Results 141 to 150 of about 396 (171)
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Acetyl-L-Carnitine in Diabetic Polyneuropathy
CNS Drugs, 2007Diabetic polyneuropathy (DPN) is the most common late complication of diabetes mellitus. The underlying pathogenesis is multifaceted, with partly interrelated mechanisms that display a dynamic course. The mechanisms underlying DPN in type 1 and type 2 diabetes mellitus show overlaps or may differ. The differences are mainly due to insulin deficiency in
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Acetyl-L-carnitine for patients with hepatic encephalopathy
Cochrane Database of Systematic Reviews, 2014Background Hepatic encephalopathy is a common and devastating neuropsychiatric complication of acute liver failure or chronic liver disease. Ammonia content in the blood seems to play a role in the development of hepatic encephalopathy. Treatment for hepatic encephalopathy is complex. Acetyl-L-carnitine is a substance that may reduce ammonia toxicity.
Arturo J MartÃ-Carvajal +2 more
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Alternative medicine review : a journal of clinical therapeutic, 2000
Acetyl-L-carnitine (ALC) is an ester of the trimethylated amino acid, L-carnitine, and is synthesized in the human brain, liver, and kidney by the enzyme ALC-transferase. Acetyl-L-carnitine facilitates the uptake of acetyl CoA into the mitochondria during fatty acid oxidation, enhances acetylcholine production, and stimulates protein and membrane ...
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Acetyl-L-carnitine (ALC) is an ester of the trimethylated amino acid, L-carnitine, and is synthesized in the human brain, liver, and kidney by the enzyme ALC-transferase. Acetyl-L-carnitine facilitates the uptake of acetyl CoA into the mitochondria during fatty acid oxidation, enhances acetylcholine production, and stimulates protein and membrane ...
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Trophic action of acetyl-L-carnitine in neuronal cultures.
Acta neurologica, 1992Daily addition of acetyl-L-carnitine (100 microM) to cultured cerebellar granule cells since the first day of maturation led to an increased rate of expression of D-[3H]aspartate uptake (an established marker of maturation of glutamatergic neurons) and of N-methyl-D-aspartate (NMDA) receptors linked to large conductance ion channels permeable to Ca2 ...
RAMPELLO, Liborio +4 more
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AIDS, 2004
Nucleoside analogue reverse transcriptase inhibitors (NRTI) disrupt neuronal mitochondrial DNA synthesis, impairing energy metabolism and resulting in a distal symmetrical polyneuropathy (DSP), an antiretroviral toxic neuropathy (ATN) that causes significant morbidity in HIV disease.
Hart, Andrew M. +6 more
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Nucleoside analogue reverse transcriptase inhibitors (NRTI) disrupt neuronal mitochondrial DNA synthesis, impairing energy metabolism and resulting in a distal symmetrical polyneuropathy (DSP), an antiretroviral toxic neuropathy (ATN) that causes significant morbidity in HIV disease.
Hart, Andrew M. +6 more
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Acetyl-L-Carnitine in Mood, Aging, and Disease
2002Acetyl-L-carnitine (ALCAR) is an acetyl derivative of carnitine, an endogenous molecule biosynthesized in vivo and supplemented by diet mainly from meat and dairy products. Both carnitine and acetyl moieties have important neurobiological properties. The acetyl moiety of ALCAR can be used to maintain acetyl-CoA levels and carnitine is important in the ...
Jay W. Pettegrew +2 more
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Preparation of radioactive acetyl-l-carnitine by an enzymatic exchange reaction
Analytical Biochemistry, 1982A rapid method for the preparation of (1-/sup 14/C)acetyl-L-carnitine is described. The method involves exchange of (1-/sup 14/C)acetic acid into a pool of unlabeled acetyl-L-carnitine using the enzymes acetyl-CoA synthetase and carnitine acetyltransferase.
R, Emaus, L L, Bieber
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Use of Acetyl-L-Carnitine in Gerontological Practice
Neuroscience and Behavioral Physiology, 2019Published data on the efficacy and safety of using acetyl-L-carnitine (ALC) in gerontological practice are analyzed and the spectrum of biochemical activity and mechanism of action are discussed. The profile and specificity of the actions of ALC are assessed, as is the potential for combining ALC with other drugs.
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Acetyl-L-carnitine ineffective in treatment of CIPN
The Lancet Oncology, 2013Previous studies had indicated that Acetyl-L-carnitine (ALC), a natural agent that enhances neuronal protection, might be a useful treatment option for patients with chemotherapy-induced peripheral neuropathy (CIPN). But, results from a recent phase 2 double-blind clinical trial have shown that ALC is not only an ineff ective treatment for CIPN, but it
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