بررسی رابطه بين مقادير سمی جنتامايسين و فعاليت آنزيم تبديلکننده آنژيوتنسين در کليه، ريه و سرم موش صحرايی [PDF]
, 2002 آنزيم تبديل کننده آنژيوتانسين ( ACE ( با اثر روی مولکول غيرفعال آنژيوتانسين (AngI) I آن را تبديل به مولکول فعال آنژيوتانسين (AngII)II مینمايد. بافتهای اپیتليومی، اندوتليومی و نورواپیتليالی منبع ACE هستند.
صالحيان, پیروز +2 more
core
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
Российский кардиологический журнал, 2009 The manifold studies on ACE gene impact on left ventricular hypertrophy (LVH) development in hypertrophic cardiomyopathy (HCMP) and arterial hypertension (AH) have provided too contradictory results to clarify the association between ACE gene I/D ...
M. D. Smirnova +5 more
doaj
Development of a Spectrophotometric Method for Monitoring Angiotensin-Converting Enzyme in Dairy Products [PDF]
, 2013 The angiotensin-converting enzyme (ACE) regulates the levels of blood pressure through generation of angiotensin-II from angiotensin-I. It is of great importance to have a reliable and yet simple method for a quantitative determination ACE inhibitory ...
Julijana Tomovska*, S. Presilski, N. Gjorgievski, N. Tomovska1, M. S. Qureshi2 and N. P. Bozinovska3
core
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Agent-Based Computational Laboratories for the Experimental Study of Complex Economic Systems [PDF]
Computational laboratories (CLs) are computational frameworks that facilitate the study of complex system behaviors by means of controlled and replicable experiments.
Leigh Tesfatsion
core
Association of ACE Polymorphism and Diabetic Nephropathy in South Indian Patients [PDF]
, 2001 Objective: To study the association of ACE gene polymorphism and diabetic nephropathy in South Indian subjects. Setting: Outpatient clinic of a specialized hospital.
Bala, Karthik +7 more
core +1 more source
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Screening for novel Angiotensin I - Converting Enzyme (ACE) inhibitory peptides from Azorean Macroalgae: Extraction, purification, characterization and evaluation of their antihypertensive activity [PDF]
, 2013 Jornadas "Ciência nos Açores – que futuro? Tema Ciências Naturais e Ambiente", Ponta Delgada, 7-8 de Junho de 2013.A descoberta de inibidores naturais da ECA como alternativa às drogas sintéticas tem-se tornado de suma importância na prevenção da ...
Baptista, José +3 more
core
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source