Results 271 to 280 of about 92,949 (326)

High Citrate-Dependent Overactivation of Acetyl CoA Carboxylase Leads to Ectopic Kidney Lipid Accumulation and Mitochondrial Dysfunction in a CKD Model

Marta Sanz‐Gómez, Elvira Bragado García, Ana Karen Guzman Aguayo, Paloma Palma Guzmán, Reinhold Kreutz, Adrián Plaza de la Fuente, María S. Fernández‐Alfonso   +6 more
openalex   +1 more source

Inhibition of acetyl-CoA carboxylase

, 1982
openaire   +1 more source

Some of the next articles are maybe not open access.

Related searches:

Acetyl‐CoA Carboxylase Inhibitor GS‐0976 for 12 Weeks Reduces Hepatic De Novo Lipogenesis and Steatosis in Patients With Nonalcoholic Steatohepatitis

Clinical Gastroenterology and Hepatology, 2018
BACKGROUND & AIMS: Increased de novo lipogenesis (DNL) contributes to the pathogenesis of nonalcoholic steatohepatitis (NASH). Acetyl‐CoA carboxylase catalyzes the rate‐limiting step in DNL.
E. Lawitz, A. Coste, F. Poordad, N. Alkhouri, N. Loo, B. McColgan, J. Tarrant, Tuan Nguyen, Ling Han, C. Chung, A. Ray, J. Mchutchison, M. Subramanian, R. Myers, M. Middleton, C. Sirlin, R. Loomba, Edna Nyangau, M. Fitch, Kelvin W. Li, M. Hellerstein   +20 more
semanticscholar   +3 more sources

Regulation of acetyl-CoA carboxylase.

Biochemical Society Transactions, 2006
Acetyl-CoA carboxylase (ACC) catalyses the formation of malonyl-CoA, an essential substrate for fatty acid synthesis in lipogenic tissues and a key regulatory molecule in muscle, brain and other tissues. ACC contributes importantly to the overall control of energy metabolism and has provided an important model to explore mechanisms of enzyme control ...
R. Brownsey, A. Boone, J. E. Elliott, J. Kulpa, W. M. Lee   +4 more
semanticscholar   +3 more sources

Acetyl-CoA carboxylase (ACC) as a therapeutic target for metabolic syndrome and recent developments in ACC1/2 inhibitors

Expert Opinion on Investigational Drugs, 2019
Introduction: Acetyl-CoA Carboxylase (ACC) is an essential rate-limiting enzyme in fatty acid metabolism. For many years, ACC inhibitors have gained great attention for developing therapeutics for various human diseases including microbial infections ...
Leyuan Chen, Yuqing Duan, Huiqiang Wei, Hongxin Ning, Changfen Bi, Yingran Zhao, Yong Qin, Yiliang Li   +7 more
semanticscholar   +3 more sources

Regulation of mammalian acetyl-CoA carboxylase.

Biochemical Society Transactions, 2002
Acetyl-CoA carboxylase (ACC) plays a critical role in the regulation of fatty acid metabolism and its two isoforms, ACCα and ACCβ, appear to have distinct functions in the control of fatty acid synthesis and fatty acid oxidation, respectively. They are regulated by similar short-term mechanisms of allosteric activation by citrate, and reversible ...
M. Munday
semanticscholar   +3 more sources

Structural basis for regulation of human acetyl-CoA carboxylase

Nature, 2018
M. Hunkeler, A. Hagmann, E. Stuttfeld, M. Chami, Y. Guri, H. Stahlberg, T. Maier   +6 more
semanticscholar   +3 more sources

Regulation and structure of the heteromeric acetyl-CoA carboxylase.

Biochimica Et Biophysica Acta - Molecular and Cell Biology of Lipids, 2016
Matthew J Salie, J. Thelen
semanticscholar   +3 more sources

Wheat acetyl-CoA carboxylase

Plant Molecular Biology, 1993
The acetyl-CoA carboxylase present in both wheat germ and total wheat leaf protein contains ca. 220 kDa subunits. It is the major biotin-dependent carboxylase present in wheat chloroplasts. Active acetyl-CoA carboxylase purified from wheat germ is a homodimer with an apparent molecular mass of ca. 500 kDa.
P, Gornicki, R, Haselkorn
openaire   +2 more sources