Results 31 to 40 of about 77,670 (298)
Inhibition of ACE2‐Spike Interaction by an ACE2 Binder Suppresses SARS‐CoV‐2 Entry [PDF]
Angewandte Chemie International Edition, 2022 AbstractThe emergence of SARS‐CoV‐2 variants is a significant concern in developing effective therapeutics and vaccines in the middle of the ongoing COVID‐19 pandemic. Here, we have identified a novel small molecule that inhibited the interactions between SARS‐CoV‐2 spike RBDs and ACE2 by modulating ACE2 without impairing its enzymatic activity ...
Young‐Hee Shin +7 more
openaire +2 more sources
European Journal of Immunology, Volume 52, Issue 12, Page 1972-1979, December 2022., 2022 To investigate atopic immune reactions in response to SARS‐CoV‐2 mRNA vaccinations or mild infections serum IgE and cytokines were analyzed. An atopic environment prone to reactions against aeroallergens was revealed in convalescents but not vaccinated.
Stefan Meltendorf +13 more
wiley +1 more source
Glucose metabolism disorders associated with COVID-19: clinical and morphological study
Сахарный диабет, 2023 BACKGROUND. Glucose metabolism disorders (GMD) were detected both in acute and in post-COVID, however, its pathogenic aspects remain unclear.AIM. To analyze the occurrence of GMD in post-COVID patients who have had moderate and severe COVID-19 without ...
T. L. Karonova +10 more
doaj +1 more source
European Journal of Immunology, Volume 53, Issue 1, January 2023., 2023 Neutrophils play a role in the immunopathology SARS‐CoV‐2 infection by triggering the formation of NETs, producing cytokines including interleukin‐8 (CXCL8), and mediating the recruitment of other immune cells to regulate inflammation, which can lead to ARDS.
Maria Candida Cesta +8 more
wiley +1 more source
Identification of Surface Glycoprotein Mutations of SARS-CoV-2 in Isolated Strains from Iraq
Медицинская иммунология, 2022 Background: The global pandemic of coronavirus disease is a societal, economic, and publichealth crisis that is still underway. The spike glycoprotein of SARS-CoV-2 is one of the primary ingredients for virulence, tissue tropism, and host areas.
Ali A. Dawood +2 more
doaj +1 more source
Epigenetic mechanisms regulating COVID-19 infection
Epigenetics, 2021 Coronavirus disease 2019 (COVID-2019) outbreak originating in December 2019 in Wuhan, China has emerged as a global threat to human health. The highly contagious SARS-CoV-2 infection and transmission presents a diversity of human host and increased ...
Sarantis Chlamydas +2 more
doaj +1 more source
Tetracycline as an inhibitor to the coronavirus SARS-CoV-2 [PDF]
J Cell Biochem (2021) 1-8, 2020 The coronavirus SARS-CoV-2 remains an extant threat against public health on a global scale. Cell infection begins when the spike protein of SARS-CoV-2 binds with the cell receptor, angiotensin-converting enzyme 2 (ACE2). Here, we address the role of Tetracycline as an inhibitor for the receptor-binding domain (RBD) of the spike protein.
arxiv +1 more source
ACE2 and Diabetes: ACE of ACEs? [PDF]
Diabetes, 2010 The mechanisms involved in the development of diabetes and its complications are complex, with a long list of potential derangements on different pathways (1,2). In this commentary, we discuss angiotensin converting enzyme 2 (ACE2) as a potential participant in the development of both islet β-cell insufficiency early on and in the development of ...
Daniel Batlle +2 more
openaire +3 more sources
ACE2 in the renin–angiotensin system
Clinical Science, 2020 AbstractIn 2020 we are celebrating the 20th anniversary of the angiotensin-converting enzyme 2 (ACE2) discovery. This event was a landmark that shaped the way that we see the renin–angiotensin system (RAS) today. ACE2 is an important molecular hub that connects the RAS classical arm, formed mainly by the octapeptide angiotensin II (Ang II) and its ...
Verano-Braga, Thiago +4 more
openaire +3 more sources
TCM2COVID: A resource of anti‐COVID‐19 traditional Chinese medicine with effects and mechanisms
iMeta, Volume 1, Issue 4, December 2022., 2022 TCM2COVID documents over 280 traditional Chinese medicine formulas (including over 300 herbs) with detailed clinical evidence and therapeutic mechanism information; TCM2COVID records over 80 natural products with detailed potential therapeutic mechanisms; TCM2COVID launches a useful web server for querying, analyzing, and visualizing documented ...
Liping Ren +9 more
wiley +1 more source