Results 51 to 60 of about 77,670 (298)
Independent Tendency of ACE2 and GRP78 Expression in SARS-CoV2 Infection
Mutiara Medika, 2022 Severe acute respiratory syndrome-coronavirus 2 (SARS-CoV2) is a virus that attacks the respiratory tract and causes the COVID-19 pandemic. This virus utilizes the host receptor as a cellular entry. Angiotensin-converting enzyme 2 (ACE2) has been assumed
Arya Adiningrat, Sekar Hasna Khairunnisa
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SARS-CoV-2 Entry Genes Are Most Highly Expressed in Nasal Goblet and Ciliated Cells within Human Airways [PDF]
Nature Medicine, 2020, 2020 The SARS-CoV-2 coronavirus, the etiologic agent responsible for COVID-19 coronavirus disease, is a global threat. To better understand viral tropism, we assessed the RNA expression of the coronavirus receptor, ACE2, as well as the viral S protein priming protease TMPRSS2 thought to govern viral entry in single-cell RNA-sequencing (scRNA-seq) datasets ...
arxiv +1 more source
Effect of age on human ACE2 and ACE2-expressing alveolar type II cells levels
Pediatric Research, 2022 Angiotensin-converting enzyme 2 (ACE2) is the receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) which causes COVID-19. Viral entry requires ACE2 and transmembrane protease serine 2 (TMPRSS2). Transcriptomic studies showed that children display lower ACE2 than adults, though gene expression levels do not always correlate with ...
Silva, Mauro Gastón +9 more
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The Two Faces of ACE2: The Role of ACE2 Receptor and Its Polymorphisms in Hypertension and COVID-19 [PDF]
Molecular Therapy - Methods & Clinical Development, 2020 The mechanism for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection requires the binding of the virus to the angiotensin-converting enzyme 2 (ACE2) receptor, well-known for its role in counteracting ACE. ACE2 is involved in modulating blood pressure and establishing blood pressure homeostasis.
Bosso, Mira +5 more
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Peptide‐based covalent inhibitors of protein–protein interactions
Journal of Peptide Science, Volume 29, Issue 1, January 2023., 2023 Peptide interaction motifs derived from a protein–protein interaction interface can serve as starting points for the development of inhibitors. However, for certain proteins when applying competitive inhibitors, peptide‐based ligands with an irreversible binding mode may be more active. This review summarizes examples of covalent inhibitors that employ
Felix M. Paulussen, Tom N. Grossmann
wiley +1 more source
International Journal of COPD, 2022 Samuel James Brake,1 Mathew Suji Eapen,1 Kielan Darcy McAlinden,1 James Markos,1,2 Greg Haug,1,2 Josie Larby,1,2 Collin Chia,1,2 Ashutosh Hardikar,1,3 Gurpreet Kaur Singhera,4,5 Tillie L Hackett,4,5 Wenying Lu,1 Sukhwinder Singh Sohal1 1Respiratory ...
Brake SJ +11 more
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Is Covid-19 severity associated with ACE2 degradation? [PDF]
arXiv, 2021 Covid-19 is particularly mild with children, and its severity escalates with age. Several theories have been proposed to explain these facts. In particular, it was proposed that the lower expression of the viral receptor ACE2 in children protects them from severe Covid.
arxiv
The Discovery of the ACE2 Gene [PDF]
Circulation Research, 2013 The discovery of the ACE2 gene broadened the scope of the regulatory mechanisms that govern the biological effects of the renin–angiotensin system in the cardiovascular system and beyond The late Daniel E. Koshland Jr. (1920–2007), a former editor of Science (1985–1995), characterized scientific discoveries into 3 categories of Charge, Challenge, and
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Molecular Aspects of Spike–ACE2 Interaction [PDF]
Encyclopedia, 2022 A new betacoronavirus (CoV-2) is responsible for the pandemic of severe acute respiratory syndrome (SARS) that began in China at the end of 2019, today known as COronaVIrus Disease 2019 (COVID-19). Subsequent studies confirmed the human angiotensin-converting enzyme 2 (hACE2) as the main cell receptor of spike trimeric glycoprotein, located on the ...
Luigi De Masi +3 more
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HYPERGLYCEMIA ON THE BACKGROUND OF TREATMENT OF COVID-19-ASSOCIATED PNEUMONIA USING GLUCOCORTICOIDS
Juvenis Scientia, 2021 The pandemic of coronavirus pneumonia caused by SARS-CoV-2 virus and its multiple complications are a global issue of the day. Coronavirus infection is more severe in patients having chronic concomitant diseases.
A. V. Alimov +6 more
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