Results 1 to 10 of about 4,697 (135)

Role of carnitine acetylation in skeletal muscle

Journal of Physical Fitness and Sports Medicine, 2014
Carnitine is known for its role in the transport of long-chain fatty acids into the mitochondrial matrix for subsequent β-oxidation. In addition, carnitine acts as an acceptor of excess acetyl-CoA and forms acetylcarnitine to relieve inhibition of ...
Yasuro Furuichi, Naoko Goto-Inoue, Nobuharu L. Fujii   +2 more
doaj   +1 more source

Stable isotope-labeled carnitine reveals its rapid transport into muscle cells and acetylation during contraction

Heliyon, 2023
Carnitine plays multiple roles in skeletal muscle metabolism, including fatty acid transport and buffering of excess acetyl-CoA in the mitochondria. The skeletal muscle cannot synthesize carnitine; therefore, carnitine must be taken up from the blood ...
Yasuro Furuichi, Naoko Goto-Inoue, Saki Uchida, Shun Masuda, Yasuko Manabe, Nobuharu L. Fujii   +5 more
doaj   +1 more source

An improved and simplified radioisotopic assay for the determination of free and esterified carnitine

Journal of Lipid Research, 1976
The radioisotopic assay for carnitine first described by Cederblad and Lindstedt (Clin. Chim. Acta. 37:235–543, 1972) and modified by Bøhmer et al (Clin. Chim. Acta. 57:55–61, 1974) has been improved and simplified. As a result, the assay yields a linear
J D McGarry, D W Foster
doaj   +1 more source

Application of Metabolomics to Identify Potential Biomarkers for the Early Diagnosis of Coronary Heart Disease

Frontiers in Physiology, 2021
Coronary heart disease (CHD) is one of the leading causes of deaths globally. Identification of serum metabolic biomarkers for its early diagnosis is thus much desirable.
Huali Jiang, Huali Jiang, Li Li, Weijie Chen, Benfa Chen, Heng Li, Shanhua Wang, Min Wang, Yi Luo, Yi Luo   +9 more
doaj   +1 more source

Impact of L-carnitine in narcolepsy treatment: a systematic review on the effectiveness and safety [PDF]

Sleep Science
Introduction: Studies have shown that narcolepsy patients may present with low serum acylcarnitine levels, demonstrating a dysfunctional beta fatty acid oxidation pathway in these patients.
Cristina Salles, Maria Clara Freitas, Miguel Meira e Cruz   +2 more
doaj   +1 more source

Levocarnitine for the Treatment of Polymorbid Patients

Рациональная фармакотерапия в кардиологии, 2020
Effective and safe treatment of patients with polymorbidity is an urgent task of modern healthcare. Of particular difficulty is the treatment of patients with cardiovascular comorbidity, which requires an integrated approach to the treatment and ...
A. P. Pereverzev, D. A. Shevchenko, A. V. Filippova, A. A. Kirichenko, I. F. Krotkova, O. D. Ostroumova   +5 more
doaj   +1 more source

Database screening as a strategy to identify endogenous candidate metabolites to probe and assess mitochondrial drug toxicity

Scientific Reports, 2023
Adverse drug reactions (ADRs) are considered an inherent risk of medication use, and some ADRs have been associated with off-target drug interactions with mitochondria. Metabolites that reflect mitochondrial function may help identify patients at risk of
Mery Vet George De la Rosa, Dipali Patel, Marc R. McCann, Kathleen A. Stringer, Gus R. Rosania   +4 more
doaj   +1 more source

Potential Diagnostic Biomarker Detection for Prostate Cancer Using Untargeted and Targeted Metabolomic Profiling

Current Issues in Molecular Biology, 2023
Prostate cancer (PCa) remains one of the leading causes of cancer mortality in men worldwide, currently lacking specific, early detection and staging biomarkers.
Diana Nitusca, Carmen Socaciu, Andreea Iulia Socaciu, Ioan Ovidiu Sirbu, Razvan Bardan, Alin Adrian Cumpanas, Edward Seclaman, Catalin Marian   +7 more
doaj   +1 more source

Inadvertent intrathecal drug injection while treating low back pain: a case report and review of the literature

Journal of Medical Case Reports, 2023
Background Undesired intrathecal injections represent an important subset of medical errors, albeit rare. Clinical effects depend on the type and concentration of drug(s) injected.
Alessandro Ferrieri, Donatella Bosco, Ennio Polilli, Raffaella Ciulli, Lina Visocchi, Lucrezia Mincione, Rosa Iacoe, Rosamaria Zocaro, Antonella Frattari   +8 more
doaj   +1 more source

Transplacental exposure to AZT induces adverse neurochemical and behavioral effects in a mouse model: protection by L-acetylcarnitine. [PDF]

PLoS ONE, 2013
Maternal-fetal HIV-1 transmission can be prevented by administration of AZT, alone or in combination with other antiretroviral drugs to pregnant HIV-1-infected women and their newborns. In spite of the benefits deriving from this life-saving prophylactic
Anna Rita Zuena, Chiara Giuli, Aldina Venerosi Pesciolini, Antonella Tramutola, Maria Antonietta Ajmone-Cat, Carlo Cinque, Giovanni Sebastiano Alemà, Angela Giovine, Gianfranco Peluso, Luisa Minghetti, Raffaella Nicolai, Gemma Calamandrei, Paola Casolini   +12 more
doaj   +1 more source