Results 31 to 40 of about 136,607 (334)

Conjugation of nitrated acetaminophen to Der p1 amplifies peripheral blood monocyte response to Der p1.

PLoS ONE, 2017
BACKGROUND:An association of acetaminophen use and asthma was observed in the International Study of Asthma and Allergies in Childhood study. However there are no clear mechanisms to explain an association between acetaminophen use and immunologic ...
Ryan G Thomas, Brenda M Rivera Reyes, Benjamin M Gaston, Nelki B Rivera Acosta, Ilya R Bederman, Laura A Smith, Morgan T Sutton, Benlian Wang, John F Hunt, Tracey L Bonfield   +9 more
doaj   +1 more source

Extracorporeal liver assist device to exchange albumin and remove endotoxin in acute liver failure: Results of a pivotal pre-clinical study [PDF]

, 2015
Background & AimsIn acute liver failure, severity of liver injury and clinical progression of disease are in part consequent upon activation of the innate immune system.
Aggarwal, Antoine, B. Kevin Park, Banares, Banwari Agarwal, Carolina Jimenez Palacios, Christopher E. Goldring, Daniel J. Antoine, D’Souza, Fausto Andreola, Fisher, Garcia-Martinez, Giacomo Stanzani, Hatim Alibhai, Honore, Imaeda, Jaeschke, Jalan, Jalan, Karla C.L. Lee, Kribben, Lee, Lee, Liu, Lu, Luisa A. Baker, Maher, Martin-Murphy, Millis, Mookerjee, Morgera, Morgera, Morgera, Morgera, Morgera, Nathan A. Davies, Nystrom, Oettl, Oettl, Pamela J. Leckie, Paola Giordano, Rademacher, Rajeshwar P. Mookerjee, Rajiv Jalan, Rifai, Rimmele, Rosalind E. Jenkins, Saliba, Scaffidi, Sen, Shah, Simon L. Priestnall, Simpson, Stadlbauer, Su, Su, Szabo, Vaquero, Venereau, Yang, Yu Mei Chang, Yumoto   +61 more
core   +1 more source

The Dangers of Acetaminophen for Neurodevelopment Outweigh Scant Evidence for Long-Term Benefits

Children, 2023
Based on available data that include approximately 20 lines of evidence from studies in laboratory animal models, observations in humans, correlations in time, and pharmacological/toxicological considerations, it has been concluded without reasonable ...
William Parker, Lauren G. Anderson, John P. Jones, Rachel Anderson, Lauren Williamson, Dillan Bono-Lunn, Zacharoula Konsoula   +6 more
doaj   +1 more source

Mass spectrometry in ocular drug research

Mass Spectrometry Reviews, EarlyView., 2023
Abstract Mass spectrometry (MS) has been proven as an excellent tool in ocular drug research allowing analyzes from small samples and low concentrations. This review begins with a short introduction to eye physiology and ocular pharmacokinetics and the relevance of advancing ophthalmic treatments.
Eva M. del Amo, Kati‐Sisko Vellonen, Arto Urtti, Tetsuya Terasaki, Anam Hammid, Paavo Honkakoski, Seppo Auriola   +6 more
wiley   +1 more source

Acetaminophen Overdose as a Potential Risk Factor for Parkinson's Disease

Clinical and Translational Science, 2019
Four complementary approaches were used to investigate acetaminophen overdose as a risk factor for Parkinson's disease (PD). Circulating microRNAs (miRNAs) serum profiles from acetaminophen‐overdosed patients were compared with patients with terminal PD,
Sacha Bohler, Xiaosong Liu, Julian Krauskopf, Florian Caiment, Jiri Aubrecht, Gerry A. F. Nicolaes, Jos C. S. Kleinjans, Jacco J. Briedé   +7 more
doaj   +1 more source

Association of Prenatal Acetaminophen Exposure Measured in Meconium With Adverse Birth Outcomes in a Canadian Birth Cohort

Frontiers in Pediatrics, 2022
BackgroundThe small number of studies examining the association of prenatal acetaminophen with birth outcomes have all relied on maternal self-report.
Brennan H. Baker, Heather H. Burris, Tessa R. Bloomquist, Amélie Boivin, Virginie Gillet, Annie Larouche, Larissa Takser, Larissa Takser, Jean-Philippe Bellenger, Jean-Charles Pasquier, Andrea A. Baccarelli   +10 more
doaj   +1 more source

Interaction of Aldehyde dehydrogenase with acetaminophen as examined by spectroscopies and molecular docking

Biochemistry and Biophysics Reports, 2017
The interaction of acetaminophen, a non-substrate anionic ligand, with Aldehyde Dehydrogenase was studied by fluorescence, UV–Vis absorption, and circular dichroism spectroscopies under simulated physiological conditions.
Ayodele O. Kolawole
doaj   +1 more source

Intravenous vs oral acetaminophen in sinus surgery: A randomized clinical trial

Laryngoscope Investigative Otolaryngology, 2020
Background Multimodal perioperative analgesia including acetaminophen is recommended by current guidelines. The comparative efficacy of intravenous vs oral acetaminophen in sinus surgery is unknown.
Ravi Bhoja, Matthew W. Ryan, Kevin Klein, Abu Minhajuddin, Emily Melikman, Mohamed Hamza, Bradley F. Marple, David L. McDonagh   +7 more
doaj   +1 more source

Towards synthetic biological approaches to resource utilization on space missions. [PDF]

, 2015
This paper demonstrates the significant utility of deploying non-traditional biological techniques to harness available volatiles and waste resources on manned missions to explore the Moon and Mars. Compared with anticipated non-biological approaches, it
Arkin, Adam P, Cumbers, John, Hogan, John A, Menezes, Amor A   +3 more
core   +2 more sources

Biomimetic Nanomedicines Deliver Naringin for Enhanced Acute Liver Failure Therapy via Balanced Regulation of Hepatocyte Oxidative Stress and Kupffer Cell Inflammation

Advanced Functional Materials, EarlyView.
A biomimetic nanomedicine (RBLN) constructed by loading natural antioxidants to clinically used layered double hydroxide nanoparticles is surface coated with fresh or senescent red blood cell membrane for balanced drug delivery to hepatocytes and KCs, thereby simultaneously alleviating liver oxidant stress and inflammation for effective drug‐induced ...
Jiahui Shao, Maoze Wang, Jinling Huang, Yu Wang, Jing Zhao, Ran Wang, Zhi Ping Xu, Jianping Jiang, Lingxiao Zhang   +8 more
wiley   +1 more source