Results 101 to 110 of about 3,911 (190)

Illicit Drug‐Derived Volatile Organic Compounds as Markers for Application in Noncontact Detection Technology

The Chemical Record, Volume 26, Issue 3, March 2026.
This review highlights the characteristic odor markers of illicit drugs, emphasizing volatile markers from both natural and synthetic sources, and explores the shift from canine‐based detection to emerging noncontact sensing technologies. Illicit drug use remains a global concern, requiring effective detection methods to counter evolving concealment ...
Minwoo Kim, Solpa Lee, Anmo J. Kim, Cong Wang, Yongwoo Jang   +4 more
wiley   +1 more source

Functional Training Mitigates Reduced Circulating Indole‐3‐Lactate Levels in Persons With Relapsing–Remitting Multiple Sclerosis

Acta Physiologica, Volume 242, Issue 3, March 2026.
ABSTRACT Aim Indoles are tryptophan (Trp)‐derived metabolites that are produced by the gut microbiota and may influence the gut‐microbiota‐brain axis in multiple sclerosis (MS). Indole‐3‐lactate (ILA) is reduced in persons with MS and improves MS clinical scores in animal models via its anti‐inflammatory remyelinating properties.
Tiffany Wences Chirino, Frederike Adammek, Sergen Belen, Matteo Winker, Sebastian Proschinger, Annette Rademacher, Marit L. Schlagheck, Alexander Schenk, Marie Kupjetz, David Walzik, Clemens Warnke, Marcel Reuter, Friederike Rosenberger, Tim Meyer, Adrian McCann, Per Magne Ueland, Niklas Joisten, Philipp Zimmer   +17 more
wiley   +1 more source

Molecular basis of antibiotic sensing by the TetR family regulator CecR – a structural perspective

The FEBS Journal, Volume 293, Issue 6, Page 1801-1817, March 2026.
Escherichia coli CecR, a member of the TetR family regulators, senses selected antibiotics and activates the expression of a putative drug efflux pump. Although present in many pathogenic Enterobacteriales strains, CecR remains poorly characterized. We present the first CecR crystal structure, which reveals a unique tunnel‐like ligand‐binding cavity ...
Agnieszka J. Pietrzyk‐Brzezinska, Anna Koczurowska, Marta Orlikowska, Maciej Nielipinski, Dominika Nielipinska, Bartosz Sekula   +5 more
wiley   +1 more source

Identification of a novel link connecting indole‐3‐acetamide with abscisic acid biosynthesis and signaling

New Phytologist, Volume 249, Issue 5, Page 2452-2466, March 2026.
Summary Plants orchestrate their developmental processes and responses to environmental stimuli through a sophisticated network of small signaling molecules, termed phytohormones. Among these, auxins are recognized for their role in promoting plant growth.
José Moya‐Cuevas, Paloma Ortiz‐García, Adrián González Ortega‐Villaizán, Irene Viguera‐Leza, Andrés Pérez‐González, Javier Paz‐Ares, Carlos Alonso‐Blanco, Jesús Vicente‐Carbajosa, Stephan Pollmann   +8 more
wiley   +1 more source

Biotrophic Interactions Between a Mycoparasitic Ampelomyces Fungus and Podosphaera xanthii on Fungicide‐Treated Melon Leaves

Plant Pathology, Volume 75, Issue 2, March–April 2026.
The digital micrographs show images of the infection progress by the mycoparasitic Ampelomyces strain in a melon powdery mildew fungus Podosphaera xanthii that was treated with kresoxim‐methyl and sprayed with Ampelomyces spores under the high‐humidity conditions of a growth chamber.
Yuito Sato, Haruna Ikoma, Márk Z. Németh, Risa Tsumura, Diána Seress, Levente Kiss, Teruo Nonomura   +6 more
wiley   +1 more source

A pilot study of maternal vitamin D status and its association with breast milk and infant gut metabolites

