Results 261 to 270 of about 86,728 (368)
Extracellular Vesicles in Nonalcoholic Fatty Liver Disease: Mechanisms and Therapeutic Opportunities
The role of extracellular vesicles (EVs) in the progression of nonalcoholic fatty liver disease (NAFLD). Donor cells release EVs containing various molecules such as cholesterol, ceramide, sphingomyelin, miRNA, DNA, proteins, and lipids. These EVs are taken up by multiple recipient cells including Kupffer cells, adipocytes, β cells, adipose tissue ...
Yunsheng Dong +12 more
wiley +1 more source
ABSTRACT Background Suppression of the peroxisome proliferator‐activated receptor alpha (PPARα) has been related to poor outcomes in sepsis and may compromise ketogenesis during critical illness. Infusion of 3‐hydroxybutyrate (3HB) was shown to attenuate muscle weakness in septic mice.
Caroline Lauwers +12 more
wiley +1 more source
Depletion of Acetyl-CoA Carboxylase 1 Facilitates Epithelial-Mesenchymal Transition in Prostate Cancer Cells by Activating the MAPK/ERK Pathway. [PDF]
Lai J +15 more
europepmc +1 more source
Biotinoyl Domain of Human Acetyl-CoA Carboxylase;Structural Insights into the Carboxyl Transfer Mechanism [PDF]
Chung-Kyung Lee +5 more
openalex +1 more source
Cancer is a complex tumor system consisting of tumor cells, immune effector cells, and all the matrix components. The intricate interactions among cells and molecular signaling pathways in this microenvironment jointly drive tumor growth, invasion, and metastasis, and significantly influence the efficacy of cancer treatment. Meanwhile, the treatment of
Ying Sun +11 more
wiley +1 more source
Regulation of human Th9 cell differentiation by lipid modulators targeting PPAR-γ and acetyl-CoA-carboxylase 1. [PDF]
Peesari S, McAleer JP.
europepmc +1 more source
Alcohol‐related (ALD) and metabolic dysfunction‐associated (MASLD) steatotic liver disease, while initiated by distinct etiologies (ethanol vs. metabolic stress), converge on shared core pathogenic pathways that drive progression. These include dysregulated lipid metabolism, programmed cell death, cellular senescence, gut dysbiosis, and immune ...
Yupin Tan +3 more
wiley +1 more source

