Results 111 to 120 of about 5,076 (258)
British Journal of Pharmacology, EarlyView.Abstract Background and Purpose New synthetic cannabinoid receptor agonists (SCRAs) are associated with severe adverse effects, including unexpected psychiatric symptoms. These compounds are mainly active through their potent agonism on the cannabinoid receptors CB1 and CB2.
Giorgia Corli +8 more
wiley +1 more source
, 1987 Thioacetamides and N-(3-aminothioacryloyl)formamidines can be transformed to trimethinium salts by the reaction with formamide chlorides. The same products are formed by a modified Vilsmeier-Haack-Arnold reaction of acetamides or acetonitriles.
Jürgen Liebscher +3 more
core +1 more source
Understanding how enzymes work: the journey to ensemble–function studies
The FEBS Journal, EarlyView.For decades, structure–function has dominated biochemistry. Structures are highly valuable, yet more is needed to achieve a quantitative understanding of biomolecular function, because function emerges from an ensemble of states, rather than a static structure. We describe an ensemble–function framework applied to quantitatively dissect serine protease
Daniel Herschlag, Siyuan Du
wiley +1 more source
Beilstein Journal of Organic Chemistry, 2012 A novel and reliable method for the direct preparation of 2,2-dihalo-N-phenylacetamides is reported. The key transformation involves the cleavage of a carbon–carbon bond in the presence of DIB and a Lewis acid as the halogen source, and thus this method ...
Wei-Bing Liu +3 more
doaj +1 more source
Síntese de potenciais antagonistas do receptor B1 da bradicinina contendo o heterociclo piridazinona [PDF]
, 2013 Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Físicas e Matemáticas, Programa de Pós-Graduação em Química, Florianópolis, 2013.Uma série de 4,5-di-hidro-3(2H)-piridazinonas dissubstituídas nas posições 4 e 6 do ...
Maximiano, Adrielle Patricio
core
The FEBS Journal, EarlyView.Using 1H NMR metabolomics, we measured polar and lipid metabolites from human blood neutrophils from people with frailty (n = 31, mean age 84Y), people with rheumatoid arthritis (n = 16, mean age 55Y), robust older (n = 24, mean age 66Y) and healthy younger people (n = 21, mean age 22Y).
Genna Ali Abdullah +5 more
wiley +1 more source
, 2016 Copper(I) bromide catalyzed direct C–H arylation of cyclic enamides was achieved using diaryliodonium salts in the absence of base/additive at ambient temperature with high yields.
Muthuraj Prakash (1643212) +2 more
core +1 more source
Towards an integrated molecular understanding of plant hormones
Journal of Integrative Plant Biology, EarlyView.This review offers a comprehensive overview of the nine plant hormones, delving into their biosynthesis, transport, signaling and crosstalk mechanisms. Because the complexity of plant hormonal control goes beyond these core elements, additional specific features are discussed. Lastly, this review highlights how fundamental insights drive hormonal‐based
Louise Vilain +2 more
wiley +1 more source
Tetrahedron ChemEfficient synthetic routes to pharmaceutically important 4-styrylquinazolines scaffolds are of considerable interest. Herein, we report a concise synthesis of 4-styrylquinazoline derivatives via a hypervalent iodine-promoted oxidative amination cascade ...
Lipeng Long +7 more
doaj +1 more source
Green Chemistry Letters and Reviews, 2018 The efficiency of conventional heating energy source compared with Infrared (IR), Ultrasound (US), Microwave and the simultaneous combination US–IR eco-friendly approaches for preparation of new N-(5-R1 -amino-2-nitrophenyl)acetamides and 5-R1-amino-2 ...
Ricardo A. Luna-Mora +8 more
doaj +1 more source