Physiological Reports, Volume 14, Issue 5, March 2026.
Vitamin D status in our pilot study was associated with higher levels of certain amino acids and hexanoic acid in breast milk and metabolites in infant stool samples. Abstract Human milk contains multiple bioactive components, many of which are influenced by the mother's nutritional status.
Alyssa S. Gutierrez, Katherine E. Chetta, Santosh Thapa, Sigmund J. Haidacher, Kathleen M. Hoch, John E. Baatz, Anthony M. Haag, Numan Oezguen, Thomas D. Horvath, Carol L. Wagner, Melinda A. Engevik   +10 more
wiley   +1 more source

Investigating the Ligand‐Binding Properties of N‐arylbenzimidazoles as Novel Elastase Inhibitors

ChemMedChem, Volume 21, Issue 4, 25 February 2026.
A series of novel N‐[(3,5‐dimethylphenyl)methyl]‐1H‐benzimidazole derivatives is designed, synthesized, and evaluated for inhibitory activity against elastase. Several compounds demonstrate an antielastase activity, including the N‐(2‐bromophenyl)‐2‐(6‐chloro‐1‐(3,5‐dimethylbenzyl)‐1H‐benzo[d]imidazol‐2‐ylthio)acetamide, showing the greatest potency ...
Giovanna Pitasi, Sonia Floris, Francesca Mancuso, Giulia Savoca, Rosaria Gitto, Antonella Fais, Laura De Luca   +6 more
wiley   +1 more source

A Facile Protocol for C(sp2)–C(sp3) Bond Formation Reactions Toward Functionalized E3 Ligase Ligands

ChemMedChem, Volume 21, Issue 4, 25 February 2026.
A robust C(sp2)–C(sp3) decarboxylative coupling strategy enables access to new CRBN ligands and degraders with improved physicochemical properties. This synthetic approach is expanding the chemical space beyond C(sp2)–N linkages, fine‐tuning proteolysis‐targeting chimera activities and unlocking previously inaccessible degrader chemotypes.
Anita Maksutova, Thomas M. Geiger, Lorenzo Cianni, Dominika E. Pieńkowska, Jan Gerhartz, Lina Read, Aleša Bricelj, Alexander Herrmann, Maurice Leon Nelles, Yuen Lam Dora Ng, Marcus D. Hartmann, Jan Krönke, Izidor Sosič, Radosław P. Nowak, Michael Gütschow, Christian Steinebach   +15 more
wiley   +1 more source

4‐(5‐Chloro‐3‐(3,4,5‐trimethoxybenzoyl)‐1H‐indol‐1‐yl)benzenesulfonamide: A Novel Polypharmacology Agent to Target Carbonic Anhydrase IX and XII With Improved Selectivity, Wnt/β‐Catenin Signaling Pathway, and P‐Glycoprotein

ChemMedChem, Volume 21, Issue 4, 25 February 2026.
Polypharmacology is expected to produce higher therapeutic efficacy and lower cytotoxic and side effects. Compound 15 exhibited strong inhibition of the human carbonic anhydrase isoforms IX and XII and selectivity toward the adverse isoforms I and II.
Michela Puxeddu, Rosa Bordone, Claudia Colla, Gabriele Rotili, Antonio Coluccia, Pietro Sciò, Petra Cuřínová, Alessio Nocentini, Claudiu T. Supuran, Serena Filiberti, Marta Turati, Roberto Ronca, Joanna Kopecka, Chiara Riganti, Lucia Jimenez, Wolfgang Link, Chiara Bigogno, Giulio Dondio, Martina Barba, Gianluca Canettieri, Romano Silvestri, Giuseppe La Regina   +21 more
wiley   +1 more source

Identification of α-Azacyclic Acetamide-Based Inhibitors of P. falciparum Na⁺ Pump (PfATP4) with Fast-Killing Asexual Blood-Stage Antimalarial Activity by Phenotypic Screening. [PDF]

ACS Infect Dis
Casas A, Imlay LS, Thathy V, Fairhurst KJ, Lehane AM, Lawong AK, Deni I, Striepen J, Lee S, Kumar A, Xing C, Niederstrasser H, Posner BA, Laleu B, Charman SA, Fidock DA, Ready JM, Phillips MA.   +17 more
europepmc   +1 more source