Results 21 to 30 of about 113,832 (239)

Association of Cord Plasma Biomarkers of In Utero Acetaminophen Exposure With Risk of Attention-Deficit/Hyperactivity Disorder and Autism Spectrum Disorder in Childhood.

JAMA psychiatry, 2020
Importance Prior studies have raised concern about maternal acetaminophen use during pregnancy and increased risk of attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) in their children; however, most studies have relied ...
Yuelong Ji, Romuladus Azuine, Yan Zhang, Wenpin Hou, X. Hong, Guoying Wang, A. Riley, C. Pearson, B. Zuckerman, Xiaobin Wang   +9 more
semanticscholar   +1 more source

False positive acetaminophen concentrations in icteric serum

Practical Laboratory Medicine, 2016
Introduction: Serum concentrations of acetaminophen are measured to predict the risk of hepatotoxicity in cases of acetaminophen overdose and to identify acetaminophen use in patients with acute liver injury without a known cause.
L. de Jong, D.G. Knapen, T.H. Oude Munnink, M.J. Henstra, T.F. Veneman   +4 more
doaj   +1 more source

Bananas decrease acetaminophen potency in in vitro assays. [PDF]

PLoS ONE, 2018
Edible portions of bananas contain high levels of polyphenol oxidase, which catalyzes reactions in the melanin formation pathway. Tyrosine, a physiological substrate of polyphenol oxidase, has an analogous structure to acetaminophen.
Yoshihiro Uesawa, Naotaka Tsuji
doaj   +1 more source

Effect of Intravenous Acetaminophen vs Placebo Combined With Propofol or Dexmedetomidine on Postoperative Delirium Among Older Patients Following Cardiac Surgery: The DEXACET Randomized Clinical Trial

Journal of the American Medical Association (JAMA), 2019
Importance Postoperative delirium is common following cardiac surgery and may be affected by choice of analgesic and sedative. Objective To evaluate the effect of postoperative intravenous (IV) acetaminophen (paracetamol) vs placebo combined with IV ...
B. Subramaniam, Puja Shankar, S. Shaefi, Ariel Mueller, B. O'Gara, V. Banner-Goodspeed, Jacqueline Gallagher, Doris Gasangwa, Melissa Patxot, Senthil Packiasabapathy, P. Mathur, M. Eikermann, D. Talmor, E. Marcantonio   +13 more
semanticscholar   +1 more source

Transaminase and Creatine Kinase Ratios for Differentiating Delayed Acetaminophen Overdose from Rhabdomyolysis

Western Journal of Emergency Medicine, 2018
Introduction: Rhabdomyolysis and delayed acetaminophen hepatotoxicity may be associated with elevated serum transaminase values. Establishing the cause of elevated transaminases may be especially difficult because of limited or inaccurate histories of ...
Joshua B. Radke, Douglas A. Algren, James A. Chenoweth, Kelly P. Owen, Jonathan B. Ford, Timothy E. Albertson, Mark E. Sutter   +6 more
doaj   +1 more source

Acetaminophen-Induced Hepatotoxicity: a Comprehensive Update

Journal of Clinical and Translational Hepatology, 2016
Hepatic injury and subsequent hepatic failure due to both intentional and non-intentional overdose of acetaminophen (APAP) has affected patients for decades, and involves the cornerstone metabolic pathways which take place in the microsomes within ...
Eric D. Yoon, A. Babar, M. Choudhary, M. Kutner, N. Pyrsopoulos   +4 more
semanticscholar   +1 more source

Comparison of N-Acetyl Cysteine and Resveratrol Treatments in Acetaminophen Toxicity Model in Rabbits

Ahi Evran Medical Journal, 2022
Purpose: Acetaminophen is safe analgesic drug but it may cause hepatic failure in high doses. N-acetyl cysteine (NAC) is used in the treatment of acetaminophen intoxication.
Hasan Gazi UYAR, Aysegül BAYIR, Hasan KARA, Pınar KARABAĞLI, Abdullah SİVRİKAYA, Ali UNLU   +5 more
doaj   +1 more source

Comparison of Acetaminophen (Paracetamol) With Ibuprofen for Treatment of Fever or Pain in Children Younger Than 2 Years

JAMA Network Open, 2020
Key Points Question Are there differences in the antipyretic, analgesic, and safety profiles of acetaminophen (paracetamol) compared with ibuprofen for the short-term treatment of fever or pain in children younger than 2 years?
Eunicia Tan, I. Braithwaite, C. McKinlay, S. Dalziel   +3 more
semanticscholar   +1 more source

Association of Prenatal Acetaminophen Exposure Measured in Meconium With Risk of Attention-Deficit/Hyperactivity Disorder Mediated by Frontoparietal Network Brain Connectivity.

JAMA pediatrics, 2020
Importance Despite evidence of an association between prenatal acetaminophen exposure and attention-deficit/hyperactivity disorder (ADHD) in offspring, the drug is not contraindicated during pregnancy, possibly because prior studies have relied on ...
B. Baker, C. Lugo-Candelas, Haotian Wu, H. Laue, A. Boivin, V. Gillet, Natalie Aw, Tonima Rahman, J. Lepage, K. Whittingstall, J. Bellenger, J. Posner, L. Takser, A. Baccarelli   +13 more
semanticscholar   +1 more source

Acetaminophen-cysteine adducts during therapeutic dosing and following overdose

BMC Gastroenterology, 2011
Background Acetaminophen-cysteine adducts (APAP-CYS) are a specific biomarker of acetaminophen exposure. APAP-CYS concentrations have been described in the setting of acute overdose, and a concentration >1.1 nmol/ml has been suggested as a marker of ...
Judge Bryan S, James Laura P, Green Jody L, Heard Kennon J, Zolot Liza, Rhyee Sean, Dart Richard C   +6 more
doaj   +1 more source