Results 11 to 20 of about 38,176 (241)

Purification of Native Acetyl CoA Carboxylase From Mammalian Cells [PDF]

Bio-Protocol
Fatty acid (FA) biosynthesis is a crucial cellular process that converts nutrients into metabolic intermediates necessary for membrane biosynthesis, energy storage, and the production of signaling molecules. Acetyl-CoA carboxylase (ACACA) plays a pivotal
Yaxue Sun, Jiachen Li, Lianmei Zhao, Hongtao Zhu   +3 more
doaj   +2 more sources

Alternative polyadenylation regulates acetyl-CoA carboxylase function in peanut [PDF]

BMC Genomics, 2023
Background Polyadenylation is a crucial process that terminates mRNA molecules at their 3′-ends. It has been observed that alternative polyadenylation (APA) can generate multiple transcripts from a single gene locus, each with different polyadenylation ...
Zhenying Peng, Shuang Yu, Jingjing Meng, Kai-Hua Jia, Jialei Zhang, Xinguo Li, Wenwei Gao, Shubo Wan   +7 more
doaj   +2 more sources

Plant acetyl-CoA carboxylase: The homomeric form and the heteromeric form [PDF]

BBA Advances
Across the domains of life, the enzyme acetyl-CoA carboxylase (ACC) converts HCO3−, ATP, and acetyl-CoA to malonyl-CoA, ADP, and Pi. Malonyl-CoA is the building block for all de novo fatty acid biosynthesis.
Dilawar Niazi, Greg B.G. Moorhead
doaj   +2 more sources

Acetyl-CoA carboxylase maintains energetic balance for functional oogenesis [PDF]

Nature Communications
Reproduction is tightly linked to nutrient availability and metabolic homeostasis, yet how specific metabolic pathways coordinate with cellular signaling to control oogenesis remains unclear.
Oyundari Amartuvshin, Chi-Hung Lin, Yi-Ting Ke, Han-Jung Lee, Kreeti Kajal, Tsai-Ling Huang, Wen-Der Wang, Tsai-Ming Lu, Ling-Huei Yih, Chen-Yuan Tseng, Hwei-Jan Hsu   +10 more
doaj   +2 more sources

Repurposing a human acetyl-CoA carboxylase inhibitor firsocostat to treat fungal candidiasis alone and in combination [PDF]

Antimicrob Agents Chemother, 2023
Tianyu Chen, Jing Yao, Keao Quan, Jingchen Xu, Xudong Hang, Qiang Tong, Genyan Liu, Peipei Luo, Liping Zeng, Ganzhu Feng, Hongkai Bi   +10 more
openalex   +2 more sources

Chloroflexus aurantiacus acetyl-CoA carboxylase evolves fused biotin carboxylase and biotin carboxyl carrier protein to complete carboxylation activity [PDF]

mBio
Acetyl-CoA carboxylases (ACCs) convert acetyl-CoA to malonyl-CoA, a key step in fatty acid biosynthesis and autotrophic carbon fixation pathways. Three functionally distinct components, biotin carboxylase (BC), biotin carboxyl carrier protein (BCCP), and
Jiejie Shen, Wenping Wu, Kangle Wang, Jingyi Wu, Bing Liu, Chunyang Li, Zijun Gong, Xin Hong, Han Fang, Xingwei Zhang, Xiaoling Xu   +10 more
doaj   +2 more sources

Solution Structure and NMR Chemical Shift Perturbations of the Arabidopsis BCCP1 Identify Intersubunit Interactions Potentially Involved in the Assembly of the Heteromeric Acetyl‐CoA Carboxylase [PDF]

Plant Direct
Biotin carboxyl carrier protein (BCCP) is a subunit of the heteromeric acetyl‐CoA carboxylase (htACCase), and it chemically links the two half‐reactions that constitute the formation of malonyl‐CoA from acetyl‐CoA, a critical reaction in fatty acid ...
Kiran‐Kumar Shivaiah, Ganesh P. Subedi, Adam W. Barb, Basil J. Nikolau   +3 more
doaj   +2 more sources

Arachidonate and medium-chain fatty acids inhibit transcription of the acetyl-CoA carboxylase gene in hepatocytes in culture

Journal of Lipid Research, 1997
Transcription of acetyl-CoA carboxylase in avian liver is low during starvation or after consumption of a low-carbohydrate, high-fat diet and high during consumption of a high-carbohydrate, low-fat diet.
F B Hillgartner, T Charron
doaj   +1 more source

Lipocalin‐2 activates hepatic stellate cells and promotes nonalcoholic steatohepatitis in high‐fat diet–fed Ob/Ob mice

Hepatology, EarlyView., 2022
Graphical summary of obesity‐induced NASH progression by LCN2 targeted to HSC activation. Abstract Background and Aims In obesity and type 2 diabetes mellitus, leptin promotes insulin resistance and contributes to the progression of NASH via activation of hepatic stellate cells (HSCs).
Kyung Eun Kim, Jaewoong Lee, Hyun Joo Shin, Eun Ae Jeong, Hye Min Jang, Yu Jeong Ahn, Hyeong Seok An, Jong Youl Lee, Meong Cheol Shin, Soo Kyoung Kim, Won Gi Yoo, Won Ho Kim, Gu Seob Roh   +12 more
wiley   +1 more source

Docking of acetyl-CoA carboxylase to the plastid envelope membrane attenuates fatty acid production in plants

Nature Communications, 2020
In plants, light-dependent activation fatty acid synthesis (FAS) is mediated in part by acetyl-CoA carboxylase (ACCase). Here the authors identify a family of genes encoding carboxyltransferase interactors that attenuate FAS in the light by docking ...
Yajin Ye, Krisztina Nikovics, Alexandra To, Loïc Lepiniec, Eric T. Fedosejevs, Steven R. Van Doren, Sébastien Baud, Jay J. Thelen   +7 more
doaj   +1 more source