Results 11 to 20 of about 113,832 (239)

Acetaminophen Hepatotoxicity [PDF]

Seminars in Liver Disease, 2019
AbstractAcetaminophen (APAP) is one of the most popular and safe pain medications worldwide. However, due to its wide availability, it is frequently implicated in intentional or unintentional overdoses where it can cause severe liver injury and even acute liver failure (ALF).
Anup, Ramachandran, Hartmut, Jaeschke
openaire   +3 more sources

Acetaminophen use and risk of renal impairment: A systematic review and meta-analysis

Kidney Research and Clinical Practice, 2020
Background : : Acetaminophen is commonly used for the relief of pain and fever. Advocacy organizations recommend acetaminophen as the drug of choice in patients with kidney disease.
Sukrit Kanchanasurakit, Aimusa Arsu, Wuttikorn Siriplabpla, Acharaporn Duangjai, Surasak Saokaew   +4 more
doaj   +2 more sources

Management of Acetaminophen Poisoning in the US and Canada: A Consensus Statement.

JAMA Network Open, 2023
Importance The US and Canada currently have no formal published nationwide guidelines for specialists in poison information or emergency departments for the management of acetaminophen poisoning, resulting in significant variability in management ...
R. Dart, M. Mullins, Theresa Matoushek, A. Ruha, M. Burns, Karen E. Simone, M. Beuhler, K. Heard, M. Mazer-Amirshahi, C. Stork, S. Varney, A. Funk, L. Cantrell, J. Cole, W. Banner, A. Stolbach, R. Hendrickson, S. Lucyk, M. Sivilotti, M. Su, Lewis Nelson, B. Rumack   +21 more
semanticscholar   +1 more source

Paracetamol (acetaminophen): A familiar drug with an unexplained mechanism of action

Temperature, 2021
Paracetamol (acetaminophen) is undoubtedly one of the most widely used drugs worldwide. As an over-the-counter medication, paracetamol is the standard and first-line treatment for fever and acute pain and is believed to remain so for many years to come ...
S. Ayoub
semanticscholar   +1 more source

Regular Acetaminophen Use and Blood Pressure in People With Hypertension: The PATH-BP Trial

Circulation, 2022
Supplemental Digital Content is available in the text. Background: Acetaminophen is widely used as first-line therapy for chronic pain because of its perceived safety and the assumption that, unlike nonsteroidal anti-inflammatory drugs, it has little or ...
I. Macintyre, E. Turtle, T. Farrah, C. Graham, J. Dear, D. Webb   +5 more
semanticscholar   +1 more source

Early Postoperative Acetaminophen Administration and Severe Acute Kidney Injury After Cardiac Surgery.

American Journal of Kidney Diseases, 2022
RATIONALE & OBJECTIVE Oxidative stress may contribute to the development of acute kidney injury (AKI) after cardiac surgery. Acetaminophen can be considered an antioxidant as it inhibits hemoprotein-catalyzed lipid peroxidation.
C. Xiong, Yuan Jia, Xie Wu, Yanyan Zhao, S. Yuan, Fuxia Yan, Daniel I. Sessler   +6 more
semanticscholar   +1 more source

Prenatal and postnatal exposure to acetaminophen in relation to autism spectrum and attention-deficit and hyperactivity symptoms in childhood: Meta-analysis in six European population-based cohorts

European Journal of Epidemiology, 2021
The potential etiological role of early acetaminophen exposure on Autism Spectrum Conditions (ASC) and Attention-Deficit/Hyperactivity Disorder (ADHD) is inconclusive. We aimed to study this association in a collaborative study of six European population-
S. Alemany, Claudia Avella-Garcia, Z. Liew, R. Garcia-Esteban, Kosuke Inoue, T. Cadman, Mónica López-Vicente, Llúcia González, Isolina Riaño Galán, Ainara Andiarena, M. Casas, K. Margetaki, K. Strandberg-Larsen, D. Lawlor, H. El Marroun, H. Tiemeier, C. Íñiguez, A. Tardón, L. Santa-Marina, J. Júlvez, D. Porta, L. Chatzi, J. Sunyer   +22 more
semanticscholar   +1 more source

Analgesic Effect of Acetaminophen: A Review of Known and Novel Mechanisms of Action

Frontiers in Pharmacology, 2020
Acetaminophen is one of the most commonly used analgesic agents for treating acute and chronic pain. However, its metabolism is complex, and its analgesic mechanisms have not been completely understood.
Nobuko Ohashi, T. Kohno
semanticscholar   +1 more source

Comparison of Bile Acids and Acetaminophen Protein Adducts in Children and Adolescents with Acetaminophen Toxicity.

PLoS ONE, 2015
Metabolomics approaches have enabled the study of new mechanisms of liver injury in experimental models of drug toxicity. Disruption of bile acid homeostasis is a known mechanism of drug induced liver injury.
Laura James, Ke Yan, Lisa Pence, Pippa Simpson, Sudeepa Bhattacharyya, Pritmohinder Gill, Lynda Letzig, Gregory Kearns, Richard Beger   +8 more
doaj   +1 more source

Acetaminophen overdose associated with double serum concentration peaks [PDF]

Journal of Community Hospital Internal Medicine Perspectives, 2015
Acetaminophen is the most commonly used analgesic–antipyretic medication in the United States. Acetaminophen overdose, a frequent cause of drug toxicity, has been recognized as the leading cause of fatal and non-fatal hepatic necrosis.
Cristian Papazoglu, Jonathan R. Ang, Michael Mandel, Prasanta Basak, Stephen Jesmajian   +4 more
doaj   +1 more source