Results 111 to 120 of about 250,937 (292)
The NADPH oxidase NOX4 regulates redox and metabolic homeostasis preventing HCC progression
Hepatology, EarlyView., 2022 Loss of NOX4 in HCC tumor cells induces metabolic reprogramming in a Nrf2/MYC‐dependent manner to promote HCC progression. Abstract Background and Aims The NADPH oxidase NOX4 plays a tumor‐suppressor function in HCC. Silencing NOX4 confers higher proliferative and migratory capacity to HCC cells and increases their in vivo tumorigenic potential in ...
Irene Peñuelas‐Haro +14 more
wiley +1 more source
Pharmacological ResearchAcetyl-CoA is a central metabolite that links energy status to transcriptional regulation through protein acetylation, yet its functions in skeletal biology depend strongly on subcellular compartmentalization.
Qianyu Yang +4 more
doaj +1 more source
RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease
Hepatology, EarlyView., 2022 RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease. Abstract Background and Aims Receptor‐interacting protein kinase 3 (RIPK3) mediates NAFLD progression, but its metabolic function is unclear. Here, we aimed to investigate the role of RIPK3 in modulating mitochondria function, coupled with lipid droplet (LD)
Marta B. Afonso +16 more
wiley +1 more source
Hepatology, EarlyView., 2022 CHIN117 is a dual cysteinyl leukotriene receptor 1 (CYSLTR1) antagonist and G‐protein‐coupled bile acid receptor 1 (GPBAR1) agonist. In the liver, GPBAR1 and CYSLTR1 are coexpressed by liver sinusoidal endothelial cells (LSECs), HSCs, circulating monocytes/macrophages, and liver resident macrophages (Kupffer cells).
Michele Biagioli +13 more
wiley +1 more source
)‐Methylsuccinyl‐CoA dehydrogenase closes the ethylmalonyl‐CoA pathway for acetyl‐CoA assimilation
, 2009 Many organic substrates are metabolized via acetyl-coenzyme A (CoA) and enter central carbon metabolism at the level of this compound. We recently described the outlines of the ethylmalonyl-CoA pathway, a new acetyl-CoA assimilation strategy that ...
Georg Fuchs +5 more
core +1 more source
Acetyl CoA metabolism -- overview
, 1997 Major metabolic sources of acetyl CoA and some of the processes in which it serves as a ...
core
One‐Pot Biphasic Photocatalytic CO2‐to‐Carbonylation Cascades
Angewandte Chemie International Edition, EarlyView.Bioinspired biphasic compartmentalization enables one‐pot cascades where photocatalytic CO2 reduction generates CO for carbonylative cross‐couplings to synthesize complex organic products, including a pharmaceutical. ABSTRACT Photosynthesis compartmentalizes reactions across the thylakoid membrane in vivo to upcycle CO2 into complex chemicals that are ...
Sampurna Mitra +3 more
wiley +1 more source
Stimulation of acetyl‐CoA carboxylase by (−)‐Hydroxycitrate [PDF]
FEBS Letters, 1972 Hackenschmidt, J., Barth, C., Decker, K.
openaire +2 more sources
Induction of phosphorylation and acetylation by acetyl-CoA.
, 2016 A. Induction of acetyl-CoA in mitochondria by palmitate. Mitochondria were isolated from cells after palmitate treatment (300 μM) at 1, 4 and 16 h, and then used in the concentration assay of acetyl-CoA. B.
Bilun Ke (553335) +5 more
core +1 more source
Journal of the American Oil Chemists' Society, EarlyView.The manuscript confirms and expands on previous reports concerning the presence of unusual conjugated hydroxydienoic fatty acids and acetyl‐TAG in the seed oil of Securidaca longipedunculata. The location of acetate only at sn‐2 of TAG was conclusively shown by high resolution NMR and hydroxy seed fatty acids are characterized.
Mark A. Smith +2 more
wiley +1 more source