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Acylcarnitine profile analysis [PDF]

Genetics in Medicine, 2008
These Technical Standards and Guidelines were developed primarily as an educational resource for clinical laboratory geneticists to help them provide quality clinical laboratory genetic services. Adherence to these standards and guidelines is voluntary and does not necessarily assure a successful medical outcome.
Piero, Rinaldo, Tina M, Cowan, Dietrich, Matern   +2 more
openaire   +2 more sources

The NADPH oxidase NOX4 regulates redox and metabolic homeostasis preventing HCC progression

Hepatology, EarlyView., 2022
Loss of NOX4 in HCC tumor cells induces metabolic reprogramming in a Nrf2/MYC‐dependent manner to promote HCC progression. Abstract Background and Aims The NADPH oxidase NOX4 plays a tumor‐suppressor function in HCC. Silencing NOX4 confers higher proliferative and migratory capacity to HCC cells and increases their in vivo tumorigenic potential in ...
Irene Peñuelas‐Haro, Rut Espinosa‐Sotelo, Eva Crosas‐Molist, Macarena Herranz‐Itúrbide, Daniel Caballero‐Díaz, Ania Alay, Xavier Solé, Emilio Ramos, Teresa Serrano, María L. Martínez‐Chantar, Ulla G. Knaus, José M. Cuezva, Antonio Zorzano, Esther Bertran, Isabel Fabregat   +14 more
wiley   +1 more source

A Marked Low-Grade Inflammation and a Significant Deterioration in Metabolic Status in First-Episode Schizophrenia: A Five-Year Follow-Up Study

Metabolites, 2022
The objective of this study was to evaluate how schizophrenia spectrum disorders and applied long-term (5.1 years) antipsychotic (AP) treatment affect the serum level of acylcarnitines (ACs), cytokines and metabolic biomarkers and to characterize the ...
Madis Parksepp, Liina Haring, Kalle Kilk, Egon Taalberg, Raul Kangro, Mihkel Zilmer, Eero Vasar   +6 more
doaj   +1 more source

Plasma acylcarnitine concentrations reflect the acylcarnitine profile in cardiac tissues [PDF]

Scientific Reports, 2017
AbstractIncreased plasma concentrations of acylcarnitines (ACs) are suggested as a marker of metabolism disorders. The aim of the present study was to clarify which tissues are responsible for changes in the AC pool in plasma. The concentrations of medium- and long-chain ACs were changing during the fed-fast cycle in rat heart, muscles and liver. After
Makrecka-Kuka, Marina, Sevostjanovs, Eduards, Vilks, Karlis, Volska, Kristine, Antone, Unigunde, Kuka, Janis, Makarova, Elina, Pugovics, Osvalds, Dambrova, Maija, Liepinsh, Edgars   +9 more
openaire   +2 more sources

Long-Chain Acylcarnitines and Monounsaturated Fatty Acids Discriminate Heart Failure Patients According to Pulmonary Hypertension Status

Metabolites, 2021
Defects in fatty acid (FA) utilization have been well described in group 1 pulmonary hypertension (PH) and in heart failure (HF), yet poorly studied in group 2 PH.
Maxime Tremblay-Gravel, Annik Fortier, Cantin Baron, Chloé David, Pamela Mehanna, Anique Ducharme, Julie Hussin, Qinghua Hu, Jean-Claude Tardif, Christine Des Rosiers, Jocelyn Dupuis, Matthieu Ruiz   +11 more
doaj   +1 more source

Ischemic Stroke Causes Disruptions in the Carnitine Shuttle System

Metabolites, 2023
Gaining a deep understanding of the molecular mechanisms underlying ischemic stroke is necessary to develop treatment alternatives. Ischemic stroke is known to cause a cellular energy imbalance when glucose supply is deprived, enhancing the role for ...
Leonidas Mavroudakis, Ingela Lanekoff
doaj   +1 more source

The metabolomics approach revealed a distinctive metabolomics pattern associated with hyperthyroidism treatment

Frontiers in Endocrinology, 2022
BackgroundHyperthyroidism is characterized by increased thyroid hormone production, which impacts various processes, including metabolism and energy expenditure.
Malak A. Jaber, Hicham Benabdelkamel, Lina A. Dahabiyeh, Afshan Masood, Reem H. AlMalki, Reem H. AlMalki, Mohthash Musambil, Assim A. Alfadda, Assim A. Alfadda, Anas M. Abdel Rahman, Anas M. Abdel Rahman, Anas M. Abdel Rahman   +11 more
doaj   +1 more source

Metabolic features of adiposity and glucose homoeostasis among school-aged inuit children from Nunavik (Northern Quebec, Canada)

International Journal of Circumpolar Health, 2021
In contrast to most Indigenous people in Canada, Inuit appeared until recently to have been protected from type 2 diabetes (T2D) related to obesity. We assessed the associations of metabolites (amino acids, acylcarnitines) with adiposity and biomarkers ...
Thierry Comlan Marc Medehouenou, Cynthia Roy, Pierre-Yves Tremblay, Audray St-Jean, Salma Meziou, Gina Muckle, Pierre Ayotte, Michel Lucas   +7 more
doaj   +1 more source

A Preliminary Metabolomic Study of Yorkshire Terrier Enteropathy

Metabolites, 2022
Perturbations of metabolite profiles in human and canine enteropathies have been reported before. However, data in dogs are scarce and inconsistent. Currently, the metabolite profile in Yorkshire Terrier enteropathy (YTE) and the impact of treatment is ...
Alexandra I. Galler, Kristaps Klavins, Iwan A. Burgener   +2 more
doaj   +1 more source

Plasma acylcarnitines could predict prognosis and evaluate treatment of IgA nephropathy

Nutrition & Metabolism, 2019
Background Effective evaluation or prediction of therapy response could be helpful for treatment of chronic kidney disease (CKD), which may rely on accurate biomarkers. Acylcarnitines are involved with lipid metabolism and mitochondrial function.
Fang-Ying Xia, Li Zhu, Chao Xu, Qing-Qing Wu, Wan-Jia Chen, Rong Zeng, Yue-Yi Deng   +6 more
doaj   +1 more source