Results 51 to 60 of about 29,036 (224)

Design, synthesis and biological activity of selective hCAs inhibitors based on 2-(benzylsulfinyl)benzoic acid scaffold [PDF]

, 2019
A large library of derivatives based on the scaffold of 2-(benzylsulfinyl)benzoic acid were synthesised and tested as atypical inhibitors against four different isoforms of human carbonic anhydrase (hCA I, II, IX and XII, EC 4.2.1.1).
Akdemir, A., Amoroso, R., Angeli, A., Carradori, S., Cirilli, R., De Filippis, B., De Monte, C., Guglielmi, P., Maccallini, C., Rotondi, G., Secci, D., Supuran, C. T.   +11 more
core   +2 more sources

”Not always the magic bullet”—Insufficient seizure control by ketogenic dietary therapies in Glut1 Deficiency Syndrome

Epilepsia Open, EarlyView.
Abstract Objective Ketogenic dietary therapies (KDTs) are the treatment of choice for Glut1 Deficiency Syndrome (Glut1DS), providing dietary ketones as an alternative fuel to the brain and effectively controlling seizures. Recent evidence indicates insufficient seizure control in Glut1DS patients despite adequate KDT and ketosis.
Joerg Klepper, Eva Runkel, Lucia Kiesel
wiley   +1 more source

Phosphorylation and protonation of neighboring MiRP2 sites: function and pathophysiology of MiRP2-Kv3.4 potassium channels in periodic paralysis. [PDF]

, 2006
MinK-related peptide 2 (MiRP2) and Kv3.4 subunits assemble in skeletal muscle to create subthreshold, voltage-gated potassium channels. MiRP2 acts on Kv3.4 to shift the voltage dependence of activation, speed recovery from inactivation, suppress ...
Abbott, Geoffrey W, Butler, Margaret H, Goldstein, Steve AN   +2 more
core   +1 more source

Potentiation of Synaptic GluN2B NMDAR Currents by Fyn Kinase Is Gated through BDNF-Mediated Disinhibition in Spinal Pain Processing [PDF]

, 2016
In chronic pain states, the neurotrophin brain-derived neurotrophic factor (BDNF) transforms the output of lamina I spinal neurons by decreasing synaptic inhibition.
Beggs, S, Dedek, A, Hildebrand, ME, Li, Y, Lombroso, PJ, Salter, MW, Sengar, AS, Xu, J   +7 more
core   +1 more source

Acetazolamide as an Add-on Therapy Following Barbed Reposition Pharyngoplasty in Obstructive Sleep Apnea: A Randomized Controlled Trial

Life
Surgical interventions, like barbed reposition pharyngoplasty (BRP), are a valuable alternative for patients with obstructive sleep apnea (OSA) who are unable to tolerate continuous positive airway pressure (CPAP).
Simon Hellemans, Eli Van de Perck, Dorine Van Loo, Johan Verbraecken, Scott A. Sands, Ali Azarbarzin, Marijke Dieltjens, Sara Op De Beeck, Anneclaire Vroegop, Olivier M. Vanderveken   +9 more
doaj   +1 more source

Influence of sulfite on ATPase activity of coupling factor CF(1) isolated from spinach chloroplasts [PDF]

The Ukrainian Biochemical Journal, 2019
The present study of sulfite participation in the regulation of the chloroplast ATP-synthase complex can help to understand the mechanisms of acid rains toxic effects on the plant photosynthetic apparatus.
O. B. Onoiko , A. P. Khomochkin , O. K. Zolotareva   +2 more
doaj   +1 more source

A Single Drop in the Eye – Effects on the Whole Body [PDF]

, 2017
Peer ...
Vaajanen, Anu, Vapaatalo, Heikki
core   +2 more sources

Update on Medical Treatments for Essential Tremor: An International Parkinson and Movement Disorder Society Evidence‐Based Medicine Review

Movement Disorders, EarlyView.
Abstract Background The first International Parkinson and Movement Disorder Society Evidence‐Based Medicine (MDS‐EBM) review for essential tremor (ET) was published in 2019; since then, the modified Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) methodology was adopted by MDS, and new evidence exists.
Deepa Dash, Verónica Bruno, Petra Schwingenschuh, Kelly E. Lyons, Eng‐King Tan, Claudia M. Testa, Santiago Perez Lloret, Bettina Balint, João Costa, Rob M.A. de Bie, Monty A. Silverdale, Ai Huey Tan, Tiago A. Mestre   +12 more
wiley   +1 more source

Simultaneous Cerebral Blood Flow and Cerebrovascular Reactivity Obtained From Novel Multi‐Band Multi‐Echo Pseudo‐Continuous Arterial Spin Labeling (M2‐PCASL) Sequence: A Test–Retest Reliability Study

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose We aim to assess the reliability of cerebral blood flow (CBF) and cerebrovascular reactivity (CVR) obtained simultaneously from a novel multi‐band pseudo‐continuous arterial spin labeling (M2‐PCASL) sequence and hypercapnic gas challenge, to examine factors influencing CBF variability, and to evaluate the impact of carbon dioxide (CO2)
Jody Todd, Maria‐Julieta Mateos, Ibraheem Budeir, Deqiang Qiu   +3 more
wiley   +1 more source

Effects of acetazolamide on exercise performance in patients with COPD going to high altitude: randomised controlled trial

ERJ Open Research
Background In patients with COPD, preventive treatment with acetazolamide reduces adverse health effects during altitude travel. We investigated whether preventive acetazolamide treatment modifies exercise performance in COPD patients going to high ...
Roman F. Kind, Michael Furian, Aline Buergin, Philipp M. Scheiwiller, Laura Mayer, Simon R. Schneider, Mona Lichtblau, Lara Muralt, Maamed Mademilov, Talant M. Sooronbaev, Silvia Ulrich, Konrad E. Bloch   +11 more
doaj   +1 more source