Results 21 to 30 of about 136,607 (334)

Development of an invasively monitored porcine model of acetaminophen-induced acute liver failure [PDF]

, 2010
Background: The development of effective therapies for acute liver failure (ALF) is limited by our knowledge of the pathophysiology of this condition, and the lack of suitable large animal models of acetaminophen toxicity.
A Francavilla, Alistair Lee, BG Gazzard, C Trey, Celine Filippi, Chris Bellamy, Costas Dabos, D Henne-Bruns, DJ Jollow, DJ Miller, Forbes Howie, G Schmid, H Bismuth, J Terblanche, JH Kelly, JK Nicholson, JN Plevris, John N Plevris, JR Mitchell, JV Dacie, LE Schmidt, Leonard J Nelson, LF Prescott, LJ Nelson, MC Savides, N Agar, Neil C Henderson, OW Griffith, Peter C Hayes, Philip N Newsome, PN Newsome, PN Newsome, RC Blantz, Richard E Clutton, SL Nash, SV Baudouin, T Matsubara, Tim King   +37 more
core   +4 more sources

Emergency Department Pain Management Following Implementation of a Geriatric Hip Fracture Program [PDF]

, 2017
Introduction: Over 300,000 patients in the United States sustain low-trauma fragility hip fractures annually. Multidisciplinary geriatric fracture programs (GFP) including early, multimodal pain management reduce morbidity and mortality. Our overall goal
Casey, Scott D, Hirsch, Calvin H, Mumma, Bryn E, Slee, Christina, Stevenson, Dane E, Tyler, Katren, Wolinsky, Philip R   +6 more
core   +4 more sources

Acetaminophen use and risk of renal impairment: A systematic review and meta-analysis

Kidney Research and Clinical Practice, 2020
Background : : Acetaminophen is commonly used for the relief of pain and fever. Advocacy organizations recommend acetaminophen as the drug of choice in patients with kidney disease.
Sukrit Kanchanasurakit, Aimusa Arsu, Wuttikorn Siriplabpla, Acharaporn Duangjai, Surasak Saokaew   +4 more
doaj   +1 more source

Comparison of N-Acetyl Cysteine and Resveratrol Treatments in Acetaminophen Toxicity Model in Rabbits

Ahi Evran Medical Journal, 2022
Purpose: Acetaminophen is safe analgesic drug but it may cause hepatic failure in high doses. N-acetyl cysteine (NAC) is used in the treatment of acetaminophen intoxication.
Hasan Gazi UYAR, Aysegül BAYIR, Hasan KARA, Pınar KARABAĞLI, Abdullah SİVRİKAYA, Ali UNLU   +5 more
doaj   +1 more source

Acetaminophen-cysteine adducts during therapeutic dosing and following overdose

BMC Gastroenterology, 2011
Background Acetaminophen-cysteine adducts (APAP-CYS) are a specific biomarker of acetaminophen exposure. APAP-CYS concentrations have been described in the setting of acute overdose, and a concentration >1.1 nmol/ml has been suggested as a marker of ...
Judge Bryan S, James Laura P, Green Jody L, Heard Kennon J, Zolot Liza, Rhyee Sean, Dart Richard C   +6 more
doaj   +1 more source

Using a decision tree algorithm to distinguish between repeated supra-therapeutic and acute acetaminophen exposures

BMC Medical Informatics and Decision Making, 2023
Background This study aimed to compare clinical and laboratory characteristics of supra-therapeutic (RSTI) and acute acetaminophen exposures using a predictive decision tree (DT) algorithm.
Omid Mehrpour, Christopher Hoyte, Samaneh Nakhaee, Bruno Megarbane, Foster Goss   +4 more
doaj   +1 more source

Drug Hepatotoxicity: Environmental Factors [PDF]

, 2017
Drug-induced liver injury presents as various forms of acute and chronic liver disease. There is wide geographic variation in the most commonly implicated agents.
Chalasani, Naga P., Stine, Jonathan G.
core   +1 more source

Acute effects of acetaminophen on the developmental, swimming performance and cardiovascular activities of the African catfish embryos/larvae (Clarias gariepinus)

Ecotoxicology and Environmental Safety, 2021
Acetaminophen is a widely used analgesic that has been detected in many water bodies with few reports concerning its potential toxicity to fish. This study sought to assess the developmental, swimming performance and cardiovascular activities of embryo ...
Nosakhare Osazee Erhunmwunse, Isioma Tongo, Lawrence Ikechukwu Ezemonye   +2 more
doaj  

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

Adverse effect profile comparison of pain regimens with and without intravenous acetaminophen in total hip and knee arthroplasty patients

SAGE Open Medicine, 2017
Background: The use of adjunct, non-opioid agents is integral for pain control following total hip and knee arthroplasty. Literature comparing safety profiles of intravenous acetaminophen versus opioids is lacking.
Alyssa Gallipani, A Scott Mathis, Hoytin Lee Ghin, Germin Fahim   +3 more
doaj   +1 more source