Results 11 to 20 of about 10,947 (199)

Paediatric CSF acylcarnitine reference ranges [PDF]

Frontiers in Molecular Biosciences
Acylcarnitines play a crucial role in energy metabolism pathways, primarily known for their involvement in the beta oxidation of fatty acids. However, their roles extend beyond mitochondrial transport; they also contribute to the synthesis of lipids in ...
Ontefetse Neo Plaatjie, A. Marceline Tutu Van Furth, A. Marceline Tutu Van Furth, Regan Solomons, Martijn Van Der Kuip, Shayne Mason   +5 more
doaj   +6 more sources

SGLT2 inhibition, acylcarnitines and heart failure: a Mendelian randomization study [PDF]

Open Heart
Objective Sodium-glucose cotransporter 2 (SGLT2) inhibitors are guideline-recommended agents for treating heart failure (HF), but the role of metabolomic biomarkers in underlying mechanisms, particularly acylcarnitines, remains unclear.
Liming Li, Zhengming Chen, Junshi Chen, Ling Yang, Dianjianyi Sun, Hong Guo, Jun Lv, Yiping Chen, Dan Schmidt, Xiaoming Yang, Pei Pei, Canqing Yu, Yuanjie Pang, Iona Y Millwood, Robin G Walters, Zhiyu Wu, Shuyao Song   +16 more
doaj   +2 more sources

Serum Acylcarnitines and Risk of Cardiovascular Death and Acute Myocardial Infarction in Patients With Stable Angina Pectoris

Journal of the American Heart Association, 2017
BackgroundExcess levels of serum acylcarnitines, which are intermediate products in metabolism, have been observed in metabolic diseases such as type 2 diabetes mellitus.
Gunnar Mellgren, Bodil Bjørndal, Ottar Nygård   +2 more
exaly   +3 more sources

The Effect of Acylcarnitines on Cognitive Function: A Two‐Sample Mendelian Randomization Study

Brain and Behavior
Objective Clinical trials investigating the association between acylcarnitines and cognitive function have yielded conflicting results. We conducted a Mendelian randomization (MR) study to examine the causal associations between 20 acylcarnitines and ...
Sisi Luan
exaly   +2 more sources

Fully Automated Serum LC-MS/MS Platform and Pediatric Reference Intervals for Organic Acids, Amino Acids, and Acylcarnitines in Children (Ages 0–6 Years): Toward Quantitative Diagnosis of Inborn Errors of Metabolism [PDF]

Diagnostics
Background/Objectives: Conventional diagnosis of inborn errors of metabolism (IEMs) requires multiple specimen types—urine organic acids, plasma amino acids, and serum acylcarnitines—analyzed on distinct analytical platforms. This multi-assay approach is
Yasushi Ueyanagi, Daiki Setoyama, Tsuyoshi Nakanishi, Yuichi Mushimoto, Vlad Tocan, Hironori Kobayashi, Miki Matsui, Shinya Matsumoto, Akiyoshi Fujishima, Taeko Hotta, Ayumi Sakata, Yuya Kunisaki   +11 more
doaj   +2 more sources

Correlation of Serum Acylcarnitines with Clinical Presentation and Severity of Coronary Artery Disease

Biomolecules, 2022
Recent studies support that acylcarnitines exert a significant role in cardiovascular disease development and progression. The aim of this metabolomics-based study was to investigate the association of serum acylcarnitine levels with coronary artery ...
Efstratios Karagiannidis, Helen Gika, Georgios Theodoridis   +2 more
exaly   +3 more sources

The association between acylcarnitine and amino acids profile and metabolic syndrome and its components in Iranian adults: Data from STEPs 2016

Frontiers in Endocrinology, 2023
BackgroundEvidence, albeit with conflicting results, has suggested that cardiometabolic risk factors, including obesity, type 2 diabetes (T2D), dyslipidemia, and hypertension, are highly associated with changes in metabolic signature, especially plasma ...
Hananeh Taghizadeh, Solaleh Emamgholipour, Shaghayegh Hosseinkhani, Babak Arjmand, Negar Rezaei, Arezou Dilmaghani-Marand, Erfan Ghasemi, Nekoo Panahi, Hojat Dehghanbanadaki, Robabeh Ghodssi-Ghassemabadi, Niloufar Najjar, Mojgan Asadi, Mohsen khoshniat, Bagher Larijani, Farideh Razi   +14 more
doaj   +1 more source

Metabolic Pathways of Acylcarnitine Synthesis

Physiological Research, 2023
Acylcarnitines are important markers in metabolic studies of many diseases, including metabolic, cardiovascular, and neurological disorders. We reviewed analytical methods for analyzing acylcarnitines with respect to the available molecular structural information, the technical limitations of legacy methods, and the potential of new mass spectrometry ...
Jana Brejchova, Kristyna Brejchova, Ondrej Kuda   +2 more
openaire   +3 more sources

Increasing maternal age associates with lower placental CPT1B mRNA expression and acylcarnitines, particularly in overweight women

Frontiers in Physiology, 2023
Older pregnant women have increased risks of complications including gestational diabetes and stillbirth. Carnitine palmitoyl transferase (CPT) expression declines with age in several tissues and is linked with poorer metabolic health. Mitochondrial CPTs
Hannah E. J. Yong, Oliver C. Watkins, Tania K. L. Mah, Victoria K. B. Cracknell-Hazra, Victoria K. B. Cracknell-Hazra, Reshma Appukuttan Pillai, Preben Selvam, Mohammad O. Islam, Neha Sharma, Amaury Cazenave-Gassiot, Amaury Cazenave-Gassiot, Anne K. Bendt, Markus R. Wenk, Markus R. Wenk, Keith M. Godfrey, Keith M. Godfrey, Rohan M. Lewis, Rohan M. Lewis, Shiao-Yng Chan, Shiao-Yng Chan   +19 more
doaj   +1 more source

Tissue Specific Distribution and Activation of Sapindaceae Toxins in Horses Suffering from Atypical Myopathy

Animals, 2023
Equine atypical myopathy is caused by hypoglycin A (HGA) and methylenecyclopropylglycine (MCPrG), the known protoxins of sycamore maple (Acer pseudoplatanus). Various tissues from five atypical myopathy cases were analyzed but only HGA was found. Whether
Johannes Sander, Michael Terhardt, Nils Janzen, Benoît Renaud, Caroline-Julia Kruse, Anne-Christine François, Clovis P. Wouters, François Boemer, Dominique-Marie Votion   +8 more
doaj   +1 more source