Results 21 to 30 of about 4,697 (135)

Acetylcarnitine Is Associated With Cardiovascular Disease Risk in Type 2 Diabetes Mellitus

Frontiers in Endocrinology, 2021
ObjectiveThis study aimed to identify the association between specific short-chain acylcarnitines and cardiovascular disease (CVD) in type 2 diabetes mellitus (T2DM).MethodWe retrieved 1,032 consecutive patients with T2DM who meet the inclusion and ...
Shuo Zhao, Shuo Zhao, Ming-Li Liu, Bing Huang, Fu-Rong Zhao, Ying Li, Xue-Ting Cui, Rong Lin   +7 more
doaj   +1 more source

Chemoreactomic analysis of citrulline malate molecules

Неврология, нейропсихиатрия, психосоматика, 2017
Citrulline malate that is essential for the biosynthesis of arginine promotes dehydration of ammonium endotoxins, by participating in the urea cycle. The indications for the use of citrulline malate are functional asthenia, asthenic syndrome, overfatigue,
I. Yu. Torshin, O. A. Gromova, L. E. Fedotova, A. N. Gromov, K. V. Rudakov   +4 more
doaj   +1 more source

Dynamic Changes in Plasma Metabolic Profiles Reveal a Potential Metabolite Panel for Interpretation of Fatal Intoxication by Chlorpromazine or Olanzapine in Mice

Metabolites, 2022
Diagnosing the cause of fatal intoxication by antipsychotic agents is an important task in forensic practice. In the 2020 Annual Report of the American Association of Poison Control Centers, among 40 deaths caused by antipsychotics, 21 cases were ...
Rui Bai, Xiaohui Dai, Xingang Miao, Bing Xie, Feng Yu, Bin Cong, Di Wen, Chunling Ma   +7 more
doaj   +1 more source

Antioxidant effect of acetyl--carnitine against cisplatin-induced cardiotoxicity

Journal of International Medical Research, 2020
Objective Cisplatin (CDDP) toxicity is a dose-limiting clinical problem in clinical practice, mainly because of nephrotoxicity or ototoxicity. However, the mechanism of CDDP-induced cardiotoxicity is poorly understood.
Serdar Bayrak, Safiye Aktaş, Zekiye Altun, Yasemin Çakir, Merve Tütüncü, Selen Kum Özşengezer, Osman Yilmaz, Nur Olgun   +7 more
doaj   +1 more source

Metabolomic analysis reveals spermatozoa and seminal plasma differences between Duroc and Liang guang Small-spotted pig

Frontiers in Veterinary Science, 2023
The Liang guang Small-spotted pig is a well-known Chinese indigenous pig that is valued for its exceptional meat quality. However, the Liang guang Small-spotted pig has a lower semen storage capacity, shorter storage time and worse semen quality compared
Zhili Li, Jingshuai Sun, Kebiao Li, Jiali Qin, Yanmei Sun, Jianhua Zeng, Saeed El-Ashram, Yunxiang Zhao, Yunxiang Zhao   +8 more
doaj   +1 more source

Carnitine supplementation improves metabolic flexibility and skeletal muscle acetylcarnitine formation in volunteers with impaired glucose tolerance: A randomised controlled trial

EBioMedicine, 2019
Background: Type 2 diabetes patients and individuals at risk of developing diabetes are characterized by metabolic inflexibility and disturbed glucose homeostasis.
Yvonne MH Bruls, Marlies de Ligt, Lucas Lindeboom, Esther Phielix, Bas Havekes, Gert Schaart, Esther Kornips, Joachim E Wildberger, Matthijs KC Hesselink, Deborah Muoio, Patrick Schrauwen, Vera B Schrauwen-Hinderling   +11 more
doaj   +1 more source

Synergic action of L-acetylcarnitine and L-methylfolate in Mouse Models of Stress-Related Disorders and Human iPSC-Derived Dopaminergic Neurons

Frontiers in Pharmacology, 2022
The epigenetic agents, L-acetylcarnitine (LAC) and L-methylfolate (MF) are putative candidates as add-on drugs in depression. We evaluated the effect of a combined treatment with LAC and MF in two different paradigms of chronic stress in mice and in ...
Rosamaria Orlando, Rosamaria Orlando, Roxana Paula Ginerete, Laura Cavalleri, Vincenza Aliperti, Tiziana Imbriglio, Giuseppe Battaglia, Giuseppe Battaglia, Anna Rita Zuena, Ferdinando Nicoletti, Ferdinando Nicoletti, Emilio Merlo Pich, Ginetta Collo   +12 more
doaj   +1 more source

Azithromycin in Chronic Fatigue Syndrome (CFS), an analysis of clinical data

Journal of Translational Medicine, 2006
Background CFS is a clinical state with defined symptoms, but undefined cause. The patients may show a chronic state of immune activation and treatment with an antibiotic in this subgroup has been suggested. Methods In a retrospective study, the response
Scholte Hans R, Vermeulen Ruud CW
doaj   +1 more source

Milk Metabolomics Reveals Potential Biomarkers for Early Prediction of Pregnancy in Buffaloes Having Undergone Artificial Insemination

Animals, 2020
This study aimed to identify potential biomarkers for early pregnancy diagnosis in buffaloes subjected to artificial insemination (AI). The study was carried out on 10 pregnant and 10 non-pregnant buffaloes that were synchronized by Ovsynch-Timed ...
Donato de Nicola, Francesco Vinale, Angela Salzano, Giada d’Errico, Anastasia Vassetti, Nunzia D’Onofrio, Maria Luisa Balestrieri, Gianluca Neglia   +7 more
doaj   +1 more source

Identification of Novel Serum Metabolic Biomarkers as Indicators in the Progression of Intravenous Leiomyomatosis: A High Performance Liquid Chromatography-Tandem Mass Spectrometry-Based Study

Frontiers in Cell and Developmental Biology, 2021
BackgroundIntravenous leiomyomatosis (IVL) is a rare estrogen-dependent neoplasm. However, identifiable and reliable biomarkers are still not available for clinical application, especially for the diagnosis and prognosis of the disease.MethodsIn the ...
Zhitong Ge, Penghui Feng, Zijuan Zhang, Jianchu Li, Qi Yu   +4 more
doaj   +1 more source