Results 11 to 20 of about 127,361 (186)
A dog model for acetaminophen-induced fulminant hepatic failure. [PDF]
, 1989 The development of a large animal model of fulminant hepatic failure produced with acetaminophen that should be useful in the development and evaluation of potential medical therapies for the important clinical problem of fulminant hepatic failure is ...
Barone, M +7 more
core +2 more sources
NQO2 is a reactive oxygen species generating off-target for acetaminophen [PDF]
, 2014 [Image: see text] The analgesic and antipyretic compound acetaminophen (paracetamol) is one of the most used drugs worldwide. Acetaminophen overdose is also the most common cause for acute liver toxicity.
Ahn K. S. +45 more
core +4 more sources
PLoS ONE, 2015 Metabolomics approaches have enabled the study of new mechanisms of liver injury in experimental models of drug toxicity. Disruption of bile acid homeostasis is a known mechanism of drug induced liver injury.
Laura James +8 more
doaj +1 more source
Acetaminophen overdose associated with double serum concentration peaks [PDF]
Journal of Community Hospital Internal Medicine Perspectives, 2015 Acetaminophen is the most commonly used analgesic–antipyretic medication in the United States. Acetaminophen overdose, a frequent cause of drug toxicity, has been recognized as the leading cause of fatal and non-fatal hepatic necrosis.
Cristian Papazoglu +4 more
doaj +1 more source
Emergency Department Pain Management Following Implementation of a Geriatric Hip Fracture Program [PDF]
, 2017 Introduction: Over 300,000 patients in the United States sustain low-trauma fragility hip fractures annually. Multidisciplinary geriatric fracture programs (GFP) including early, multimodal pain management reduce morbidity and mortality. Our overall goal
Casey, Scott D +6 more
core +4 more sources
False positive acetaminophen concentrations in icteric serum
Practical Laboratory Medicine, 2016 Introduction: Serum concentrations of acetaminophen are measured to predict the risk of hepatotoxicity in cases of acetaminophen overdose and to identify acetaminophen use in patients with acute liver injury without a known cause.
L. de Jong +4 more
doaj +1 more source
Bananas decrease acetaminophen potency in in vitro assays. [PDF]
PLoS ONE, 2018 Edible portions of bananas contain high levels of polyphenol oxidase, which catalyzes reactions in the melanin formation pathway. Tyrosine, a physiological substrate of polyphenol oxidase, has an analogous structure to acetaminophen.
Yoshihiro Uesawa, Naotaka Tsuji
doaj +1 more source
Western Journal of Emergency Medicine, 2018 Introduction: Rhabdomyolysis and delayed acetaminophen hepatotoxicity may be associated with elevated serum transaminase values. Establishing the cause of elevated transaminases may be especially difficult because of limited or inaccurate histories of ...
Joshua B. Radke +6 more
doaj +1 more source
Acetaminophen Hepatotoxicity [PDF]
Seminars in Liver Disease, 2019 AbstractAcetaminophen (APAP) is one of the most popular and safe pain medications worldwide. However, due to its wide availability, it is frequently implicated in intentional or unintentional overdoses where it can cause severe liver injury and even acute liver failure (ALF).
Anup, Ramachandran, Hartmut, Jaeschke
openaire +2 more sources
Ahi Evran Medical Journal, 2022 Purpose: Acetaminophen is safe analgesic drug but it may cause hepatic failure in high doses. N-acetyl cysteine (NAC) is used in the treatment of acetaminophen intoxication.
Hasan Gazi UYAR +5 more
doaj +1 more source