Results 251 to 260 of about 141,407 (287)
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ACE inhibition and atherogenesis
Canadian Journal of Physiology and Pharmacology, 2002Recent clinical studies such as HOPE, SECURE, and APRES show that angiotensin-converting enzyme (ACE) inhibitors like ramipril improve the prognosis of patients with a high risk of atherothrombotic cardiovascular events. Atherosclerosis, as a chronic inflammatory condition of the vascular system, can turn into an acute clinical event through the ...
B A, Schölkens, W, Landgraf
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Clinical Pharmacology of ACE Inhibition
Cardiology, 1989The radioimmunological determinations of immunoreactive 'angiotensin II' do not truly reflect angiotensin-(1-8)octapeptide levels, and thus cannot provide an accurate reflection of the efficacy of angiotensin-converting enzyme (ACE) inhibition. Elaborate methods are necessary to measure specifically the octapeptide angiotensin II.
J, Nussberger, B, Waeber, H R, Brunner
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Circulation, 1997
Background The mechanisms by which ACE inhibitors produce a sustained clinical benefit are not entirely clear but may involve the sympathetic nervous system. We compared the effect of local brachial artery infusions of an ACE inhibitor (perindoprilat) with the effect of placebo (0.9% NaCl) on endogenously mediated (lower body ...
D, Lyons, S, Roy, S, O'Byrne, C G, Swift
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Background The mechanisms by which ACE inhibitors produce a sustained clinical benefit are not entirely clear but may involve the sympathetic nervous system. We compared the effect of local brachial artery infusions of an ACE inhibitor (perindoprilat) with the effect of placebo (0.9% NaCl) on endogenously mediated (lower body ...
D, Lyons, S, Roy, S, O'Byrne, C G, Swift
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Cardiac Effects of ACE Inhibition
Journal of Cardiovascular Pharmacology, 1993Hypertension frequently is associated with a number of changes in heart structure and function, such as left ventricular hypertrophy, disturbed diastolic function, and subnormal stroke volume during exercise. Most of these changes probably are related to myocardial fibrosis.
P, Lund-Johansen, P, Omvik
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Evidence-Based Medicine and ACE Inhibition
Journal of Cardiovascular Pharmacology, 1998The use of angiotensin-converting enzyme (ACE) inhibitors has been generally beneficial in the treatment of many clinical conditions characterized by a significant degree of cardiovascular and renal involvement. Most of the available data on the benefits of ACE inhibitors have come from well-conducted large clinical trials that have provided much ...
C, Borghi, E, Ambrosioni
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Endothelium-mediated vasodilation during ACE inhibition
European Heart Journal, 1995ACE inhibitors are superior to other vasodilators in the treatment of congestive heart failure and may be advantageous in patients with myocardial infarction and hypertension. The mechanisms mediating these beneficial effects are not clear. The present article discusses the mechanisms leading to augmented release of endothelium-derived nitric oxide ...
W, Auch-Schwelk +5 more
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ACE Inhibition in Diabetic Patients
PharmacoEconomics, 1996Diabetic nephropathy is the inevitable long term complication of prolonged hyperglycaemia for up to 40% of patients with diabetes mellitus. Most patients with renal involvement have a number of comorbid conditions including hypertension, coronary artery disease. peripheral vascular disease and retinopathy.
R A, Rodby, E J, Lewis
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Cardiovascular Drugs and Therapy, 2001
Aldosterone exerts pro-fibrotic effects, acting via mineralo-corticoid reeptors in cardiovascular tissues. Aldosterone antagonism in combination with ACE inhibition may better protect against untoward effects of aldosterone than ACE inhibition alone.In a double blind, randomised study the tolerability and efficacy of canreonate (25 mg/day) plus ...
P, Di Pasquale +5 more
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Aldosterone exerts pro-fibrotic effects, acting via mineralo-corticoid reeptors in cardiovascular tissues. Aldosterone antagonism in combination with ACE inhibition may better protect against untoward effects of aldosterone than ACE inhibition alone.In a double blind, randomised study the tolerability and efficacy of canreonate (25 mg/day) plus ...
P, Di Pasquale +5 more
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ACE Inhibition in Hypertension
American Journal of Cardiovascular Drugs, 2007Ongoing developments in our understanding of cardiovascular disease, together with the introduction of new drugs to treat these conditions, has led to much debate over the optimal management of hypertension. The ALLHAT study showed no major differences in cardiovascular outcome among three major classes of antihypertensive drugs.
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