Results 11 to 20 of about 136,607 (334)

A Dog Model for Acetaminophen-Induced Fulminant Hepatic Failure [PDF]

, 1989
The development of a large animal model of fulminant hepatic failure produced with acetaminophen that should be useful in the development and evaluation of potential medical therapies for the important clinical problem of fulminant hepatic failure is ...
A. Francavilla, L Makowka, Lorenzo Polimeno, M. Barone, Jake Demetris, John Prelich, David H. Van Thiel, Thomas E. Starzl   +7 more
core   +4 more sources

Safety of ibuprofen in infants younger than six months: A retrospective cohort study. [PDF]

PLoS ONE, 2018
OBJECTIVE:We hypothesized (1) that gastrointestinal (GI) and renal adverse events (AE) would occur more often in infants first prescribed ibuprofen before rather than after six months of age and (2) that ibuprofen would be associated with more adverse ...
Paul Walsh, Stephen J Rothenberg, Heejung Bang   +2 more
doaj   +5 more sources

NQO2 is a reactive oxygen species generating off-target for acetaminophen [PDF]

, 2014
[Image: see text] The analgesic and antipyretic compound acetaminophen (paracetamol) is one of the most used drugs worldwide. Acetaminophen overdose is also the most common cause for acute liver toxicity.
Ahn K. S., Andersson D. A., Antoine M., Bajt M. L., Bantscheff M., Bessems J. G., Buryanovskyy L., Celli C. M., Cheung C., Chung C. W., Cohen S. D., Cover C., Dahlin D. C., Forman H. J., Fu Y., Graham G. G., Graves P. R., Jaeschke H., James L. P., James L. P., Janbaz K. H., Kheradpezhouh E., Knight T. R., Knox R. J., Laukkanen M. O., Liao S., Lister C. F., Long D. J., Manyike P. T., Martinez Molina D., McGill M. R., Miettinen T. P., Mikael Björklund, Moore M., Moynihan R., Niesen F. H., Nosjean O., Reybier K., Sener G., Shah A. D., Shuhendler A. J., Teemu P. Miettinen, Tirmenstein M. A., Tripathy D., Vella F., Winger J. A.   +45 more
core   +3 more sources

Contemporary management of pain in cirrhosis: Toward precision therapy for pain

Hepatology, EarlyView., 2022
Abstract Chronic pain is highly prevalent in patients with cirrhosis and is associated with poor health‐related quality of life and poor functional status. However, there is limited guidance on appropriate pain management in this population, and pharmacologic treatment can be harmful, leading to adverse outcomes, such as gastrointestinal bleeding ...
Alexis Holman, Neehar Parikh, Dan J. Clauw, David A. Williams, Elliot B. Tapper   +4 more
wiley   +1 more source

Macrophage‐derived MLKL in alcohol‐associated liver disease: Regulation of phagocytosis

Hepatology, EarlyView., 2022
EtOH causes leaky gut allowing bacteria and PAMPs into the liver, resulting in hepatic inflammation and injury. We demonstrate that LPS induces STAT1‐mediated expression and phosphorylation of MLKL in macrophages and identify a novel function that myeloid MLKL translocates to phagosomes and lysosomes and regulates phagocytosis, which contributes to the
Xiaoqin Wu, Xiude Fan, Megan R. McMullen, Tatsunori Miyata, Adam Kim, Vai Pathak, Jianguo Wu, Le Z. Day, Josiah E. Hardesty, Nicole Welch, Jaividhya Dasarathy, Daniela S. Allende, Arthur J. McCullough, Jon M. Jacobs, Daniel M. Rotroff, Srinivasan Dasarathy, Laura E. Nagy   +16 more
wiley   +1 more source

The effects of diclofenac suppository and intravenous acetaminophen and their combination on the severity of postoperative pain in patients undergoing spinal anaesthesia during cesarean section [PDF]

, 2016
Introduction: The main tasks of postoperative care are postoperative pain and complications control which play an important role in accelerating the recovery of patient’s general condition. Aim: This study was performed in order to compare the effects of
Aryaie, M., Bakhsha, F., Jafari, S.Y., Niaki, A.S., Yousefi, Z.   +4 more
core   +1 more source

Combinatorial targeting of G‐protein‐coupled bile acid receptor 1 and cysteinyl leukotriene receptor 1 reveals a mechanistic role for bile acids and leukotrienes in drug‐induced liver injury

Hepatology, EarlyView., 2022
CHIN117 is a dual cysteinyl leukotriene receptor 1 (CYSLTR1) antagonist and G‐protein‐coupled bile acid receptor 1 (GPBAR1) agonist. In the liver, GPBAR1 and CYSLTR1 are coexpressed by liver sinusoidal endothelial cells (LSECs), HSCs, circulating monocytes/macrophages, and liver resident macrophages (Kupffer cells).
Michele Biagioli, Silvia Marchianò, Cristina di Giorgio, Rosalinda Roselli, Martina Bordoni, Rachele Bellini, Bianca Fiorillo, Valentina Sepe, Bruno Catalanotti, Chiara Cassiano, Maria Chiara Monti, Eleonora Distrutti, Angela Zampella, Stefano Fiorucci   +13 more
wiley   +1 more source

Transaminase and Creatine Kinase Ratios for Differentiating Delayed Acetaminophen Overdose from Rhabdomyolysis

Western Journal of Emergency Medicine, 2018
Introduction: Rhabdomyolysis and delayed acetaminophen hepatotoxicity may be associated with elevated serum transaminase values. Establishing the cause of elevated transaminases may be especially difficult because of limited or inaccurate histories of ...
Joshua B. Radke, Douglas A. Algren, James A. Chenoweth, Kelly P. Owen, Jonathan B. Ford, Timothy E. Albertson, Mark E. Sutter   +6 more
doaj   +1 more source

Acetaminophen overdose associated with double serum concentration peaks [PDF]

Journal of Community Hospital Internal Medicine Perspectives, 2015
Acetaminophen is the most commonly used analgesic–antipyretic medication in the United States. Acetaminophen overdose, a frequent cause of drug toxicity, has been recognized as the leading cause of fatal and non-fatal hepatic necrosis.
Cristian Papazoglu, Jonathan R. Ang, Michael Mandel, Prasanta Basak, Stephen Jesmajian   +4 more
doaj   +1 more source

Acetaminophen for osteoarthritis

Cochrane Database of Systematic Reviews, 2006
Osteoarthritis (OA) is the most common form of arthritis. Published guidelines and expert opinion are divided over the relative role of acetaminophen (also called paracetamol or Tylenol) and non-steroidal anti-inflammatory drugs (NSAIDs) as first-line pharmacologic therapy.
Tanveer Towheed, Lara J Maxwell, Marc C. Hochberg, George A. Wells, Maria Judd, Michelle Catton   +5 more
openaire   +4 more sources