Results 111 to 120 of about 149,286 (348)
SARS CoV subunit vaccine: Antibodymediated neutralisation and enhancement [PDF]
, 2012 1. A SARS vaccine was produced based on recombinant native full-length Spike-protein trimers (triSpike) and efficient establishment of a vaccination procedure in rodents. 2.
Altmeyer, R +14 more
core +1 more source
Pathological Ace2-to-Ace enzyme switch in the stressed heart is transcriptionally controlled by the endothelial Brg1–FoxM1 complex [PDF]
, 2016 Genes encoding angiotensin-converting enzymes (Ace and Ace2) are essential for heart function regulation. Cardiac stress enhances Ace, but suppresses Ace2, expression in the heart, leading to a net production of angiotensin II that promotes cardiac ...
Chang, Ching-Pin +9 more
core +1 more source
The Spatial and Cell-Type Distribution of SARS-CoV-2 Receptor ACE2 in the Human and Mouse Brains
bioRxiv, 2020 By engaging angiotensin-converting enzyme 2 (ACE2 or Ace2), the novel pathogenic SARS-coronavirus 2 (SARS-CoV-2) may invade host cells in many organs, including the brain. However, the distribution of ACE2 in the brain is still obscure.
Rongrong Chen +7 more
semanticscholar +1 more source
ACE2 in the renin–angiotensin system
Clinical Science, 2020 AbstractIn 2020 we are celebrating the 20th anniversary of the angiotensin-converting enzyme 2 (ACE2) discovery. This event was a landmark that shaped the way that we see the renin–angiotensin system (RAS) today. ACE2 is an important molecular hub that connects the RAS classical arm, formed mainly by the octapeptide angiotensin II (Ang II) and its ...
Verano-Braga, Thiago +4 more
openaire +2 more sources
Advanced Science, EarlyView.A novel amino acid (aa)‐score‐based single‐position peptide clustering strategy is developed for peptidomics, enabling precise profiling of protein proteolysis in plasma from β‐thalassemia cohort. The method identifies new aa position‐based peptide cluster biomarkers validated by heavy‐labeled peptides, visualizes aggregated changes, uncovers disease ...
Na Li +13 more
wiley +1 more source
Insights into the COVID-19 pandemic: Origin, pathogenesis, diagnosis, and therapeutic interventions
Frontiers in Bioscience-Elite, 2020 Coronavirus disease (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a member of the human coronavirus (HCoV) family that targets the lower part of the respiratory tract and causes severe acute respiratory syndrome ...
Mahmoud M. Berekaa
doaj +1 more source
Juvenis Scientia, 2021 In recent months it has emerged that the novel coronavirus — responsible for the COVID-19 pandemic — causes reduction of smell and taste in a large fraction of patients.
R. Butowt, C. S. von Bartheld
doaj +1 more source
The effect of chronic peripheral nesfatin-1 application on blood pressure in normal and chronic restraint stressed rats: Related with circulating level of blood pressure regulators [PDF]
, 2015 Nesfatin is a peptide secreted by peripheral tissues, central and peripheral nervous system. It is involved in the regulation of homeostasis. Although the effects of nesfatin-1 on nutrition have been studied widely in the literature, the mechanisms of ...
Ayada, C. +3 more
core +1 more source
Is Low Alveolar Type II Cell SOD3 in the Lungs of Elderly Linked to the Observed Severity of COVID-19? [PDF]
, 2020 Human lungs single cell RNA sequencing data from healthy donors (elderly and young; GEO accession number GSE122960) were analyzed to isolate and specifically study gene expression in alveolar type II cells.
Abouhashem, Ahmed S. +3 more
core +1 more source
Cellular & Molecular Immunology, 2020 Coronavirus disease 2019 (COVID-19), caused by the novel human coronavirus SARS-CoV-2, is currently a major threat to public health worldwide. The viral spike protein binds the host receptor angiotensin-converting enzyme 2 (ACE2) via the receptor-binding
C. Yi +14 more
semanticscholar +1 more source