Results 81 to 90 of about 34,477 (255)
Uncovering the impact of the cardiovascular system on cerebrovascular health using MRI
Experimental Physiology, EarlyView.Abstract Human cerebrovasculature is finely tuned to enable local changes in blood flow to meet the brain's demands, whilst protecting the brain from systemic changes in blood pressure, both acutely during a heartbeat and chronically over time. This review summarises cerebrovascular structure and function, their role in disease and neurodegeneration ...
Ian D. Driver, Kevin Murphy
wiley +1 more source
Optimizing cerebrovascular endothelial health through shear stress modulation
Experimental Physiology, EarlyView.Abstract The endothelium plays a pivotal role in regulating cerebrovascular blood flow, and its dysfunction increases the risk of cerebrovascular disease. Endothelial shear stress, a primary mechanical stimulus for endothelial nitric oxide production, is a key modulator of vascular adaptation.
Erika Iwamoto +2 more
wiley +1 more source
Patients' Perceptions and Treatment Effectiveness [PDF]
An extensive literature relating patients’ expectations to treatment outcomes has not addressed the determinants of these expectations. We argue that treatment history is part of a reference point that influences patients’ expectations of how effective ...
Dan Firesner +3 more
core
How do physiological networks respond to normobaric hypoxia and isometric exercise?
Experimental Physiology, EarlyView.Abstract The dynamics of physiological systems are impacted by both exercise and hypoxia. Network models can be used to map the interactions between various physiological components in environmental physiology and exercise using the concepts of information theory.
Danilo Bondi +6 more
wiley +1 more source
Ocular administration of acetazolamide microsponges in situ gel formulations
Saudi Pharmaceutical Journal, 2018 In the present work, the antiglaucoma drug, acetazolamide, was formulated as microsponges in situ gel for ocular drug delivery aiming an improved therapeutic efficacy and reduction in the systemic side effects of oral acetazolamide. The microsponges were
Manar M. Obiedallah +2 more
doaj +1 more source
Retinitis pigmentosa-associated cystoid macular oedema: pathogenesis and avenues of intervention [PDF]
, 2016 Hereditary retinal diseases are now the leading cause of blindness certification in the working age population (age 16-64 years) in England and Wales, of which retinitis pigmentosa (RP) is the most common disorder.
Liew, G, Michaelides, M, Strong, S
core +1 more source
Neurobiology of Disease, 2005 We investigated the involvement of calcium-activated potassium channel (BK) in skeletal muscle phenotype determination and response to acetazolamide, a BK opener.
Domenico Tricarico +2 more
doaj +1 more source
, 2006 Andersen-Tawil syndrome (ATS) is a rare condition consisting of ventricular arrhythmias, periodic paralysis, and dysmorphic features. In 2001, mutations in KCNJ2, which encodes the α subunit of the potassium channel Kir2.1, were identified in patients ...
Fish, Frank A +2 more
core +2 more sources
Design, synthesis and biological activity of selective hCAs inhibitors based on 2-(benzylsulfinyl)benzoic acid scaffold [PDF]
, 2019 A large library of derivatives based on the scaffold of 2-(benzylsulfinyl)benzoic acid were synthesised and tested as atypical inhibitors against four different isoforms of human carbonic anhydrase (hCA I, II, IX and XII, EC 4.2.1.1).
Akdemir, A. +11 more
core +2 more sources