Results 81 to 90 of about 21,852 (266)

Investigating the Ligand‐Binding Properties of N‐arylbenzimidazoles as Novel Elastase Inhibitors

ChemMedChem, EarlyView.
A series of novel N‐[(3,5‐dimethylphenyl)methyl]‐1H‐benzimidazole derivatives is designed, synthesized, and evaluated for inhibitory activity against elastase. Several compounds demonstrate an antielastase activity, including the N‐(2‐bromophenyl)‐2‐(6‐chloro‐1‐(3,5‐dimethylbenzyl)‐1H‐benzo[d]imidazol‐2‐ylthio)acetamide, showing the greatest potency ...
Giovanna Pitasi, Sonia Floris, Francesca Mancuso, Giulia Savoca, Rosaria Gitto, Antonella Fais, Laura De Luca   +6 more
wiley   +1 more source

Synthesis and Antimicrobial Activity of Some Novel Substituted Piperazinyl-quinazolin-3(4H)-ones

E-Journal of Chemistry, 2008
Several substituted-quinazolin-3(4H)-ones were synthesized by condensation of 2-chloro-N-(4-oxo-substituted-quinazolin-3(4H)-yl)-acetamides with various substituted piperazines through single step reaction. Elemental analysis, IR, 1HNMR and mass spectral
N. M. Raghavendra, P. P. Thampi, P. M. Gurubasavarajaswamy   +2 more
doaj   +1 more source

Complementary regioselectivity in the synthesis of iminohydantoins: remarkable effect of amide substitution on the cyclization [PDF]

, 2013
Complementary regioselective synthesis of iminohydantoins from isocyanoacetamides controlled by the substituent on the amide group has been described.
García Valverde, María, González Ortega, Alfonso ., Marcaccini, Stefano ., Rodríguez Vidal, Francisco Javier, Rojo Cámara, Mª Josefa, Torroba Pérez, Tomás   +5 more
core   +1 more source

A Facile Protocol for C(sp2)–C(sp3) Bond Formation Reactions Toward Functionalized E3 Ligase Ligands

ChemMedChem, EarlyView.
A robust C(sp2)–C(sp3) decarboxylative coupling strategy enables access to new CRBN ligands and degraders with improved physicochemical properties. This synthetic approach is expanding the chemical space beyond C(sp2)–N linkages, fine‐tuning proteolysis‐targeting chimera activities and unlocking previously inaccessible degrader chemotypes.
Anita Maksutova, Thomas M. Geiger, Lorenzo Cianni, Dominika E. Pieńkowska, Jan Gerhartz, Lina Read, Aleša Bricelj, Alexander Herrmann, Maurice Leon Nelles, Yuen Lam Dora Ng, Marcus D. Hartmann, Jan Krönke, Izidor Sosič, Radosław P. Nowak, Michael Gütschow, Christian Steinebach   +15 more
wiley   +1 more source

Approach for the synthesis of N-phenylamides from β-ketobutylanilides using dimethylformamide and dimethylacetamide as the acyl donors

Journal of Saudi Chemical Society, 2015
A new method including the sequence of a CN bond formation of β-keto amides with N,N-dimethylamides and subsequently another two CN bonds cleavage has been developed in the presence of hydrochloric acid.
Cui Chen, Liquan Tan, Peng Zhou
doaj   +1 more source

Photochemical aryl radical cyclizations to give (E)-3-Ylideneoxindoles [PDF]

, 2014
(E)-3-Ylideneoxindoles are prepared in methanol in reasonable to good yields, as adducts of photochemical 5-exo-trig of aryl radicals, in contrast to previously reported analogous radical cyclizations initiated by tris(trimethylsilyl)silane and azo ...
Aldabbagh, Fawaz, Allart-Simon, Ingrid, Gerard, Stephane, Gurry, Michael, McArdle, Patrick, Sapi, Janos   +5 more
core   +2 more sources

ZnO‐Coated Silicon Oxide Nano‐Anode: Synergistic Enhancement of Cycling and Thermal Stability of Lithium‐Ion Batteries

ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
Lithium‐ion battery anodes that maintain good performance and excellent stability under high temperature conditions. Silicon oxide (SiO) has great potential as a high‐capacity anode for lithium‐ion batteries, but its practical use is limited by excessive volume expansion (>200%) and rapid capacity fade, especially at high temperatures.
Keren Shi, Wende Yi, Weikang Su, Qiaowei Xiao, Ziyan Wang, Xiaoyu Li, Jingyang Mu, Wufei Tang, Zhihan Peng, Huiqin Yao   +9 more
wiley   +1 more source

Dizajniranje i sinteza novih derivata tiofenkarbohidrazida, tienopirazola i tienopirimidina s antioksidativnim i antitumorskim djelovanjem [PDF]

, 2010
2-Amino-5-acetyl-4-methyl-thiophene-3-carboxylic acid ethyl ester (1) and 5-acetyl-2-amino-4-methylthiophene-3-carbohydrazide (2) were synthesized and used as starting materials for the synthesis of new series of 1-(5-amino-4-(3,5-dimethyl-1H-pyrazole-1 ...
A. El-Gazzar, A. El-Gazzar, A. El-Gazzar, A. Rosowsky, Ameen Abu-Hashem, E. Lissi, Farid Badria, G. Nikolakopoulos, H. Hafez, H. Lütjens, I. Heiba, K. Dore, K. Gewald, K. Ghakraborti, L. Aurelio, M. Nassan, Mohamed El-Shehry, R. Aeschlach, R. Jarvest, S. Sasaki, T. Brown, T. Fujita, V. Alagarsamy, W. Lichen, Y. Morimoto   +24 more
core   +3 more sources

A Photoredox Radical‐Polar Crossover Reaction for the Preparation of Monoprotected Dicarbonyl Compounds

European Journal of Organic Chemistry, EarlyView.
An ATRA‐based, Ru‐photocatalyzed radical‐polar crossover reaction for the preparation of monoprotected dicarbonyl compounds is reported. This procedure is based on the capture of a cationic intermediate, arising from the radical step, with diverse nucleophiles.
Derek Mota‐Hernández, Luis Antonio Vázquez‐López, Alejandro Cordero‐Vargas   +2 more
wiley   +1 more source

N-(Thiazol-2-yl)acetamide [PDF]

Acta Crystallographica Section E Structure Reports Online, 2008
The title compound, C(5)H(6)N(2)OS, was synthesized from acetyl chloride and 2-amino-thia-zole in dry acetone. The asymmetric unit contains two mol-ecules. The crystal structure is stabilized by N-H⋯N and C-H⋯O hydrogen bonds.
Uzma Yunus, Muhammad Kalim Tahir, Moazzam Hussain Bhatti, Wai-Yeung Wong   +3 more
openaire   +3 more sources