Targeting acetyl-CoA carboxylase 1 for cancer therapy [PDF]
Frontiers in Pharmacology, 2023 Metabolic adaptation is an emerging hallmark of tumors. De novo fatty acid synthesis is an important metabolic process to produce metabolic intermediates for energy storage, biosynthesis of membrane lipids and generation of signaling molecules.
Yong Yu +5 more
doaj +3 more sources
The dynamic organization of fungal acetyl-CoA carboxylase [PDF]
Nature Communications, 2016 Acetyl-CoA carboxylases are central regulatory hubs of fatty acid metabolism and are important targets for drug development in obesity and cancer. Here, the authors demonstrate that the regulation of these highly dynamic enzymes in fungi is governed by a
Moritz Hunkeler +4 more
doaj +9 more sources
Inhibition of acetyl-CoA carboxylase suppresses fatty acid synthesis and tumor growth of non-small-cell lung cancer in preclinical models [PDF]
Nature Medicine, 2016 Continuous de novo fatty acid synthesis is a common feature of cancer that is required to meet the biosynthetic demands of a growing tumor. This process is controlled by the rate-limiting enzyme acetyl-CoA carboxylase (ACC), an attractive but ...
Matthew J Kolar +2 more
exaly +4 more sources
Acetyl-CoA-Carboxylase 1-mediated de novo fatty acid synthesis sustains Lgr5+ intestinal stem cell function [PDF]
Nature Communications, 2022 Here the authors report that inhibition of de novo fatty acid synthesis by deleting the enzyme Acetyl-CoA-Carboxylase 1 in the intestinal epithelium results in the loss of crypt structures and a specific decline in Lgr5+ intestinal epithelial stem cells.
Shuting Li +14 more
doaj +3 more sources
Chemical Genetics of Acetyl-CoA Carboxylases [PDF]
Molecules, 2013 Chemical genetic studies on acetyl-CoA carboxylases (ACCs), rate-limiting enzymes in long chain fatty acid biosynthesis, have greatly advanced the understanding of their biochemistry and molecular biology and promoted the use of ACCs as targets for ...
Xuyu Zu +9 more
doaj +7 more sources
Nature Communications, 2020 In plants, light-dependent activation fatty acid synthesis (FAS) is mediated in part by acetyl-CoA carboxylase (ACCase). Here the authors identify a family of genes encoding carboxyltransferase interactors that attenuate FAS in the light by docking ...
Yajin Ye +7 more
doaj +2 more sources
Purification of Native Acetyl CoA Carboxylase From Mammalian Cells [PDF]
Bio-ProtocolFatty acid (FA) biosynthesis is a crucial cellular process that converts nutrients into metabolic intermediates necessary for membrane biosynthesis, energy storage, and the production of signaling molecules. Acetyl-CoA carboxylase (ACACA) plays a pivotal
Yaxue Sun +3 more
doaj +2 more sources
Alternative polyadenylation regulates acetyl-CoA carboxylase function in peanut [PDF]
BMC Genomics, 2023 Background Polyadenylation is a crucial process that terminates mRNA molecules at their 3′-ends. It has been observed that alternative polyadenylation (APA) can generate multiple transcripts from a single gene locus, each with different polyadenylation ...
Zhenying Peng +7 more
doaj +2 more sources
Fine-tuning acetyl-CoA carboxylase 1 activity through localization: functional genomics reveals a role for the lysine acetyltransferase NuA4 and sphingolipid metabolism in regulating Acc1 activity and localization [PDF]
Genetics, 2022 Acetyl-CoA Carboxylase 1 catalyzes the conversion of acetyl-CoA to malonyl-CoA, the committed step of de novo fatty acid synthesis. As a master regulator of lipid synthesis, acetyl-CoA carboxylase 1 has been proposed to be a therapeutic target for ...
T. Pham +5 more
semanticscholar +3 more sources
Acetyl-CoA carboxylase 1 is a suppressor of the adipocyte thermogenic program [PDF]
Cell Reports, 2023 Summary: Disruption of adipocyte de novo lipogenesis (DNL) by deletion of fatty acid synthase (FASN) in mice induces browning in inguinal white adipose tissue (iWAT). However, adipocyte FASN knockout (KO) increases acetyl-coenzyme A (CoA) and malonyl-CoA
Adilson Guilherme +18 more
doaj +2 more sources