Results 41 to 50 of about 1,574,591 (292)

An Infant Milk Formula Supplemented with Heat-Treated Probiotic Bifidobacterium animalis subsp. lactis CECT 8145, Reduces Fat Deposition in C. elegans and Augments Acetate and Lactate in a Fermented Infant Slurry

Foods, 2020
Pediatric obesity has a growing health and socio-economical impact due to cardiovascular and metabolic complications in adult life. Some recent studies suggest that live or heat-treated probiotics have beneficial effects in preventing fat deposition and ...
Ángela Silva, Nuria Gonzalez, Ana Terrén, Antonio García, Juan Francisco Martinez-Blanch, Vanessa Illescas, Javier Morales, Marcos Maroto, Salvador Genovés, Daniel Ramón, Patricia Martorell, Empar Chenoll   +11 more
doaj   +1 more source

Ulipristal Acetate versus Leuprolide Acetate for Uterine Fibroids [PDF]

New England Journal of Medicine, 2012
The efficacy and side-effect profile of ulipristal acetate as compared with those of leuprolide acetate for the treatment of symptomatic uterine fibroids before surgery are unclear.In this double-blind noninferiority trial, we randomly assigned 307 patients with symptomatic fibroids and excessive uterine bleeding to receive 3 months of daily therapy ...
Donnez J1, Tomaszewski J, Vázquez F, Bouchard P, Lemieszczuk B, Baró F, Nouri K, Selvaggi L, Sodowski K, Bestel E, Terrill P, Osterloh I, Loumaye E, THE PEARL II Study Group, MELIS, GIAN BENEDETTO   +14 more
openaire   +2 more sources

In Vitro Evaluation of Eslicarbazepine Delivery via Enteral Feeding Tubes [PDF]

, 2017
Purpose: The feasibility of preparing an eslicarbazepine acetate suspension using Aptiom tablets for administration via enteral feeding tubes was evaluated.
Dave, Vivek S, Hughes, Susan, Reindel, Kristin, Zhao, Fang   +3 more
core   +2 more sources

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Short-Chain Fatty Acids Differentially Affect Intracellular Lipolysis in a Human White Adipocyte Model

Frontiers in Endocrinology, 2018
Background and aimsGut-derived short-chain fatty acids (SCFA), formed by microbial fermentation of dietary fibers, are believed to be involved in the etiology of obesity and diabetes.
Johan W. E. Jocken, Johan W. E. Jocken, Manuel A. González Hernández, Nicole T. H. Hoebers, Christina M. van der Beek, Christina M. van der Beek, Yvonne P. G. Essers, Ellen E. Blaak, Ellen E. Blaak, Emanuel E. Canfora, Emanuel E. Canfora   +10 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Synthesis and crystal structure of one new Pb(II) complex constructed by 1,10-phenanthroline and two carboxylate ligands

Main Group Metal Chemistry, 2021
The complex [Pb(phen)(4-NB)(CH3COO)] of lead(II) was prepared and characterized by means of elemental analysis, FT-IR, and single crystal X-ray analysis, where phen = 1,10-phenanthroline, 4-NB = 4-nitrobenzoate.
Zhang Lu-Lin, Tang Shi-Li, Li De-Jun, Cheng Yuan-Zheng, Zhang Li-Ping   +4 more
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

The Role of Active Site Residues in ATP Binding and Catalysis in the Methanosarcina thermophila Acetate Kinase

Life, 2015
Acetate kinase (ACK), which catalyzes the reversible phosphorylation of acetate by ATP, is a member of the acetate and sugar kinase/heat shock cognate/actin (ASKHA) superfamily. ASKHA family members share a common core fold that includes an ATPase domain
Cheryl Ingram-Smith, Jeffrey Wharton, Christian Reinholz, Tara Doucet, Rachel Hesler, Kerry Smith   +5 more
doaj   +1 more source

5α-Dihydrovespertilin acetate [PDF]

Acta Crystallographica Section E Structure Reports Online, 2010
In the title compound, C(24)H(36)O(4) [systematic name: (20S)-3β-acet-oxy-16α-hydr-oxy-22,23-bis-nor-5α,17β-cholano(22-16)lac-tone], the three six-membered rings adopt classical chair conformations, while the five-membered rings are in envelope conformations. The ester group attached to ring A is in an equatorial position.
Benn, Michael, Vohra, Kanwal Nain, Parvez, Masood   +2 more
openaire   +2 more sources