Results 261 to 270 of about 86,728 (368)

Extracellular Vesicles in Nonalcoholic Fatty Liver Disease: Mechanisms and Therapeutic Opportunities

open access: yesiNew Medicine, Volume 1, Issue 1, December 2025.
The role of extracellular vesicles (EVs) in the progression of nonalcoholic fatty liver disease (NAFLD). Donor cells release EVs containing various molecules such as cholesterol, ceramide, sphingomyelin, miRNA, DNA, proteins, and lipids. These EVs are taken up by multiple recipient cells including Kupffer cells, adipocytes, β cells, adipose tissue ...
Yunsheng Dong   +12 more
wiley   +1 more source

Ketogenic Nutrition in Combination With PPARα Activation Induced Metabolic Failure and Exacerbated Muscle Weakness in Septic Mice

open access: yesJournal of Cachexia, Sarcopenia and Muscle, Volume 16, Issue 6, December 2025.
ABSTRACT Background Suppression of the peroxisome proliferator‐activated receptor alpha (PPARα) has been related to poor outcomes in sepsis and may compromise ketogenesis during critical illness. Infusion of 3‐hydroxybutyrate (3HB) was shown to attenuate muscle weakness in septic mice.
Caroline Lauwers   +12 more
wiley   +1 more source

Depletion of Acetyl-CoA Carboxylase 1 Facilitates Epithelial-Mesenchymal Transition in Prostate Cancer Cells by Activating the MAPK/ERK Pathway. [PDF]

open access: yesMedComm (2020)
Lai J   +15 more
europepmc   +1 more source

Biotinoyl Domain of Human Acetyl-CoA Carboxylase;Structural Insights into the Carboxyl Transfer Mechanism [PDF]

open access: bronze, 2008
Chung-Kyung Lee   +5 more
openalex   +1 more source

Dynamic Evolution of the Tumor Immune Microenvironment in Malignant Tumors and Emerging Therapeutic Paradigms

open access: yesMedComm, Volume 6, Issue 12, December 2025.
Cancer is a complex tumor system consisting of tumor cells, immune effector cells, and all the matrix components. The intricate interactions among cells and molecular signaling pathways in this microenvironment jointly drive tumor growth, invasion, and metastasis, and significantly influence the efficacy of cancer treatment. Meanwhile, the treatment of
Ying Sun   +11 more
wiley   +1 more source

Differential regulation of the yeast isozymes of pyruvate carboxylase and the locus of action of acetyl CoA

open access: green, 2007
Sarawut Jitrapakdee   +6 more
openalex   +1 more source

Alcohol‐Related Liver Disease and Metabolic Dysfunction‐Associated Steatotic Liver Disease: Molecular Pathogenesis and Therapeutic Interventions

open access: yesMedComm, Volume 6, Issue 12, December 2025.
Alcohol‐related (ALD) and metabolic dysfunction‐associated (MASLD) steatotic liver disease, while initiated by distinct etiologies (ethanol vs. metabolic stress), converge on shared core pathogenic pathways that drive progression. These include dysregulated lipid metabolism, programmed cell death, cellular senescence, gut dysbiosis, and immune ...
Yupin Tan   +3 more
wiley   +1 more source

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