Lima, Roberto Henriques, João F. Raposo, Maria Paula Macedo   +5 more
wiley   +1 more source

P-030 ACE2 receptor and its isoform short-ACE2 are expressed on human spermatozoa

Human Reproduction, 2022
Abstract Study question Do human spermatozoa express angiotensin-converting enzyme 2 (ACE2) receptor? What would be its localization? Summary answer Human spermatozoa express uniformly ACE2 on the sperm head and the flagellum ...
Ramal Sanchez, M, Castellini, C, Cimini, C, Taraschi, A, Valbonetti, L, Barbonetti, A, Bernabo, Nicola, Barboni, B   +7 more
openaire   +2 more sources