Results 11 to 20 of about 4,697 (135)

Analgesia induced by the epigenetic drug, L-acetylcarnitine, outlasts the end of treatment in mouse models of chronic inflammatory and neuropathic pain

Molecular Pain, 2017
Background L-acetylcarnitine, a drug marketed for the treatment of chronic pain, causes analgesia by epigenetically up-regulating type-2 metabotropic glutamate (mGlu2) receptors in the spinal cord.
Milena Cannella, Giada Mascio, Giuseppe Battaglia   +2 more
exaly   +2 more sources

Skeletal muscle energetics during submaximal contractions are linked to metabolic performance during ambulatory exercise: A pilot study in male adults [PDF]

Physiological Reports
Skeletal muscle's capacity for oxidative energy production can be measured in vivo by phosphocreatine (PCr) recovery following maximal contractions inside a magnetic resonance scanner.
Christopher M. T. Hayden, Michael A. Busa, Zoe H. Smith, Rajakumar Nagarajan, Luke R. Arieta, Jane A. Kent   +5 more
doaj   +2 more sources

Elucidating the causal links between plasma and cerebrospinal fluid metabolites and pituitary tumors: a Mendelian randomization analysis [PDF]

Frontiers in Endocrinology
BackgroundPituitary tumors (PTs) are common benign intracranial tumors. Investigating the metabolites in serum and cerebrospinal fluid in PTs is essential to understanding the underlying biological mechanisms and identifying new biomarkers and ...
Wencai Wang, Menghao Liu, Zun Wang, Wei Ye, Xianfeng Li   +4 more
doaj   +2 more sources

Epimedii Folium Supplementation Improves Semen Quality, Hormonal Profile, and Immune Function by Modulating Gut Microbiota and Seminal Metabolites in Aged Boars [PDF]

Animals
This study aimed to investigate the effects of dietary Herba Epimedii Folium (HEF) supplementation on semen quality, reproductive hormones, immune parameters, gut microbiota, and seminal plasma metabolites in aged boars, and to evaluate its potential for
Bin Ran, Shengxin Luo, Chenxi Zhou, Long Wen, Junjie Wu, Yunxiang Zhao, Xiaoping Zhu, Zhili Li, Mengjie Liu   +8 more
doaj   +2 more sources

Discovery and validation of acetyl-L-carnitine in serum for diagnosis of major depressive disorder and remission status through metabolomic approach

Frontiers in Psychiatry, 2022
Major depressive disorder (MDD) is one of the most common psychiatric disorders that accompany psychophysiological and mood changes. However, the pathophysiology-based disease mechanism of MDD is not yet fully understood, and diagnosis is also conducted ...
Seungyeon Lee, Sora Mun, You-Rim Lee, Hyebin Choi, Eun-Jeong Joo, Eun-Jeong Joo, Hee-Gyoo Kang, Hee-Gyoo Kang, Jiyeong Lee   +8 more
doaj   +1 more source

Clofazimine-Mediated, Age-Related Changes in Skeletal Muscle Mitochondrial Metabolites

Metabolites, 2023
Mitochondrial health declines with age, and older patients can demonstrate dysfunction in mitochondrial-rich tissues, such as cardiac and skeletal muscle. Aged mitochondria may make older adults more susceptible to adverse drug reactions (ADRs).
Jennifer Diaz-Espinosa, Kathleen A. Stringer, Gus R. Rosania   +2 more
doaj   +1 more source

The Role of Acetyl-Carnitine and Rehabilitation in the Management of Patients with Post-COVID Syndrome: Case-Control Study

Applied Sciences, 2022
Post-COVID syndrome is characterized by the persistence of nonspecific disabling symptoms, even several months after the resolution of the infection, with clinical characteristics similar to fibromyalgia (FM) and a prevalence of 31%.
Dalila Scaturro, Fabio Vitagliani, Vito Emanuele Di Bella, Vincenzo Falco, Sofia Tomasello, Lorenza Lauricella, Giulia Letizia Mauro   +6 more
doaj   +1 more source

Multidimensional predictors of antidepressant responses: Integrating mitochondrial, genetic, metabolic and environmental factors with clinical outcomes

Neurobiology of Stress, 2021
Major depressive disorder (MDD) is a primary psychiatric illness worldwide; there is a dearth of new mechanistic models for the development of better therapeutic strategies.
Carla Nasca, Olivia Barnhill, Paolo DeAngelis, Kathleen Watson, Jue Lin, James Beasley, Sarah P. Young, Alison Myoraku, Josh Dobbin, Benedetta Bigio, Bruce McEwen, Natalie Rasgon   +11 more
doaj   +1 more source

A Multivariate Metabolomics Method for Estimating Platelet Mitochondrial Oxygen Consumption Rates in Patients with Sepsis

Metabolites, 2020
Background: Sepsis-induced alterations in mitochondrial function contribute to organ dysfunction and mortality. Measuring mitochondrial function in vital organs is neither feasible nor practical, highlighting the need for non-invasive approaches ...
Marc R. McCann, Cora E. McHugh, Maggie Kirby, Theodore S. Jennaro, Alan E. Jones, Kathleen A. Stringer, Michael A. Puskarich   +6 more
doaj   +1 more source

Perinatal free carnitine and short chain acylcarnitine blood concentrations in 12,000 full-term breastfed newborns in relation to their birth weight

Pediatrics and Neonatology, 2020
Background: Free carnitine (C0) and short chain acylcarnitine (SCA) blood concentrations play a significant role in fatty acid oxidation process during the first days of life.
Penelope D. Manta-Vogli, Kleopatra H. Schulpis, Yannis L. Loukas, Yannis Dotsikas   +3 more
doaj   +1 more source